8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.

Also Known As:

8-OH-DPAT; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (+-)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (R)-Isomer,; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (S)-Isomer,; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (R)-Isomer,; 8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (S)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin, (+-)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin, (R)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin, (S)-Isomer; 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-

Networked: 366 relevant articles (12 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kline, Anthony E: 7 articles (05/2012 - 11/2002)
2.	Scrogin, Karie E: 5 articles (09/2012 - 03/2003)
3.	Zafonte, Ross D: 5 articles (12/2008 - 11/2002)
4.	Tiniakov, Ruslan: 4 articles (09/2012 - 11/2006)
5.	Uphouse, Lynda: 4 articles (04/2007 - 06/2002)
6.	Ohno, Yukihiro: 3 articles (06/2017 - 07/2008)
7.	Shimizu, Saki: 3 articles (06/2017 - 07/2008)
8.	Bazovkina, D V: 3 articles (01/2016 - 08/2010)
9.	Cheng, Jeffrey P: 3 articles (05/2012 - 04/2007)
10.	Nalivaiko, Eugene: 3 articles (02/2009 - 08/2005)

Related Diseases

1.	Hypothermia 07/01/1993 - "The hypothermia, but not the behavioural syndrome induced by 8-OH-DPAT was significantly greater in female compared with male rats. " 02/01/2022 - "A pretreatment administration of 8-OH-DPAT causes both tolerance (hypothermia) and behavioral sensitization (locomotor activity) in preweanling rats, whereas repeated CP-94253 treatment results in tolerance." 02/01/2022 - "On the first pretreatment day, 8-OH-DPAT, CP-94253, and DPAT + CP increased locomotion and caused hypothermia. " 11/01/2018 - "The major conclusions indicate a parallelism between the beneficial effects observed following acute 8-OH-DPAT on improving the negative consequences of aging on cognition and affect, together with the acute induction of hypothermia and hippocampal FADD regulation. " 02/16/2009 - "8-OH-DPAT caused prolongation of basal RR interval, increase in locomotion and hypothermia. "
2.	Seizures (Absence Seizure) 09/03/1993 - "Intra-HIP injection of 8-OH-DPAT (10 nmol) produced a significant elevation in the afterdischarge threshold of partial HIP seizures, with a significant reduction in the duration of focal afterdischarge. " 09/01/2005 - "Concerning KA, 8-OH-DPAT augmented the latency and reduced the frequency of wet-dog shake (WDS) and generalized seizure (GS). " 09/01/2005 - "8-OH-DPAT decreased the incidence of tonic seizures and the mortality rate induced by PTZ. " 06/01/2007 - "These results indicate that 8-OH-DPAT reduces the EEG activity associated with the KA-induced SE in the frontal cortex, but not the hippocampus, and suggest an inhibitory effect in the propagation of epileptic seizures during the KA-induced SE." 06/01/2007 - "Rats pretreated with 8-OH-DPAT presented augmented latency for wet dog shakes (71%), generalized seizures (54%) and behavioral SE (31%). "
3.	Traumatic Brain Injuries (Traumatic Brain Injury) 05/02/2012 - "8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). " 11/01/2010 - "Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury." 04/12/2007 - "The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window." 11/29/2002 - "Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats." 01/15/2013 - "Previous studies have reported a neuroprotective effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) against traumatic brain injury. "
4.	Cognitive Dysfunction 10/01/2013 - "This study suggests that 8-OH-DPAT or in general 5-HT1A/7 agonists might be useful for the treatment of TLE and also have some beneficial effects on the comorbid cognitive disorders seen in epileptic patients. " 12/01/1995 - "However, the data question the specificity of putative cognitive impairments reported in many previous studies with the 5-HT1A agonist 8-OH-DPAT."
5.	Lordosis 04/16/2007 - "These findings allow the suggestion that DOI's ability to increase PKC may be responsible for attenuation of the effects of 8-OH-DPAT on lordosis behavior." 04/16/2007 - "8-OH-DPAT inhibited lordosis behavior and DOI reduced this inhibition. " 04/16/2007 - "The PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior." 08/01/2005 - "These results suggest that 8-OH-DPAT acts on areas other than the DRN and the septum, leading to a decrease in lordosis. " 07/09/2004 - "8-OH-DPAT inhibited lordosis behavior within 15 min of the infusion and every dose of WAY100635 prevented the inhibition. "

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	Serotonin Receptors
3.	Hormones (Hormone)
4.	Muscimol
5.	zacopride
6.	Serotonin 5-HT1 Receptor Agonists
7.	Serotonin (5 Hydroxytryptamine)
8.	N-Methylaspartate (NMDA)
9.	Serotonin Agents
10.	Haloperidol (Haldol)

Related Therapies and Procedures

1.	Splenectomy
2.	Induced Hypothermia
3.	Injections
4.	Intravenous Injections
5.	Denervation