Viral Nonstructural Proteins

Proteins encoded by a VIRAL GENOME that are not structural components of VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.

Also Known As:

NS Proteins, Viral; Viral NS Proteins; Viral Non-Structural Proteins; Viral Nonstructural Protein; Viral Nonstructural Proteins NS1; Viral Nonstructural Proteins NS2; Nonstructural Protein, Viral; Viral Non Structural Proteins; Nonstructural Proteins, Viral

Networked: 70 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - Viral Nonstructural Proteins: 70

Experts

1.	Chen, Hongyan: 4 articles (01/2017 - 04/2014)
2.	Wei, Taiyun: 4 articles (01/2017 - 04/2014)
3.	Jia, Dongsheng: 3 articles (01/2017 - 04/2014)
4.	Mao, Qianzhuo: 3 articles (01/2017 - 04/2014)
5.	Dechtawewat, Thanyaporn: 2 articles (01/2021 - 01/2020)
6.	Limjindaporn, Thawornchai: 2 articles (01/2021 - 01/2020)
7.	Malasit, Prida: 2 articles (01/2021 - 01/2020)
8.	Noisakran, Sansanee: 2 articles (01/2021 - 01/2020)
9.	Puttikhunt, Chunya: 2 articles (01/2021 - 01/2020)
10.	Songprakhon, Pucharee: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Virus Diseases (Viral Diseases) 12/02/2015 - "Viral nonstructural protein Pns12 forms viroplasm-like inclusions in the absence of viral infection, suggesting that the viroplasm matrix is basically composed of Pns12. " 04/01/2014 - "Within 24 h of viral infection of cultured cells, the viroplasm had formed and contained the viral nonstructural proteins Pns6 and Pns10, known to be constituents of viroplasm. " 04/01/2002 - "Furthermore, simple transient expression of the viral nonstructural proteins is insufficient to induce this nuclear reorganization, suggesting that this event is induced specifically by a step in the viral infection process." 01/01/2017 - "An important player in subverting the host response to HCV infection is the viral nonstructural protein NS5A, which, in addition to its role in replication and assembly, targets several pathways involved in the cellular response to viral infection. " 12/01/2012 - "Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. "
2.	Infections 01/01/2018 - "In this study, we provide evidence that porcine reproductive and respiratory syndrome virus (PRRSV) infection induces host translation shutoff and that the viral nonstructural protein nsp2 is associated with this process. " 01/01/2023 - "Furthermore, we demonstrated that HDAC6 interacted with viral nonstructural protein 8 (nsp8) in the context of PDCoV infection, resulting in its proteasomal degradation, which was dependent on the deacetylation activity of HDAC6. " 01/01/2021 - "In contrast, infection with FMD virus leads to virus replication and additional antibody responses to viral nonstructural proteins (NSP). " 01/01/2021 - "Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection." 11/15/2019 - "Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection."
3.	Alphavirus Infections 12/01/2012 - "Here, we report that early in Semliki Forest virus infection, the C-terminal domain of the viral nonstructural protein 3 (nsP3) forms a complex with Ras-GAP SH3-domain-binding protein (G3BP) and sequesters it into viral RNA replication complexes in a manner that inhibits the formation of SGs on viral mRNAs. " 10/10/2007 - "Our studies demonstrated the following: (i) the host protein hnRNP K is enriched in cytoplasmic membrane fractions following Sindbis virus infection, (ii) viral nonstructural proteins co-immunoprecipitate with hnRNP K, (iii) nsP2 and hnRNP K co-localize in the cytoplasm of Sindbis virus infected cells, (iv) Sindbis virus subgenomic mRNA, but not genomic RNA co-immunoprecipitates with hnRNP K, (v) viral RNA does not appear to be required for the interaction of hnRNP K with the nonstructural proteins. "
4.	Aneuploidy (Aneuploid) 10/24/2008 - "Studies have demonstrated the roles of viral nonstructural protein 5A (NS5A) in the induction of chromosome aneuploidy, but the molecular mechanisms are not clear. "
5.	Hepatitis C 01/01/2020 - "The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts." 01/01/2018 - "The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts." 06/01/2012 - "A cell-permeable hairpin peptide inhibits hepatitis C viral nonstructural protein 5A-mediated translation and virus production." 04/01/2016 - "The human molecular chaperones heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70) bind to the hepatitis C viral nonstructural protein 5A (NS5A) and regulate its activity. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Viral RNA
3.	RNA (Ribonucleic Acid)
4.	Messenger RNA (mRNA)
5.	Subgenomic RNA
6.	Heterogeneous-Nuclear Ribonucleoprotein K
7.	Enzymes
8.	Cholesterol
9.	Antibodies
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics