|1.||Seeman, Philip: 12 articles (12/2013 - 06/2005)|
|2.||Pertovaara, Antti: 8 articles (10/2014 - 09/2002)|
|3.||Uchida, Hiroyuki: 8 articles (03/2014 - 08/2008)|
|4.||Okubo, Yoshiro: 8 articles (04/2013 - 01/2002)|
|5.||Hietala, Jarmo: 7 articles (11/2015 - 09/2002)|
|6.||Kapur, Shitij: 7 articles (10/2011 - 06/2005)|
|7.||Suhara, Tetsuya: 7 articles (07/2010 - 01/2002)|
|8.||Pollock, Bruce G: 6 articles (03/2014 - 12/2009)|
|9.||Mimura, Masaru: 6 articles (03/2014 - 04/2012)|
|10.||Suzuki, Takefumi: 6 articles (03/2014 - 04/2012)|
|1.||Schizophrenia (Dementia Praecox)
04/27/2012 - "In treating schizophrenia, it has been established that 65-80% occupancy of dopamine D2 receptors optimizes therapeutic efficacy while minimizing risks of extrapyramidal symptoms. "
01/01/2002 - "The clinical efficacy of dopamine D2 receptor antagonism on the psychotic symptoms of schizophrenia has been widely demonstrated. "
04/01/2015 - "Estimated dopamine D2 receptor occupancy and remission in schizophrenia. "
09/01/2015 - "Brexpiprazole is a new dopamine D2 receptor partial agonist that received approval for the treatment of schizophrenia and for adjunctive use for the treatment of MDD based on a clinical trial development programme that included two pivotal Phase III trials of brexpiprazole monotherapy in acute schizophrenia, and two pivotal Phase III trials of adjunctive brexpiprazole in acute MDD in patients who demonstrated inadequate response to standard antidepressant therapy. "
11/07/2014 - "Many studies have reported associations between the C957T and C939T polymorphisms in Dopamine D2 receptor (DRD2) gene and schizophrenia, but results are inconsistent. "
|2.||Parkinson Disease (Parkinson's Disease)
01/01/2014 - "Dopamine D2 receptor agonists represent a first line treatment option in young patients with signs and symptoms of idiopathic Parkinson's disease. "
01/01/2003 - "The aim of this study was to estimate the impact of stereotactic pallidal surgery on the binding potential of dopamine D2 receptors in patients with advanced Parkinson disease (PD). "
01/01/2003 - "The impact of stereotactic pallidal surgery on the dopamine D2 receptor in Parkinson disease: a positron emission tomography study."
01/01/2000 - "This study confirms an increase in dopamine D2 receptors in the putamen contralateral to the predominant symptoms, compared with the ipsilateral putamen, in early Parkinson's disease. "
10/01/1999 - "[Phase 2 clinical study of 123I-IBF, a dopamine D2 receptor imaging agent, to evaluate clinical efficacy and safety in Parkinson's disease and Parkinson syndromes]."
|3.||Migraine Disorders (Migraine)
07/01/1997 - "Therefore, the dopamine D2 receptor (DRD2) was analyzed as a candidate gene since antagonists of this receptor have been reported to be effective in the acute treatment of migraine. "
06/01/2004 - "The purpose of this study was to evaluate whether a particular genotype of the dopamine D2 receptor (DRD2) gene would affect the clinical features of migraine. "
01/01/1995 - "In migraine patients only few studies on dopamine D2 receptor binding have been reported. "
05/01/2009 - "Platelet dopamine: D2 receptor binding in patients with migraine."
06/01/2004 - "Lack of interaction between a polymorphism in the dopamine D2 receptor gene and the clinical features of migraine."
|4.||Dystonia (Limb Dystonia)
04/01/2015 - "We have observed paradoxical excitation of ChIs in the presence of dopamine D2 receptor agonists and impairment of striatal synaptic plasticity in a mouse model of DYT1 dystonia, which are improved by administration of recently developed M1 receptor antagonists. "
01/01/2011 - "Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia."
06/01/2010 - "Although the mechanism by which this genetic alteration leads to dystonia is unclear, multiple lines of clinical evidence suggest a link between dystonia and a reduced dopamine D2 receptor (D2R) availability. "
04/01/1998 - "We recently proposed that hypofunction of dopamine D2 receptor-mediated inhibition of the indirect output pathway of the basal ganglia can result in dystonia. "
10/01/1994 - "In 58 patients with Parkinsonism or dystonia striatal dopamine D2 receptors were investigated using 123I-iodobenzamide (123I-IBZM) single-photon emission computed tomography (SPECT). "
|5.||Alcoholism (Alcohol Abuse)
10/10/2001 - "Alcoholism, ALDH2*2 allele and the A1 allele of the dopamine D2 receptor gene: an association study."
10/01/2000 - "Finally, we apply the proposed methods to study genetic linkage between the dopamine D2 receptor locus and alcoholism."
06/12/2000 - "Since 1990, there have been numerous reports of conflicting association studies of the Taq I A allele of the dopamine D2 receptor (DRD2) gene and alcoholism. "
04/01/1999 - "Recent studies on the genetics of alcoholism have examined the association between alcoholism and the dopamine D2 receptor locus (DRD2); our study of Chinese Han gave negative results (Lu et al., 1996). "
09/07/1998 - "Previous studies testing the dopamine D2 receptor (DRD2) locus for association with alcoholism have produced conflicting results. "
|1.||Antipsychotic Agents (Antipsychotics)
|4.||Dopamine D2 Receptors (Dopamine D2 Receptor)
|5.||Risperidone (Risperdal Consta)
|8.||Serotonin (5 Hydroxytryptamine)
|9.||Somatostatin (Somatotropin Release-Inhibiting Factor)
|1.||Deep Brain Stimulation
|2.||Drug Therapy (Chemotherapy)