H(+)-K(+)-Exchanging ATPase (Hydrogen, Potassium ATPase)

An enzyme isolated from the GASTRIC MUCOSA that catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions across the cell wall. This enzyme was formerly listed as EC 3.6.1.36.

Also Known As:

Hydrogen, Potassium ATPase; Potassium Hydrogen ATPase; Adenosine Triphosphatase, Hydrogen, Potassium; Gastric H(+) K(+) ATPase; Hydrogen, Potassium, Adenosine Triphosphatase; Hydrogen-Potassium-Exchanging ATPase; ATPase Hydrogen, Potassium; ATPase, Hydrogen-Potassium-Exchanging; ATPase, Potassium Hydrogen; Hydrogen Potassium Exchanging ATPase; ATPase, Hydrogen, Potassium; Adenosinetriphosphatase, Hydrogen, Potassium; H(+)-K(+)-Transporting ATPase; Hydrogen, Potassium, Adenosinetriphosphatase; ATP phosphohydrolase (H+/K+-transporting)

Networked: 77 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gleeson, Paul A: 8 articles (07/2014 - 09/2002)
2.	van Driel, Ian R: 6 articles (07/2014 - 10/2002)
3.	Toh, B H: 5 articles (12/2001 - 01/2000)
4.	Toh, Ban-Hock: 4 articles (01/2017 - 02/2004)
5.	Read, Simon: 4 articles (06/2014 - 02/2006)
6.	Zwar, Tricia D: 4 articles (08/2007 - 09/2002)
7.	Alderuccio, F: 4 articles (02/2001 - 01/2000)
8.	Hogan, Thea V: 3 articles (07/2014 - 08/2007)
9.	Alderuccio, Frank: 3 articles (06/2012 - 02/2004)
10.	Judd, Louise M: 3 articles (08/2005 - 10/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2005 - "To study this, mice lacking the gastric H/K-ATPase (Atp4a(-/-) mice) were used to determine whether chronic loss of acid secretion, with attendant hypergastrinemia, predisposes to cancer phenotype. " 12/15/2004 - "On the basis of the fact that blocking the clearance of acidic metabolites are known to induce the cell death, we hypothesized that pantoprazole (PPZ), one of gastric H+/K(+)-ATPase inhibitors used frequently to treat acid-related diseases, could inhibit growth of tumor cells. " 11/01/2018 - "Gastric H+/K+-ATPase or vacuolar-ATPases (V-ATPases) are critical for the cancer cells survival and growth in the ischemic microenvironment by extruding protons from the cell. " 10/01/2014 - "Intracellular proton extrusion in gastric cancer cells has been reported to promote cancer cell survival under acidic conditions via hydrogen/potassium adenosine triphosphatase (H+/K+-ATPase). "
2.	Zollinger-Ellison Syndrome (Syndrome, Zollinger-Ellison) 04/01/1992 - "Omeprazole is a new hydrogen-potassium adenosine triphosphatase antagonist with indications for severe reflux esophagitis and Zollinger-Ellison syndrome. " 05/01/1987 - "The initial concern for the development of gastric carcinoid lesions in rodents, maintained for long periods on high doses of omeprazole, defused the initial enthusiasm for this hydrogen-potassium ATPase "proton pump" inhibitor, but recent studies continue to show a marked efficacy of this agent for the short-term care of patients with gastric or duodenal ulcers and for the management of patients with the Zollinger-Ellison syndrome. "
3.	Carcinoid Tumor (Carcinoid) 07/01/2016 - "ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit." 05/01/1987 - "The initial concern for the development of gastric carcinoid lesions in rodents, maintained for long periods on high doses of omeprazole, defused the initial enthusiasm for this hydrogen-potassium ATPase "proton pump" inhibitor, but recent studies continue to show a marked efficacy of this agent for the short-term care of patients with gastric or duodenal ulcers and for the management of patients with the Zollinger-Ellison syndrome. "
4.	Duodenal Ulcer (Curling's Ulcer) 05/01/1987 - "The initial concern for the development of gastric carcinoid lesions in rodents, maintained for long periods on high doses of omeprazole, defused the initial enthusiasm for this hydrogen-potassium ATPase "proton pump" inhibitor, but recent studies continue to show a marked efficacy of this agent for the short-term care of patients with gastric or duodenal ulcers and for the management of patients with the Zollinger-Ellison syndrome. "
5.	Gastroesophageal Reflux (GERD) 05/01/2001 - "Blockade of the gastric acid pump, hydrogen-potassium adenosine triphosphatase (H+,K+-ATPase), by proton pump inhibitors (PPIs) is one of the most effective treatments for gastro-oesophageal reflux disease (GORD). " 12/01/2005 - "Current therapies to treat gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), and other acid-related diseases either prevent stimulation of the parietal cell (H2 receptor antagonists, H2RAs) or inhibit gastric H+,K+-ATPase (e.g., proton pump inhibitors, PPIs). "

Related Drugs and Biologics

1.	Proton Pump Inhibitors
2.	Acids
3.	Omeprazole (Prilosec)
4.	Adenosine Triphosphatases (ATPase)
5.	Pantoprazole (Protonix)
6.	Protons (Proton)
7.	Proton-Translocating ATPases (ATPase, H+)
8.	Ellagic Acid
9.	Adenosine Triphosphate (ATP)
10.	Autoantibodies

Related Therapies and Procedures

1.	Thymectomy
2.	Therapeutics