Necrobiotic Disorders (Necrobiosis)

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83 relevant articles (1 outcomes, 0 trials/studies) found for this Disease

Description: A group of disorders characterized by swelling, basophilia, and distortion of collagen bundles in the dermis.

Also Known As:

Necrobiosis; Disorder, Necrobiotic; Disorders, Necrobiotic; Necrobioses; Necrobiotic Disorder

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases

Skin Diseases: 5944

Necrobiotic Disorders: 83

Granuloma Annulare: 219

Necrobiosis Lipoidica: 118

Connective Tissue Diseases: 1633

Collagen Diseases: 536

Necrobiotic Disorders: 83

Granuloma Annulare: 219

Necrobiosis Lipoidica: 118

Related Diseases

1.	Necrosis
2.	Granuloma
3.	Granuloma Annulare
4.	Vasculitis (Vasculitides)
5.	Neoplasms (Cancer)

Experts

1.	Stephens, E: 1 article (01/2001)
2.	Gottlieb, P A: 1 article (01/2001)
3.	Robinson, J A: 1 article (01/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Necrobiotic Disorders:

1.	DNA (Deoxyribonucleic Acid)IBA 01/01/1981 - "After cessation of drug administration the abnormally high ploidy cells are eliminated - probably by necrobiosis - and the liver cells return to their normal age-dependent DNA-ploidy level" Order ALL the reference details at left...
2.	CollagenIBA 11/01/2008 - "Varying sized and shaped yeasts, capsules of varying width, capsular fragmentation and collagen necrobiosis were ultrastructurally confirmed" 11/01/2008 - "Subepithelial neutrophils and collagen necrobiosis were identified in 8 and 14 cases each, respectively" 03/01/2006 - "Histopathology reveals numerous xanthomous histiocytes and collagen necrobiosis" 05/01/2005 - "In some cases, chondrodermatitis may represent an ischemic necrobiotic disorder of collagen, potentially defining an important sign of underlying systemic disease in younger patients." 02/22/1999 - "In the area of the necrobiosis the findings of the mentioned collagens depended on the degree of necrobiotic changes (12 of 15 patients)" Order ALL the reference details at left...
3.	CholesterolIBA 02/01/1988 - "When cholesterol clefts are seen in biopsy specimens of necrobiosis, necrobiotic xanthogranuloma must be ruled out" 03/01/1976 - "Typical findings are: Rather dense distribution of relatively small foam cells within the dermis, only a few foam giant cells, great amounts of cholesterol intra- and extracellulary, and circumscribed necrobioses" 05/01/1995 - "Necrobiotic xanthogranuloma is a rare disease marked by yellowish-brown plaques with destructive growth and a tendency to ulceration, which shows a characteristic histopathological pattern of palisading granuloma with foam cells, Touton's and foreign-body giant cells, bizarre multinuclear giant cells, cholesterol clefts and marked necrobiosis of the connective tissue" 12/01/1993 - "We present the case of a patient with the classic clinical course of NPX but with many histologic features in common with NXG, namely, multinucleated lipophages, cholesterol clefts, and degeneration of collagen with associated cellular necrosis (necrobiosis)" 10/01/2000 - "Histopathologic examination showed all the major features of a necrobiotic xanthogranuloma (NX) involving the entire dermis and subcutis, including areas of necrobiosis with cholesterol clefts, granulomatous infiltrate with some bizarre giant cells, numerous Touton cells, foamy cells, lymphoid follicles with germinal centers, foci of plasma cells, and "Touton cell panniculitis." A laboratory investigation revealed only slightly increased titers of cholesterol, strong positivity of anti-Borrelia antibodies, and diffuse skeletal osteoporosis with fractures of seven vertebrae" Order ALL the reference details at left...
4.	Insulin (Novolin)FDA Link 12/01/1985 - "Pathogenetic significance of the reduction in the concentration of insulin in the erythrocytes of patients with annular granuloma and lipoid necrobiosis]" 06/01/1974 - "Treatment of lipoid necrobiosis in patients with diabetes mellitus with swine insulin]" 12/01/1983 - "HLA antigens and necrobiosis lipoidica diabeticorum--a comparison between insulin-dependent diabetics with and without necrobiosis." 12/01/1983 - "To investigate whether HLA-A, -B, -C, and -DR alloantigen frequencies are different in diabetic patients with and without necrobiosis lipoidica diabeticorum we studied 37 insulin-dependent (Type I) diabetics, 15 with and 22 without necrobiosis, and 96 normal control subjects" Order ALL the reference details at left...
5.	Ouabain (G Strophanthin)IBA 03/30/1976 - "After 8--24 h the ouabain application produces alterations in the retinal ganglion cells, that progress subsequently to necrobiosis" 12/18/1975 - "The high doses of ouabain induced an early necrobiosis of the cell bodies in the retina followed by degeneration in the nerve" Order ALL the reference details at left...
6.	MucinsIBA 10/01/2006 - "The histology shows a granulomatous infiltrate without palisading image, made up of lymphocytes, histiocytes and giant cells, with phagocytosis of elastic fibers, without necrobiosis or mucin deposit" 11/01/1979 - "The histopathology of the lesions showed many multinucleated giant cells, (often with prominent asteroid bodies), histiocytes, lymphocytes, scattered epithelioid cells, total lysis of elastic tissue, no necrobiosis, and absence of both mucin and lipid" Order ALL the reference details at left...
7.	EnzymesIBA 06/01/1976 - "The behavior of the mitochondrial GDH as well as of the lysosomal enzymes SP and BETA-GC which scarcely increased during the recirculations in the perfusate blood, however, allows the conclusion that there did not appear a severe lesion of the liver cells (necrobiosis) during several hours of perfusion" 04/01/1977 - "Our observations suggest that necrosis of histiocytes and fibroblasts with release of lysosomal enzymes is an important early event in the development of necrobiosis" Order ALL the reference details at left...
8.	Dipyridamole (Persantine)FDA LinkGeneric 12/14/1978 - "Treatment of diabetic necrobiosis with aspirin or dipyridamole." 05/04/1978 - "Treatment of diabetic necrobiosis with aspirin and dipyridamole." Order ALL the reference details at left...
9.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/14/1978 - "Treatment of diabetic necrobiosis with aspirin or dipyridamole." 05/04/1978 - "Treatment of diabetic necrobiosis with aspirin and dipyridamole." Order ALL the reference details at left...
10.	Acid PhosphataseIBA 01/01/1991 - "With larger doses (5 mg) of potassium bichromate an increase of histochemical reaction to acid phosphatase as well as forming of histopathological changes such as parenchymatous degeneration, steatosis of hepatocytes and their necrobiosis have been observed" 02/01/1983 - "Masses of histiocytes were identified infiltrating between the collagen fibers and surrounding the central necrobiosis area; the histiocytes showed a very strong diffuse acid phosphatase and nonspecific esterase activity" Order ALL the reference details at left...

