delta Opioid Receptors (delta Opioid Receptor)

A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.

Also Known As:

delta Opioid Receptor; Receptor, delta; Receptors, Opioid, delta; delta Receptor; Opioid Receptor, delta; Receptor, delta Opioid; Opioid Receptors, delta; Receptors, delta; Receptors, delta Opioid; delta Receptors

Networked: 693 relevant articles (21 outcomes, 75 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kieffer, Brigitte L: 15 articles (10/2020 - 02/2003)
2.	Pradhan, Amynah A: 10 articles (01/2021 - 10/2011)
3.	Xia, Ying: 10 articles (12/2018 - 07/2005)
4.	Balboni, Gianfranco: 8 articles (12/2021 - 12/2002)
5.	Maslov, L N: 8 articles (10/2006 - 09/2000)
6.	Maldonado, Rafael: 7 articles (01/2021 - 02/2003)
7.	Gaveriaux-Ruff, Claire: 6 articles (01/2022 - 06/2011)
8.	Pol, Olga: 6 articles (12/2021 - 08/2003)
9.	Massotte, Dominique: 6 articles (01/2020 - 01/2009)
10.	Matifas, Audrey: 6 articles (02/2015 - 02/2003)

Related Diseases

1.	Pain (Aches) 01/01/2022 - "These results also suggest that development of peripherally-restricted kappa or delta opioid receptor agonists may provide safer and effective pain relief for the elderly." 01/01/2020 - "Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain." 01/01/2022 - "Research studies suggest delta opioid receptor (DOR) may be involved in modulating pain as well as depression. " 12/01/2008 - "This study examined the association between pressure pain sensitivity and various single nucleotide polymorphisms (SNPs) of human micro-, kappa-, and delta-opioid receptor (i.e. " 11/05/2021 - "The delta opioid receptor (DOR) is a crucial receptor system that regulates pain, mood, anxiety, and similar mental states. "
2.	Hyperalgesia 10/01/2016 - "Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57BL/6 mice." 11/24/2010 - "Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat." 05/01/2008 - "In contrast, mechanical allodynia and thermal hyperalgesia were both markedly augmented in delta-receptor mutants, indicating a role for an endogenous delta-receptor tone in the control of inflammatory pain. " 08/01/2007 - "Spinal administration of a delta opioid receptor agonist attenuates hyperalgesia and allodynia in a rat model of neuropathic pain." 01/10/2007 - "The present results suggest that thermal hyperalgesia in experimental neuropathic pain can be reduced through activation of peripheral delta-opioid receptors. "
3.	Fibromyalgia (Fibrositis) 07/01/2007 - "Up-regulation of delta-opioid receptors and kappa-opioid receptors in the skin of fibromyalgia patients." 03/01/2011 - "Although there is no known cure for fibromyalgia, multidisciplinary team efforts using combined treatment approaches, including patient education, aerobic exercise, cognitive behavioral therapy, and pharmacologic therapies (serotonin norepinephrine reuptake inhibitors [e.g., duloxetine, milnacipran] and alpha 2-delta receptor ligands [e.g., pregabalin]) might improve symptoms as well as function in patients with fibromyalgia." 07/01/2010 - "Although there is no known cure for fibromyalgia, multidisciplinary team efforts using combined treatment approaches, including patient education, aerobic exercise, cognitive behavioral therapy, and pharmacologic therapies (serotonin norepinephrine reuptake inhibitors [eg, duloxetine, milnacipran] and alpha 2-delta receptor ligands [eg, pregabalin]) may improve symptoms as well as function of patients with fibromyalgia."
4.	Ischemia 04/12/1991 - "Changes in striatal mu and delta opioid receptors after transient forebrain ischemia: a quantitative autoradiographic study." 01/01/2014 - "Activation of peripheral delta opioid receptors increases cardiac tolerance to arrhythmogenic effect of ischemia/reperfusion." 06/01/2010 - "Delta opioid receptor (DOR) activation is a versatile, evolutionarily conserved, endogenous neuroprotective mechanism that blocks several steps in the deleterious cascade of neurological events during ischemia. " 06/01/2010 - "Protecting motor networks during perinatal ischemia: the case for delta-opioid receptors." 10/01/2006 - "[Delta-opioid receptor activation prevents appearance of irreversible damages of cardiomyocytes and exacerbates myocardial contractility dysfunction during ischemia and reperfusion]."
5.	Neuroblastoma 06/19/2003 - "After transfection of the human wild type delta receptor (hdelta(wt)) into NG 108-15 rodent neuroblastoma-derived cells, HEK 293 human embryonic kidney cells and NIH 3T3 mouse fibroblasts, all these cell types produced hdelta(deltaICD3). " 06/19/2003 - "In addition to the established human delta opioid receptor SH-SY5Y neuroblastoma cells produce an atypical, shorter, form of this receptor which is predicted to lack the third intracellular domain. " 06/19/2003 - "A truncated delta opioid receptor, spontaneously produced in human but not rat neuroblastoma cells, interferes with signaling of the full-length receptor." 04/01/2000 - "Internalization, recycling, and resensitization of the human delta-opioid receptor (hDOR) were studied in the neuroblastoma cell line SK-N-BE, endogenously expressing this receptor. " 04/04/1997 - "Characterization of the delta-opioid receptor found in SH-SY5Y neuroblastoma cells."

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Enkephalins
3.	Ligands
4.	Serotonin (5 Hydroxytryptamine)
5.	Duloxetine Hydrochloride (Cymbalta)
6.	Norepinephrine (Noradrenaline)
7.	Milnacipran (Ixel)
8.	Pregabalin (Lyrica)
9.	mu Opioid Receptors (mu Opioid Receptor)
10.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Therapeutics
2.	Analgesia
3.	Cardiopulmonary Resuscitation (CPR)
4.	Pneumonectomy (Lung Volume Reduction)
5.	Aftercare (After-Treatment)