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U1 Small Nuclear Ribonucleoprotein

A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.
Also Known As:
Ribonucleoprotein, U1 Small Nuclear; Ribonucleoproteins, Small, U1; Small Nuclear Ribonucleoproteins, U1; U1 Small Nuclear Ribonucleoproteins; U1 snRNP
Networked: 39 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Gearing, Marla: 3 articles (12/2014 - 10/2013)
2. Hales, Chadwick M: 3 articles (12/2014 - 10/2013)
3. Seyfried, Nicholas T: 3 articles (12/2014 - 10/2013)
4. Lah, James J: 3 articles (12/2014 - 10/2013)
5. Yu, Yong: 2 articles (07/2015 - 03/2015)
6. Reed, Robin: 2 articles (07/2015 - 03/2015)
7. Levey, Allan I: 2 articles (12/2014 - 01/2014)
8. Duong, Duc M: 2 articles (12/2014 - 10/2013)
9. Diner, Ian: 2 articles (12/2014 - 10/2013)
10. Thambisetty, Madhav: 2 articles (12/2014 - 01/2014)

Related Diseases

1. Systemic Lupus Erythematosus (Libman-Sacks Disease)
2. Connective Tissue Diseases (Connective Tissue Disease)
3. Spinal Muscular Atrophy (Progressive Muscular Atrophy)
4. Mixed Connective Tissue Disease (MCTD)
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. Small Nuclear Ribonucleoproteins (snRNP)
2. Autoantibodies
3. Peptides
4. RNA (Ribonucleic Acid)
5. Immunoglobulin Fragments
6. U1 Small Nuclear Ribonucleoprotein
7. Antibodies
8. Proteins (Proteins, Gene)
9. RNA Splice Sites
10. U2 Small Nuclear Ribonucleoprotein