Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

Also Known As:

Networked: 781 relevant articles (16 outcomes, 87 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Delivoria-Papadopoulos, Maria: 8 articles (08/2011 - 02/2005)
2.	Xiao, Xiangshu: 7 articles (03/2022 - 04/2012)
3.	Li, Bingbing X: 6 articles (03/2022 - 04/2012)
4.	Zhang, Lin: 5 articles (05/2022 - 12/2009)
5.	Zhang, Li-Cai: 5 articles (11/2015 - 04/2005)
6.	Klemm, Dwight J: 5 articles (04/2014 - 07/2006)
7.	Ashraf, Qazi M: 5 articles (08/2011 - 12/2006)
8.	Ichiki, Toshihiro: 5 articles (06/2009 - 05/2002)
9.	Zhao, Yan: 4 articles (05/2022 - 04/2006)
10.	Xie, Fuchun: 4 articles (10/2020 - 04/2012)

Related Diseases

1.	Cognitive Dysfunction 01/01/2019 - "We investigated the role of cAMP response element binding protein (CREB) and its downstream signaling pathways in the pathogenesis of cognitive impairment in mice with TLE. " 01/01/2015 - "The cAMP response element binding protein (CREB) plays an important role in the mechanism of cognitive impairment and is also pivotal in the switch from short-term to long-term memory. " 09/13/2010 - "The cAMP-response element binding protein (CREB) is one of the cellular molecules that have been strongly implicated in the synaptic plasticity deficits occurring in age-related memory and cognitive impairment. " 09/01/2019 - "The study was designed to investigate the predictive value of phosphorylated CAMP response element binding protein (p-CREB) level in peripheral blood on secondary cognitive impairment in patients with mild-to-moderate craniocerebral trauma. " 02/01/2023 - "Schizophrenia (SZ) is associated with cognitive impairment, and it is known that the activity of cAMP response element binding protein (CREB) decreases in the brain of SZ patients. "
2.	Hypoxia (Hypoxemia) 05/30/2007 - "The aim of the present study was to understand the importance of neuronal nuclear Ca(2+) in the role of CaM KIV activation and CREB protein phosphorylation associated with hypoxia. " 01/01/2002 - "Previous studies have shown that hypoxia results in increased phosphorylation of CREB protein that mediates gene expression including that of the pro-apoptotic gene bax. " 11/01/2018 - "A learning stimulus increased the nuclear translocation of phosphorylated cAMP response element binding protein (p-CREB), an effect that was greatly inhibited by hypoxia. " 02/01/2017 - "These viruses express small hairpin RNAs (shRNAs) targeting cyclic AMP-response-element binding protein (CREB), hypoxia-inducible factors 1 (HIF)-1 or HIF-2 individually or all three together (X3). " 02/01/2008 - "By using this system, the transcriptional activator cyclic-AMP-response-element-binding protein (CREB) was phosphorylated at Ser-133 and the hypoxia-inducible factor-1alpha (HIF-1alpha) was hydroxylated at Asn-803 in E. "
3.	AIDS-Related Complex (ARC) 03/05/2010 - "In this study we tested the hypothesis that altered cAMP response element binding (CREB) protein induction and activity-regulated cytoskeletal-associated gene (Arc) expression may underlie the suppression of hippocampal neurogenesis and memory impairment associated with early sensorimotor deprivation. " 08/01/2015 - "CREB (cAMP-response element-binding protein) signaling, Arc and brain-derived neurotrophic factor, which play important roles in synaptic plasticity and adaptive cellular stress responses, were up-regulated in response to DNP, and DNP-treated mice exhibited improved performance in a test of learning and memory. " 01/05/2016 - "Furthermore, we analyzed levels of oxidative stress, as well as cyclic adenosine 3',5'-monophosphate response element-binding (CREB) protein phosphorylation and immediate early gene (IEG, including Arc, c-fos, and Egr1) expression levels using Western blot analysis. " 04/23/2014 - "Arc is regulated by the transcription factor cAMP response element binding protein, which is upregulated with and necessary for fear extinction. " 01/01/2013 - "Both the activity of neurons, which was evaluated by immunohistochemical detection for phosphorylated-cAMP response element binding protein (pCREB), and NPY mRNA levels in the caudal ARC were higher at 0.5 hr after lights on than the other two time points, while pCREB-positive cell numbers in the rostral ARC remained unchanged throughout the experimental period. "
4.	Neoplasms (Cancer) 08/01/2003 - "This study therefore aimed to analyze the status of the CREB protein in various types of human adrenocortical tumors and normal fetal adrenal cortex. " 10/21/2023 - "Expression of PRKACA, PRKACB, and phosphorylated cAMP response element-binding protein was upregulated in neoplasms with PRKACA/B fusion genes (P < .05). " 08/11/2022 - "Application of Degradation of Cyclic-AMP Response Element Binding Protein for the Potential Treatment of Cancer." 12/20/2021 - "The cyclic AMP response element-binding protein (CREB) is overexpressed both in haematological malignancies and solid tumours and its expression and function are modulated following irradiation. " 08/01/2021 - "Intracranial myxoid mesenchymal tumor (IMMT) is a recently described, extremely rare group of neoplasms characterized by fusions between the female-expressed transcript (FET) family genes and the cAMP response element-binding protein (CREB) family genes. "
5.	Hepatocellular Carcinoma (Hepatoma) 10/04/2013 - "We show for the first time that potent microRNA-433 (miR-433) inhibition of expression of the cAMP response element-binding protein CREB1 represses hepatocellular carcinoma (HCC) cell migration. " 07/01/1997 - "Further analysis by cross-linking, super shift, and competition experiments was performed with liver cell nuclear extracts, hepatoma cell nuclear extracts, or recombinant CREB protein. " 10/23/1996 - "However, treatment of rat hepatoma cells with cAMP did result in accumulation of CREB protein. " 01/15/1991 - "We could not find the Mr 47,000 CREB protein in the 5123tc and 5123D hepatomas. " 03/28/2003 - "To study the mechanism(s) by which persistent ERK phosphorylation might induce cell growth inhibition, we used Cpd 5 as a tool to examine its effects on the activity of CREB (cAMP response element-binding protein) transcription factor in Hep3B human hepatoma cells. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	Transcription Factors (Transcription Factor)
3.	Proteins (Proteins, Gene)
4.	Messenger RNA (mRNA)
5.	Histones (Histone)
6.	CREB-Binding Protein
7.	Elements
8.	DNA (Deoxyribonucleic Acid)
9.	Amyloid beta-Peptides
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Electroacupuncture
2.	Ligation
3.	Therapeutics
4.	Spinal Injections
5.	Cardiopulmonary Resuscitation (CPR)