|1.||Krupczak, Kevin M: 1 article (11/2015)|
|2.||Wei, Jenny J: 1 article (11/2015)|
|3.||Sabatini, David M: 1 article (11/2015)|
|4.||Post, Yorick: 1 article (11/2015)|
|5.||Hughes, Nicholas W: 1 article (11/2015)|
|6.||Lander, Eric S: 1 article (11/2015)|
|7.||Wang, Tim: 1 article (11/2015)|
|8.||Birsoy, Kıvanç: 1 article (11/2015)|
|9.||Fu, Beiyuan: 1 article (11/2015)|
|10.||Yuan, Detian: 1 article (11/2015)|
01/01/2015 - "In this study, CRISPR/Cas reagents expressing one of two single-guide RNA (sgRNA) targeting the potato ACETOLACTATE SYNTHASE1 (StALS1) gene were tested for inducing targeted mutations in callus and stable events of diploid and tetraploid potato using Agrobacterium-mediated transformation with either a conventional T-DNA or a modified geminivirus T-DNA. "
03/01/2015 - "In addition, the gRNA duplex assay was adapted for monitoring foreign gene insert genetic stability during in vivo replication by analyzing the ratio of CDV N and SIV gag genomic RNA copies over the course of vector infection. "
01/01/2014 - "No synthesis priority was observed between replication (gRNA and cRNA amounts) and transcription (mRNA amounts) during NDV infection. "
01/01/2013 - "A strand-specific reverse transcription-PCR (RT-PCR) assay showed that positive-strand influenza virus mRNA and negative-strand genomic RNA (gRNA) accumulated to high levels at 8 h after infection in control Vero cells containing the empty vector. "
07/17/2014 - "This TLS not only acts like a tRNA to drive aminoacylation of the viral genomic (g)RNA, but also interacts with other structures in the 3' untranslated region of the gRNA, contains the promoter for negative-strand synthesis, and influences several infection-critical processes. "
11/27/2015 - "Using the bacterial clustered regularly interspaced short palindromic repeats (CRISPR) system, we constructed a genome-wide single-guide RNA library to screen for genes required for proliferation and survival in a human cancer cell line. "
03/03/2015 - "An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo."
01/01/2014 - "Therefore, our results suggest that HPV16-E7 gRNA guided CRISPR/Cas system might be used as a therapeutic strategy for the treatment of cervical cancer. "
|5.||Acquired Immunodeficiency Syndrome (AIDS)
08/05/2014 - "Our results suggest that Cas9/gRNA can be engineered to provide a specific, efficacious prophylactic and therapeutic approach against AIDS. "
10/01/2013 - "Together, these data further support a model for viral assembly in which the initial annealing of tRNA(Lys3) to gRNA is cytoplasmic, which in turn aids in the promotion of gRNA dimerization and its incorporation into virions. "
01/01/2015 - "HIV-1, the agent of the AIDS pandemic, is an RNA virus that reverse transcribes its RNA genome (gRNA) into DNA, shortly after its entry into cells. "
|1.||RNA (Ribonucleic Acid)
|2.||Indicators and Reagents (Reagents)
|5.||Messenger RNA (mRNA)
|7.||3' Untranslated Regions (3' UTR)
|8.||Complementary RNA (cRNA)
|9.||Transfer RNA (tRNA)
|10.||DNA-Directed RNA Polymerases (RNA Polymerase)