Therapies and Procedures

1.	Ligation 01/01/1975 - "The necrobiosis of the central and marginal zones is reversible and the pig-skin - assuring biological ligature - plays important role in turning for better of the process" 01/01/1978 - "Disorders in the metabolism of nucleic acids were found to consist in nuclear polymorphism and in the development of regressive changes in some nuclei down to necrobiosis as well as in a decrease of the RNA content within the first 12 hours after ligation of the coronary artery" Order ALL the reference details at left...
2.	Lasers (Laser) 01/01/1991 - "Laser irradiation damage induced in these eukaryotic cells could be characterized by two development stages: a) a reversible stage with minor morphological damages (1.5 kJ/m2) and 2) an irreversible one, at higher fluences, characterized by cellular membrane damage, necrobiosis and cells detachment from the substrate (4.5 kJ/m2)" 11/01/1979 - "A definite difference was revealed in the size of zones of coagulated necrosis and necrobiosis of lingual myons situating lengthwise and across the axis of the laser ray" Order ALL the reference details at left...
3.	Cesarean Section (Caesarean Section) 01/01/1997 - "In ten patients myomectomy was performed during cesarean section delivery to prevent necrobiosis" 06/01/1953 - "Giant myoma of the ovary in necrobiosis and pregnancy; cesarean section and hysteroadnexectomy.]" Order ALL the reference details at left...
4.	Vagotomy 04/01/1984 - "Experimentally, bilateral trunkal vagotomy (BTV) generated some early acute modifications represented during the first 14 days by blood stasis, partial thrombosis, inflammatory infiltrates and necrobiosis of the gastric mucosa" Order ALL the reference details at left...
5.	Microspheres (Microsphere) 06/01/1984 - "Hepatic necrobiosis was observed in the area adjacent to the hepatic arterioles containing MMC MS, but was not observed in rats injected with placebo microspheres" Order ALL the reference details at left...

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