Photoallergic Dermatitis (Photoallergy)

A delayed hypersensitivity involving the reaction between sunlight or other radiant energy source and a chemical substance to which the individual has been previously exposed and sensitized. It manifests as a papulovesicular, eczematous, or exudative dermatitis occurring chiefly on the light-exposed areas of the skin.

Also Known As:

Photoallergy; Photocontact Dermatitis; Dermatitis, Photoallergic; Photoallergic Contact Dermatitis; Photosensitive Contact Dermatitis; Contact Dermatitides, Photoallergic; Contact Dermatitides, Photosensitive; Contact Dermatitis, Photoallergic; Contact Dermatitis, Photosensitive; Dermatitides, Photoallergic; Dermatitides, Photoallergic Contact; Dermatitides, Photocontact; Dermatitides, Photosensitive Contact; Dermatitis, Photoallergic Contact; Dermatitis, Photosensitive Contact; Photoallergic Contact Dermatitides; Photoallergic Dermatitides; Photoallergies; Photocontact Dermatitides; Photosensitive Contact Dermatitides; Dermatitis, Contact, Photoallergic; Dermatitis, Contact, Photosensitive; Dermatitis, Photocontact

Networked: 402 relevant articles (4 outcomes, 29 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Phototoxic Dermatitis (Phototoxicity)
2.	Hypersensitivity (Allergy)
3.	Allergic Contact Dermatitis
4.	Contact Dermatitis (Eczema, Contact)
5.	Photosensitivity Disorders (Photodermatitis)

Experts

1.	Api, A M: 17 articles (12/2013 - 09/2012)
2.	Letizia, C S: 17 articles (12/2013 - 09/2012)
3.	Scognamiglio, J: 16 articles (12/2013 - 09/2012)
4.	Jones, L: 10 articles (10/2012 - 09/2012)
5.	Tokura, Yoshiki: 9 articles (12/2021 - 08/2003)
6.	Fonseca, E: 5 articles (10/2009 - 09/2001)
7.	Bruze, Magnus: 4 articles (04/2022 - 02/2004)
8.	Atarashi, Kenji: 4 articles (08/2012 - 02/2006)
9.	Lhiaubet-Vallet, Virginie: 3 articles (09/2022 - 07/2009)
10.	Foti, Caterina: 3 articles (01/2022 - 06/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Photoallergic Dermatitis:

