Phencyclidine Receptors
Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.
Also Known As:
Receptors, Phencyclidine; PCP Receptor; Phencylidine Receptor; Receptor, PCP; Receptor, Phencylidine; PCP Receptors; Receptors, PCP
Networked: 22
relevant articles (0 outcomes,
6 trials/studies)
Bio-Agent Context: Research Results
Experts
Related Diseases
1. | Neuroblastoma
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2. | Intracranial Vasospasm
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3. | Reflex Epilepsy (Photosensitive Epilepsy)
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4. | Spasm (Spasms)
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5. | Rupture
01/01/1990
- " Recently, it was found in studies in vitro and in vivo that phencyclidine hydrochloride (PCP, 'angel dust') can induce cerebral arterial and arteriolar spasms, in psychotomimetic concentrations, by acting on specific PCP receptors, which is followed by rupture of cerebral and postcapillary venules. " 01/01/1990
- " We wondered whether a chemical substance which has the ability to block Ca2+ channels, neurotransmitter release, intracellular Ca2+ release and the NMDA-glutamate receptor channel, viz., Mg2+, might block the PCP receptor which subserves cerebral contractile events and thereby prevent rupture of microvessels. "
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