Phencyclidine Receptors

Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.

Also Known As:

Networked: 22 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ahmadi, Abbas: 1 article (01/2014)
2.	Ghadiri, Afsane: 1 article (01/2014)
3.	Khalili, Mohsen: 1 article (01/2014)
4.	Marami, Sara: 1 article (01/2014)
5.	Nahri-Niknafs, Babak: 1 article (01/2014)
6.	Stanojlovic, O: 1 article (05/2001)
7.	Susic, V: 1 article (05/2001)
8.	Zivanovic, D: 1 article (05/2001)

Related Diseases

1.	Neuroblastoma 04/20/1990 - "The mouse neuroblastoma-Chinese hamster brain hybrid cell line NCB-20 is the only clonal cell line in which binding studies indicate the presence of phencyclidine (PCP) receptor-like sites. " 03/01/1989 - "The mouse neuroblastoma--Chinese hamster brain hybrid cell line NCB-20 is the only clonal cell line in which binding studies indicate the presence of phencyclidine (PCP) receptors. " 11/01/1988 - "Characterization of opioid, sigma, and phencyclidine receptors in the neuroblastoma-brain hybrid cell line NCB-20." 11/01/1988 - "Opioid, sigma, and phencyclidine (PCP) receptors were characterized in the mouse neuroblastoma--Chinese hamster brain hybrid cell line NCB-20. "
2.	Intracranial Vasospasm 02/01/1983 - "This study provides direct evidence for a distinct PCP receptor on cerebral blood vessels and suggests that certain benzomorphans may produce cerebral vasospasm via PCP-receptor interactions." 11/01/1989 - "This study provides direct evidence for PCP receptors on cerebral blood vessels, and suggests that PCP may produce cerebral vasospasm via PCP receptor interaction."
3.	Reflex Epilepsy (Photosensitive Epilepsy) 05/01/2001 - "Metaphit induces a generalized, reflex epilepsy thus providing an experimental model of choice for the studies of the mechanism of epilepsy development and blockade of NMDA/PCP receptors. "
4.	Spasm (Spasms) 01/01/1990 - "Recently, it was found in studies in vitro and in vivo that phencyclidine hydrochloride (PCP, 'angel dust') can induce cerebral arterial and arteriolar spasms, in psychotomimetic concentrations, by acting on specific PCP receptors, which is followed by rupture of cerebral and postcapillary venules. "
5.	Rupture 01/01/1990 - "Recently, it was found in studies in vitro and in vivo that phencyclidine hydrochloride (PCP, 'angel dust') can induce cerebral arterial and arteriolar spasms, in psychotomimetic concentrations, by acting on specific PCP receptors, which is followed by rupture of cerebral and postcapillary venules. " 01/01/1990 - "We wondered whether a chemical substance which has the ability to block Ca2+ channels, neurotransmitter release, intracellular Ca2+ release and the NMDA-glutamate receptor channel, viz., Mg2+, might block the PCP receptor which subserves cerebral contractile events and thereby prevent rupture of microvessels. "

Related Drugs and Biologics

1.	Phencyclidine (Angel Dust)
2.	Phencyclidine Receptors
3.	N-Methylaspartate (NMDA)
4.	metaphit
5.	Benzomorphans
6.	sigma Receptors (sigma Receptor)
7.	Ligands
8.	Dopamine (Intropin)
9.	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)
10.	Raclopride

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Controlled Hypotension