1.	Sunscreening Agents (Sunscreens)IBA 07/01/2014 - "Photopatch testing is helpful to determine suspected topical agent photoallergies (eg, from ultraviolet filters in sunscreens) but generally not helpful in detecting systemic drug photosensitivity. " 08/01/2006 - "The results of this study confirm that sunscreens are the more frequently involved substances in photoallergic contact dermatitis in our population. " 03/01/2011 - "However, many molecular sunscreens penetrate into the skin causing photoallergies, phototoxic reactions and skin irritation. " 07/01/2010 - "True photoallergy to sunscreens is rare despite popular belief." 11/01/2008 - "Although rarely observed, we here describe the occurrence of a photoallergic contact dermatitis in a 55-year-old man after the use of two different sunscreens. "
2.	musk ambrette (artificial)IBA 07/01/1982 - "This study reports an improved experimental guinea pig model for inducing photoallergic contact dermatitis to musk ambrette. " 11/01/1982 - "This study reports a photoallergic contact dermatitis to musk ambrette in two male patients. " 03/01/1991 - "Pigmented photoallergic contact dermatitis from musk ambrette." 03/01/1987 - "Lichenoid photocontact dermatitis to musk ambrette." 12/01/1986 - "Contact photoallergy to musk ambrette."
3.	cytoplasmic protein A (PACD)IBA 11/01/2023 - "Photopatch testing represents the gold standard for the diagnosis of photoallergic contact dermatitis (PACD). " 12/01/2023 - "Certain chemicals and/or their byproducts are photoactivated by UV/VIS and trigger a dermal allergenic response, clinically recognized as photoallergic contact dermatitis (PACD). " 09/01/2021 - "The diagnosis of photoallergic contact dermatitis (PACD) is confirmed by photopatch testing (PPT). " 07/01/2021 - "To update current information on the prevalence of photoallergic contact dermatitis (PACD) to 20 photoallergens and their clinical relevance in the Chinese context. " 07/01/2015 - "Photoallergic contact dermatitis (PACD) is an uncommon condition, and there is a lack of validated criteria for its diagnosis. "
4.	heptakis(2,6- O- dimethyl)beta- cyclodextrinIBA 01/01/1989 - "The present results indicate that DM-beta-CyD is particularly effective in alleviating photoallergic contact dermatitis due to CPZ." 01/01/1989 - "The effects of topically applied beta-cyclodextrin (beta-CyD) and heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CyD) on photoallergic contact dermatitis due to chlorpromazine hydrochloride (CPZ) were investigated using the photomaximization technique in guinea pigs. "
5.	Ketoprofen (Orudis)FDA LinkGeneric 02/01/2001 - "Five cases of photocontact dermatitis due to topical ketoprofen: photopatch testing and cross-reaction study." 11/01/2022 - "Moreover, ketoprofen contaminates clothing, shoes, and bandages, and some cases of photoallergy relapses have been reported that were induced by ketoprofen-contaminated objects after they were used again in the presence of UV radiation (5,6). " 06/01/2019 - "Ketoprofen-induced photoallergic dermatitis." 12/01/2016 - "In conclusion, photoallergic dermatitis is a significant adverse effect of ketoprofen. " 12/01/2016 - "Ketoprofen-induced photosensitivity reactions usually present as photoallergic dermatitis, which is a cell-mediated immune process. "
6.	Chlorpromazine (Thorazine)FDA Link 01/01/1970 - "[In vitro studies on chlorpromazine photoallergy]." 08/01/2020 - "Allergic and photoallergic contact dermatitis to chlorpromazine." 07/01/2015 - "Photoallergic Contact Dermatitis Due to Chlorpromazine: A Report of 2 Cases." 11/01/1975 - "Chlorpromazine photoallergy. " 08/01/2020 - "We present a series of photoallergic contact dermatitis and ACD to chlorpromazine diagnosed at a tertiary centre cutaneous allergy unit between 1980 and 2019."
7.	benzophenoneIBA 03/01/2019 - "Three cases of photoallergic contact dermatitis induced by benzophenone in amusement park wristbands." 06/01/1989 - "Photoallergy to benzophenone." 07/01/1982 - "[Photoallergic contact dermatitis by benzophenone containing sunscreening preparations]." 01/01/2020 - "Photoallergic contact dermatitis due to benzophenone contained in swimming goggles." 04/01/2022 - "Allergic contact dermatitis (ACD) and photoallergic contact dermatitis (PACD) to benzophenone present in printing ink have been reported. "
8.	Minocycline (Cyclops)FDA LinkGeneric 06/01/2020 - "Cutaneous AEs were uncommon, and findings from a dermal safety study showed that topical minocycline foam 4% did not have any effects related to phototoxicity, photoallergy, skin sensitization and skin irritation. " 12/01/2019 - "Topical minocycline foam 4%: Results of four phase 1 studies evaluating the potential for phototoxicity, photoallergy, sensitization, and cumulative irritation." 07/01/2014 - "A PubMed review of published article titles and abstracts was performed using the search term Laser with each of the following terms individually: photosensitive, photosensitiser, photosensitizer, phototoxicity, photoallergy, complications, case-report, tetracycline, minocycline, amiodarone, nitrofurantoin and medication. "
9.	Peptides (Polypeptides)IBA 12/01/2021 - "Therefore, this study aimed to develop an in chemico photoallergy testing method, photo-direct peptide reactivity assay (photo-DPRA). " 11/01/2001 - "Furthermore, epicutaneous application of the ofloxacin-photoconjugated peptide was able to prime mice for subsequent elicitation of photoallergy evoked with systemic ofloxacin and ultraviolet A light. " 11/01/2001 - "This study suggests that lysine affords quinolone photocoupling of peptides and quinolone-photomodified peptides on class II molecules stimulate pathogenetic T cells in quinolone photoallergy." 11/01/2001 - "Quinolone-photoconjugated major histocompatibility complex class II-binding peptides with lysine are antigenic for T cells mediating murine quinolone photoallergy."
10.	Quinidine (Chinidin)FDA LinkGeneric 10/01/1988 - "Photoallergy to systemic quinidine in the mouse: dose-response studies." 08/01/2017 - "Photoallergic contact dermatitis caused by quinidine sulfate in a caregiver." 08/01/1991 - "Ultraviolet B irradiation inhibits the induction of photoallergy to systemically administered quinidine in the mouse." 03/01/1991 - "Photoallergies due to quinidine sulphate were described as early as 1942. " 03/01/1991 - "[Quinidine-induced photoallergy. "

Therapies and Procedures

1.	Topical Administration 12/01/2019 - "Four single-center, randomized, controlled, within-subject comparison studies were conducted to evaluate the potential for phototoxicity, photoallergy, skin sensitization, and cumulative skin irritation with topical administration of FMX101 4% and the corresponding vehicle. " 04/25/2014 - "To assess the drug concentrations and elimination rate of ketoprofen in the stratum corneum following topical administration of two different formulations in human subjects for reference in the risk management of photocontact dermatitis caused by topical ketoprofen. "
2.	Photopheresis 07/01/1996 - "Photopheresis; the risk of photoallergy." 07/01/1996 - "Whether the presence of plasma during photopheresis is a risk for photoallergy was investigated with 8-MOP and chlorpromazine (CPZ; well-established photoallergen). "
3.	Tattooing 06/01/2020 - "Pigments are widely used for tattoos, and hypersensitivity reactions, such as photoallergic dermatitis, are possible tattoo-related complications. "
4.	PUVA Therapy 11/01/1977 - "In nine of 121 patients unusual side effects of PUVA-therapy were observed: hypertrichosis, subungual hemorrhage of fingernails, nevus spilus-like hyperpigmentation, acneiform eruptions, and a photoallergic dermatitis to 8-methoxypsoralen."
5.	Phototherapy (Light Therapy) 02/01/2002 - "A brief overview of phototoxicity, photoallergy, and photoprotection is discussed with further elaboration upon the principles of phototherapy and its utility in treating idiopathic photodermatoses."