|1.||Xia, Qiang: 8 articles (08/2010 - 05/2004)|
|2.||Nakao, Kaoru: 7 articles (11/2010 - 04/2004)|
|3.||Wong, T M: 7 articles (02/2007 - 08/2000)|
|4.||Prisinzano, Thomas E: 6 articles (12/2015 - 03/2009)|
|5.||Wong, Tak Ming: 6 articles (02/2012 - 04/2003)|
|6.||Mochizuki, Hidenori: 5 articles (11/2010 - 04/2008)|
|7.||Maslov, L N: 5 articles (06/2008 - 01/2001)|
|8.||Kieffer, Brigitte L: 4 articles (11/2015 - 02/2003)|
|9.||Ikeda, Ken: 4 articles (11/2010 - 04/2008)|
|10.||Kurokawa, Takahiro: 4 articles (10/2009 - 08/2005)|
05/01/1998 - "The present results provide further evidence that kappa-opioid receptor agonists significantly attenuate visceral nociception and, in conjunction with other information, suggest that a peripherally restricted kappa-opioid receptor agonist would be therapeutically effective in relieving visceral pain."
05/01/1998 - "The objective of this study was to evaluate the effects of kappa-opioid receptor agonists on pressor and visceromotor responses to colorectal distension in awake, unrestrained rats, a model of visceral pain. "
11/01/2015 - "Activation of kappa opioid receptors (KORs) expressed by peripheral sensory neurons that respond to noxious stimuli (nociceptors) can reduce neurotransmission of pain stimuli from the periphery to the central nervous system. "
08/19/2015 - "Kappa opioid receptor (KOR) modulation is a promising target for drug discovery efforts due to KOR involvement in pain, depression, and addiction behaviors. "
02/15/2015 - "Kappa opioid receptor (KOR) is an important mediator of pain signaling and it is targeted for the treatment of various pains. "
|2.||Substance-Related Disorders (Drug Abuse)
01/02/2004 - "The improved synthetic method-the overall yield was increased about 3-fold-combined with the practical methodology to determine optical purity will considerably facilitate the employment of these enantiomers as pharmacological tools for examination of the kappa-opioid receptor system, as well as their evaluation as drug abuse treatment agents. "
12/01/2015 - "Differential modulation of kappa opioid receptor (KOR) signaling has been a proposed strategy for developing therapies for drug addiction and depression by either activating or blocking this receptor. "
10/01/2015 - "Kappa opioid receptor (KOR) signaling has been implicated in mediating behavioral and biochemical effects associated with drug dependence. "
06/01/2010 - "Initial hypotheses regarding the role of the kappa opioid system in drug addiction suggested that kappa receptor stimulation had anti-addictive effects. "
03/27/2009 - "This review will detail recent progress in a program directed toward investigating psychoactive natural products with the goal of treating drug abuse by targeting kappa opioid receptors."
09/01/2012 - "Studies suggest that pruritus may arise from an imbalance of the mu- and kappa-opioid receptor system activity in either the skin or the central nervous system. "
12/01/2015 - "The kappa opioid receptor (KOR) is involved in mediating pruritus; agonists targeting this receptor have been used to treat chronic intractable itch. "
12/01/2015 - "Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus."
09/01/2012 - "The aim of this review is to provide an overview of the promising role of kappa- opioid receptors and their agonist in the pathophysiology and treatment of pruritus."
09/01/2012 - "Stimulation of kappa-opioid receptors by their agonists inhibits pruritus in both animals and humans. "
|4.||Spinal Cord Injuries (Spinal Cord Injury)
02/01/2004 - "These results suggest that the kappa opioid receptor system is related to DSD caused by spinal cord injury. "
09/01/1985 - "WIN44,441-3 (WIN(-], an opiate antagonist with enhanced activity at the kappa-receptor, reduced motor dysfunction after ischemic spinal cord injury. "
10/29/1993 - "U-50488H, a selective opioid kappa receptor agonist has been shown to be a neuroprotective agent in animal models of spinal cord injury. "
12/01/1987 - "Beneficial effects of the kappa opioid receptor agonist U-50488H in experimental acute brain and spinal cord injury."
01/01/1986 - "In addition, spinal cord trauma in rats is associated with increased concentrations of the endogenous kappa agonist dynorphin A, and increased kappa opioid receptor binding capacity localized to the injury site. "
02/01/2012 - "This study demonstrates that local activation of kappa opioid receptors decreases two important parameters of temporomandibular joint inflammation, that is, plasma extravasation and neutrophil migration, in a dose-dependent and antagonist-reversible manner. "
02/01/2012 - "Local kappa opioid receptor activation decreases temporomandibular joint inflammation."
06/01/2008 - "Inflammation-induced changes in rostral ventromedial medulla mu and kappa opioid receptor mediated antinociception."
08/01/2003 - "These results suggest that local transcriptional and post-transcriptional changes of the delta- and kappa-opioid receptors genes could be responsible for the enhanced antisecretory effects of delta- and kappa-opioid agonists during intestinal inflammation."
08/01/2003 - "The kappa-opioid receptors gene transcription was not altered by inflammation, whereas kappa-opioid receptors protein levels were significantly enhanced in the SP/M preparation. "
|1.||kappa Opioid Receptors (kappa Opioid Receptor)
|5.||(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide
|8.||Opioid Analgesics (Opioids)
|10.||Analgesics (Analgesic Drugs)
|2.||Transcutaneous Electric Nerve Stimulation (TENS)
|5.||Renal Dialysis (Hemodialysis)