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Fibronectin Receptors

Specific cell surface receptors which bind to FIBRONECTINS. Studies have shown that these receptors function in certain types of adhesive contact as well as playing a major role in matrix assembly. These receptors include the traditional fibronectin receptor, also called INTEGRIN ALPHA5BETA1 and several other integrins.
Also Known As:
Receptors, Fibronectin
Networked: 34 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Zeng, Zhao-Zhu: 2 articles (10/2011 - 12/2004)
2. Livant, Donna L: 2 articles (10/2011 - 12/2004)
3. van Hoorn, Hedde: 1 article (04/2015)
4. Schmidt, Thomas: 1 article (04/2015)
5. Danen, Erik H J: 1 article (04/2015)
6. Balcioglu, Hayri E: 1 article (04/2015)
7. Donato, Dominique M: 1 article (04/2015)
8. Ben-Josef, Edgar: 1 article (10/2011)
9. Staszewski, Evan D: 1 article (10/2011)
10. Spalding, Aaron C: 1 article (10/2011)

Related Diseases

1. Neoplasms (Cancer)
2. Glioma (Gliomas)
03/01/1993 - "Comparison of the model with data at 37 degrees C suggests that while cytoskeletal cross-linking and clustering of fibronectin receptors significantly increases adhesion strength, specific glioma cell-substratum attachment sites possess little mechanical rigidity and detach through a peeling mechanism, consistent with the view that these sites of < or = 15 nm cell-substrate separation are precursors to fully formed, elastically rigid focal contacts."
10/03/1994 - "Localization of vitronectin- and fibronectin-receptors on cultured human glioma cells."
03/01/1993 - "Our model successfully predicts the observed detachment forces at 4 degrees C and yields values for the number of fibronectin receptors per glioma cell and the density of cytoskeletal connection molecules (talin) involved in receptor clusters which are consistent with measurements for other cell types. "
11/01/1998 - "Four glioma cells derived from GB whose tumor cells did not positively stain for fibronectin receptors migrated much less extensively to fibronectin than other glioma cells whose tissues showed positive staining for the fibronectin receptor. "
06/19/1992 - "All cell lines tested expressed alpha V beta 1. Human neuroblastoma cells, the majority of which are N-type cells with very low alpha 5 beta 1 expression, are also contrasted with other childhood cancer cells (rhabdomyosarcoma, Ewing's sarcoma, and glioma), all of which expressed high levels of alpha 5 beta 1. The characteristic expression of integrin fibronectin receptors may account for the clinically unique tumor behavior, and the immunohistochemical staining for integrins may become a useful alternative to conventional histology in differential diagnosis and a marker for prognosis in neuroblastoma."
3. Wounds and Injuries (Trauma)
4. Melanoma (Melanoma, Malignant)
5. Lymphoma (Lymphomas)

Related Drugs and Biologics

1. Fibronectins (Fibronectin)
2. Vitronectin
3. Integrins
4. Integrin alpha5beta1
5. Integrin alpha4beta1 (VLA-4)
6. Laminin Receptors
7. phorbol
8. Integrin alphaVbeta3
9. Collagen Receptors
10. Tenascin

Related Therapies and Procedures

1. Antibiotic Prophylaxis