Dopamine D2 Receptors (Dopamine D2 Receptor)

A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.

Also Known As:

Networked: 1294 relevant articles (43 outcomes, 194 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seeman, Philip: 14 articles (01/2021 - 06/2005)
2.	Uchida, Hiroyuki: 12 articles (01/2022 - 08/2008)
3.	Okubo, Yoshiro: 11 articles (05/2022 - 01/2002)
4.	Kellendonk, Christoph: 9 articles (01/2022 - 08/2009)
5.	Suzuki, Takefumi: 9 articles (01/2022 - 04/2012)
6.	Becu-Villalobos, Damasia: 8 articles (01/2022 - 11/2007)
7.	Pollock, Bruce G: 8 articles (01/2022 - 12/2009)
8.	Mimura, Masaru: 8 articles (10/2020 - 04/2012)
9.	Suhara, Tetsuya: 8 articles (11/2017 - 01/2002)
10.	Pertovaara, Antti: 8 articles (10/2014 - 09/2002)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/27/2012 - "In treating schizophrenia, it has been established that 65-80% occupancy of dopamine D2 receptors optimizes therapeutic efficacy while minimizing risks of extrapyramidal symptoms. " 04/01/2015 - "Estimated dopamine D2 receptor occupancy and remission in schizophrenia. " 11/23/2023 - "Successful phase 3 trials of KarXT in people with schizophrenia herald a new era of treating the disorder with drugs that do not target the dopamine D2 receptor. " 11/01/2017 - "The present study indicates the possibilities of: (1) a higher proportion of D2High in the putamen despite unaltered amounts of total dopamine D2 receptors; and (2) associations between depressive symptoms and amounts of caudate dopamine D2 receptors in patients with schizophrenia." 11/07/2014 - "Many studies have reported associations between the C957T and C939T polymorphisms in Dopamine D2 receptor (DRD2) gene and schizophrenia, but results are inconsistent. "
2.	Parkinson Disease (Parkinson's Disease) 01/01/2014 - "Dopamine D2 receptor agonists represent a first line treatment option in young patients with signs and symptoms of idiopathic Parkinson's disease. " 01/01/2022 - "Brain imaging studies have highlighted that the density of dopamine D2 receptors markedly fluctuates across the stages of Parkinson's disease and in response to pharmacological treatment. " 08/25/2019 - "The aim of the present study was to reveal the role of cortical-striatum postsynaptic dopamine D2 receptor (D2R) in improving motor behavioral dysfunction in Parkinson's disease (PD) mice by exercise. " 01/01/2003 - "The aim of this study was to estimate the impact of stereotactic pallidal surgery on the binding potential of dopamine D2 receptors in patients with advanced Parkinson disease (PD). " 01/01/2003 - "The impact of stereotactic pallidal surgery on the dopamine D2 receptor in Parkinson disease: a positron emission tomography study."
3.	Psychotic Disorders (Schizoaffective Disorder) 01/01/2000 - "[The study of polymorphism of dopamine D2 receptor gene in men from different ethnic groups with acute alcoholic psychosis]." 01/23/2021 - "The role of the dopamine D2 receptor is central to the idea of psychosis. " 10/04/2016 - "The observed post-treatment increase in striatal intrinsic activity may reflect counter-therapeutic functional adaptation to dopamine D2 receptor occupancy required for medication effects on psychosis." 01/01/2015 - "We measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in individuals at age 23 years and explored if associations between cognition and these variants differed according to the presence of familial or clinical risk for psychosis. " 10/01/2013 - "Are dopamine D2 receptors out of control in psychosis?"
4.	Alcoholism (Alcohol Abuse) 11/01/2019 - "The present study investigated alterations of DNA methylation in the dopamine D2 receptor (DRD2)-gene in patients suffering from alcohol dependence. " 02/11/2010 - "Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study." 10/10/2001 - "Alcoholism, ALDH2*2 allele and the A1 allele of the dopamine D2 receptor gene: an association study." 10/01/2000 - "Finally, we apply the proposed methods to study genetic linkage between the dopamine D2 receptor locus and alcoholism." 06/12/2000 - "Since 1990, there have been numerous reports of conflicting association studies of the Taq I A allele of the dopamine D2 receptor (DRD2) gene and alcoholism. "
5.	Inflammation (Inflammations) 12/01/2022 - "Next, we determined that the transcriptional level of dopamine D2 receptor (DRD2), which activation usually inhibits inflammation in the central nervous system (CNS), is significantly increased in the medial prefrontal cortex (mPFC) of XYS-treated mice when compared with that of vehicle-treated controls. " 06/02/2016 - "Dopamine D2 receptor (DRD2) deficiency increases renal inflammation and blood pressure in mice. " 01/15/2016 - "Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function." 05/01/2015 - "Lack or downregulation of the dopamine D2 receptor (D2R) increases the vulnerability to renal inflammation independent of blood pressure in mice. " 01/01/2015 - "In the central nervous system (CNS), A2AR are linked to dopamine D2 receptor function in striatum, but they are also important modulators of inflammation. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Dopamine (Intropin)
3.	Aripiprazole (Abilify)
4.	Adenosine (Adenocard)
5.	Bromocriptine (Parlodel)
6.	Dopamine D2 Receptors (Dopamine D2 Receptor)
7.	Cabergoline
8.	Ligands
9.	Clozapine (Clozaril)
10.	Quinpirole

Related Therapies and Procedures

1.	Therapeutics
2.	Transdermal Patch
3.	Transcranial Magnetic Stimulation
4.	Drug Therapy (Chemotherapy)
5.	Glycemic Control