|1.||Huang, Leaf: 12 articles (07/2013 - 11/2004)|
|2.||Elsinga, Philip H: 9 articles (10/2015 - 11/2004)|
|3.||Ishiwata, Kiichi: 9 articles (10/2015 - 11/2004)|
|4.||van Waarde, Aren: 8 articles (10/2015 - 11/2004)|
|5.||Matsumoto, Rae R: 7 articles (11/2014 - 06/2002)|
|6.||Shiba, Kazuhiro: 5 articles (11/2015 - 08/2007)|
|7.||Cuevas, Javier: 5 articles (01/2013 - 06/2002)|
|8.||Li, Shyh-Dar: 5 articles (10/2008 - 09/2006)|
|9.||Maslov, L N: 5 articles (03/2004 - 03/2000)|
|10.||Lishmanov, Iu B: 5 articles (03/2004 - 03/2000)|
|1.||Schizophrenia (Dementia Praecox)
10/21/2003 - "An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. "
07/01/1999 - "Studies on the sigma receptor and related compounds are becoming more attractive since they were found to be closely related to higher brain functions such as memory, learning, depression, anxiety, schizophrenia and neuroprotection. "
01/01/1993 - "sigma Receptors were reported to be altered in schizophrenia in certain studies, and up- and downregulations of sigma receptors have been observed in certain conditions. "
08/01/2004 - "Lack of association between sigma receptor gene variants and schizophrenia."
10/21/2003 - "Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. "
05/01/2006 - "In addition, the efficacy of sigma receptors for stroke treatment at delayed time points is likely the result of combined neuroprotective and anti-inflammatory properties of these receptors."
11/01/2008 - "The ability to control ionic imbalances and Ca2+ dysregulation evoked by ASIC1a activation makes sigma receptors an attractive target for ischemic stroke therapy."
05/01/2006 - "Thus, our results demonstrate that the sigma receptor-selective agonist, DTG, can enhance neuronal survival when administered 24 hr after an ischemic stroke. "
12/01/2009 - "Human umbilical cord blood cell (HUCBC) and the sigma receptor agonist 1,3, di-o-tolylguanidine (DTG) administration both caused significant reductions in brain damage in the rat middle cerebral artery occlusion model of stroke when administered at delayed timepoints. "
11/15/2014 - "Mounting evidence indicate that targeting sigma receptors may be particularly beneficial in a number of neurodegenerative conditions including Alzheimer׳s disease, Parkinson׳s disease, stroke, methamphetamine neurotoxicity, Huntington׳s disease, amyotrophic lateral sclerosis, and retinal degeneration. "
12/01/2006 - "Our studies show that activation of sigma receptors can ameliorate [Ca(2+)](i) dysregulation associated with ischemia in cortical neurons and, thus, identify one of the mechanisms by which these receptors may exert their neuroprotective properties."
12/01/2006 - "Sigma receptors are putative targets for neuroprotection following ischemia; however, little is known on their mechanism of action. "
11/01/1996 - "Because PPBP afforded protection when administered at the end of ischemia and during reperfusion, sigma-receptors may influence the progression of injury in ischemic border regions."
11/01/1996 - "These data indicate that sigma-receptors may play an important role in the mechanism of injury both in cortex and striatum after 2 hours of transient focal ischemia in rats. "
09/01/1995 - "Because PPBP afforded protection when administered at the end of ischemia and during reperfusion, sigma-receptors may contribute to the progression of injury in ischemic border regions."
|4.||Mood Disorders (Mood Disorder)
01/01/1996 - "The possible implication of sigma receptors in affective disorders has also been suggested by reports showing that some antidepressant drugs have a high affinity for sigma receptors and that long-term treatments with anti- depressant drugs, even with those devoid of affinity for sigma receptors, modify their binding characteristics. "
07/01/1999 - "These findings suggest that sigma receptors are involved in stress-induced pathophysiological changes such as depression and anxiety and that phenytoin-sensitive sigma1-receptor ligands are useful for the treatment of affective disorders, particularly those considered to be treatment-resistant."
11/01/2004 - "In this review, we try to summarize the behavioral effects of sigma receptor ligands that have been described, and their activity in animal models related to some brain disorders, especially schizophrenia and affective disorders."
05/01/2013 - "Sigma receptors are involved in several central nervous system (CNS) disorders, including mood disorders (depression and anxiety), psychosis, schizophrenia, movement disorders (i.e., Parkinson's disease) and memory deficits (i.e., Alzheimer's disease). "
|5.||Lung Neoplasms (Lung Cancer)
09/01/2006 - "Human lung cancer cells often overexpress the sigma receptor and, thus, can be targeted with a specific ligand such as anisamide. "
07/01/2013 - "Lipid-calcium-carbonate (LCC) nanoparticles were conjugated with anisamide, a targeting ligand for the sigma receptor which is expressed on lung cancer cells. "
01/30/2012 - "EV was loaded onto LPH nanoparticles that are comprised of a membrane/core structure including a surface-grafted polyethylene glycol (PEG) used to evade the reticuloendothelial system (RES) and anisamide (AA) for targeting the sigma receptor over-expressed in H460 human lung cancer cells. "
02/28/2012 - "The sub-cellular distribution studied in the sigma receptor positive human H460 lung cancer cells indicated that LCP-II could release more cargo to the cytoplasm than our previous lipid/protamine/DNA (LPD) formulation, leading to a significant (~40 fold in vitro and ~4 fold in vivo) improvement in siRNA delivery. "
|2.||sigma Receptors (sigma Receptor)
|6.||Antipsychotic Agents (Antipsychotics)
|8.||Small Interfering RNA (siRNA)
|9.||DNA (Deoxyribonucleic Acid)
|2.||Drug Therapy (Chemotherapy)
|3.||Heterologous Transplantation (Xenotransplantation)