|1.||Coffman, Thomas M: 10 articles (01/2013 - 12/2003)|
|2.||Verbeuren, Tony J: 9 articles (05/2012 - 11/2005)|
|3.||Vanhoutte, Paul M: 7 articles (11/2014 - 02/2005)|
|4.||Cohen, Richard A: 6 articles (05/2012 - 01/2002)|
|5.||Dakshinamurti, S: 5 articles (02/2015 - 02/2006)|
|6.||Koller, Beverly H: 5 articles (01/2013 - 12/2003)|
|7.||Félétou, Michel: 5 articles (05/2010 - 01/2008)|
|8.||Narumiya, Shuh: 4 articles (07/2015 - 09/2004)|
|9.||Wilcox, Christopher S: 4 articles (05/2015 - 04/2002)|
|10.||Jiang, Bingbing: 4 articles (05/2012 - 11/2005)|
|1.||Myocardial Ischemia (Ischemic Heart Diseases)
11/01/1987 - "Since TxA2 induces platelet aggregation, coronary vasoconstriction and has a direct cytolytic effect, thromboxane receptor antagonists would be expected to be beneficial in acute myocardial ischemia. "
12/01/1985 - "Since TxA2 induces platelet aggregation, coronary vasoconstriction, and has a direct cytolytic effect, thromboxane receptor antagonism would be expected to be beneficial in acute myocardial ischemia. "
12/01/2008 - "These data indicate that endogenous TxA2 participates in myocardial ischemia-mediated sympathoexcitatory reflex responses through a TP receptor mechanism."
12/01/2008 - "We hypothesized that endogenous TxA2 contributes to sympathoexcitatory reflexes during myocardial ischemia through stimulation of TxA2/prostaglandin endoperoxide (TP) receptors. "
06/01/2005 - "MPA or DHT induction of CH in intact adult male primates, hypothesized to occur via androgenic up-regulation of vascular muscle TP receptor expression, could predispose to CH-mediated myocardial ischemia."
05/01/1999 - "Compounds which inhibit the synthesis of thromboxane synthase, block the thromboxane receptor or have the dual activity were effective in experimental thrombosis models in animals but not predictive of results in humans. "
09/01/1998 - "A new thromboxane receptor antagonist, Z-335, ameliorates experimental thrombosis without prolonging the rat tail bleeding time."
10/01/2012 - "Using a genetic approach, we investigated the role of thromboxane receptor (TP) pathway in CRP-induced thrombosis. "
12/15/2010 - "Although TXA₂ acts by binding to a seven-transmembrane receptor (i.e., the prostanoid TP receptor) that participates in the genesis of thrombosis, currently, there are no antagonists available for clinical use. "
01/01/2010 - "Thromboxane A(2) and the activation of TP receptors that it causes play an important role in platelet aggregation and therefore in thrombosis. "
|3.||Asthma (Bronchial Asthma)
09/01/1992 - "We conclude that thromboxane is not important in the maintenance of airway hyperresponsiveness in chronic asthma and that thromboxane receptor antagonists are unlikely to provide effective treatment for this group of patients."
02/01/1996 - "In this review, the efficacy of TP receptor blockers for bronchial asthma through the experimental results reported was discussed."
06/01/2015 - "The findings suggest applications for TP receptor antagonists in cases of asthma with high levels of cysLT production. "
11/01/2011 - "Therefore, a TP receptor antagonist can be useful in combination treatment of allergic responses in asthma."
06/01/2003 - "However, simultaneous blockade of leukotriene and thromboxane receptors almost completely prevented the early allergic response in the precision-cut lung slices from all individuals, suggesting such a dual treatment as a potential future asthma therapy."
06/01/2011 - "TP receptor knockout mice-that lack F(2)-isoprostanes and thromboxane A(2) signalling-and wild-type control mice underwent 30 min of renal ischemia and 24 h of reperfusion. "
03/01/2006 - "We analyzed the involvement of thromboxane (TX) A2/prostaglandin (PG) H2 (TP) receptor in ischemia-induced neovascularization in mice. "
09/01/1983 - "Thus, specific inhibition of TxA2 synthesis without thromboxane receptor antagonism can exert a protective effect on the myocardium during ischemia in cats."
09/04/1987 - "[Myocardial resting ischemia after intravenous infusion of a thromboxane-receptor antagonist]."
09/01/1993 - "The myocardial salvage efficacy of a thromboxane A2/prostaglandin endoperoxide (TP) receptor antagonist has not been previously determined in a ferret model of ischemia and reperfusion. "
05/01/1990 - "Protective effects of the specific thromboxane receptor antagonist (+)-S145Na in splanchnic artery occlusion shock in rats."
07/01/1988 - "Protective effects of thromboxane receptor blockade in splanchnic artery occlusion shock."
09/01/2004 - "These results demonstrate that renal vasoconstriction during endotoxemic shock induced by LPS is mediated by TP receptors as indicated by pharmacologic blockade and genetic disruption of TP receptors."
08/01/1994 - "These data suggest that this thromboxane receptor antagonist might be a useful drug in shock conditions."
07/01/1989 - "These data demonstrate that thromboxane receptor stimulation is a pivotal step in the pulmonary manifestations of sublethal Forssman shock but is less crucial in more severe forms of the reaction."
|1.||Aspirin (Acetylsalicylic Acid)
|2.||Thromboxane Receptors (Thromboxane Receptor)
|4.||Thromboxane A2 (A2, Thromboxane)
|7.||3- ((6- amino- (4- chlorobenzenesulfonyl)- 2- methyl- 5,6,7,8- tetrahydronapht)- 1- yl)propionic acid