HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Hyperpigmentation

Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
Also Known As:
Hypermelanosis; Hypermelanoses
Networked: 1772 relevant articles (117 outcomes, 114 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Melanosis (Freckles)
2. Acne Vulgaris
3. Cicatrix (Scar)
4. Erythema
5. Addison Disease (Addison's Disease)

Experts

1. Hwang, Bang Yeon: 8 articles (07/2015 - 11/2009)
2. Kim, Youngsoo: 8 articles (07/2015 - 05/2002)
3. Gold, Michael H: 7 articles (12/2014 - 06/2006)
4. Goldman, Mitchel P: 7 articles (03/2013 - 01/2002)
5. Han, Sang-Bae: 6 articles (07/2015 - 11/2009)
6. Imokawa, Genji: 6 articles (06/2015 - 02/2002)
7. Harii, Kiyonori: 6 articles (05/2011 - 12/2002)
8. Yoshimura, Kotaro: 6 articles (05/2011 - 12/2002)
9. Moon, Hyung Ryong: 5 articles (12/2015 - 04/2011)
10. Passeron, Thierry: 5 articles (12/2015 - 04/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperpigmentation:
1. Tretinoin (Retinoic Acid)FDA LinkGeneric
2. hydroquinone (Black and White)FDA Link
3. Melanins (Melanin)IBA
4. tazarotene (Tazorac)FDA Link
01/01/2006 - "Once-daily application of tazarotene cream was shown to be effective against PIH, achieving significantly greater reductions compared with vehicle in overall disease severity and in the intensity and area of hyperpigmentation within 18 weeks (P< or =.05). "
11/01/2002 - "Compared with the vehicle, at week 24 tazarotene resulted in a significantly greater incidence of patients achieving treatment success (>or=50% global improvement) and at least a 1-grade improvement in fine wrinkling, mottled hyperpigmentation, lentigines, elastosis, pore size, irregular depigmentation, tactile roughness, coarse wrinkling, and the overall integrated assessment of photodamage (P<.01). "
12/01/2004 - "In this multicentre, double-blind, randomized, vehicle-controlled study, 50 patients with photodamaged facial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0.1% cream or vehicle cream to their face, once daily for 24 weeks. "
06/01/2004 - "All significant between-group differences in efficacy measures were in favor of tazarotene - for fine wrinkling at the study endpoint and, at earlier timepoints, for treatment success (> or =50% global improvement), and the overall integrated assessment of photodamage, mottled hyperpigmentation, and coarse wrinkling. "
02/01/2005 - "Tazarotene cream was significantly more effective than vehicle in reducing fine wrinkles, mottled hyperpigmentation, lentigines, irregular depigmentation, apparent pore size, elastosis, tactile roughness, and an overall integrated assessment of photodamage. "
5. Bleaching AgentsIBA
6. 1-phenyl-3,3-dimethyltriazene (PDT)IBA
7. Monophenol Monooxygenase (Tyrosinase)IBA
8. glycolic acid (glycolate)IBA
9. Vitamin EFDA LinkGeneric
10. Niacinamide (Nicotinamide)FDA LinkGeneric

Therapies and Procedures

1. Solid-State Lasers
2. Lasers (Laser)
3. Aftercare (After-Treatment)
4. Transplants (Transplant)
5. Laser Therapy (Surgery, Laser)