Photosensitizing Agents (Photosensitizers)

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.

Also Known As:

Networked: 5933 relevant articles (433 outcomes, 709 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hamblin, Michael R: 39 articles (04/2022 - 01/2002)
2.	Hasan, Tayyaba: 37 articles (08/2022 - 01/2002)
3.	Abrahamse, Heidi: 36 articles (01/2022 - 04/2006)
4.	Pandey, Ravindra K: 33 articles (09/2022 - 04/2003)
5.	Na, Kun: 32 articles (06/2022 - 07/2010)
6.	Berg, Kristian: 32 articles (10/2021 - 03/2002)
7.	Frochot, Céline: 29 articles (09/2022 - 04/2005)
8.	Tang, Ben Zhong: 28 articles (05/2022 - 02/2015)
9.	Liu, Bin: 24 articles (01/2022 - 09/2014)
10.	Olivo, Malini: 24 articles (02/2015 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "In this paper, our studies centers on synthesizing a highly soluble photosensitizing agent with improved effectiveness on detecting cancer cells." 04/13/2016 - "In vitro tests performed on HepG2 cancer cells confirm that the cell suppression rate was improved by more than 40% in the presence of light in the presence of an extremely low energy density (12 J/cm(2)) with very low concentration of 5.4 μM photosensitizer. " 07/14/2018 - "This nanovesicle exhibited reduced aggregation of PPhA photosensitizers and high targeting ability towards cancer cells, thereby leading to excellent therapeutic efficacy under red light." 03/10/2023 - "Despite the great progress in the development of new photosensitizers with improved efficacy, the PS's photosensitivity, high hydrophobicity, and tumor target avidity still represent the main challenges. " 01/01/2022 - "Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility and low tumor accumulation. "
2.	Hypoxia (Hypoxemia) 08/21/2020 - "Self-Assembly of Mitochondria-Targeted Photosensitizer to Increase Photostability and Photodynamic Therapeutic Efficacy in Hypoxia." 10/19/2022 - "Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare Type-I PSs is of great importance, but remains a challenge. " 03/02/2022 - "To address this problem, we developed hypoxia-assisted NP-co-encapsulating Ce6 (photosensitizer) and YC-1 (HIF-1α inhibitor) as a self-rectifiable nanoinhibitor for synergistic antitumor treatment. " 11/12/2020 - "However, hypoxia in the tumor microenvironment (TME) and low penetrability of photosensitizers further limit their clinical application. " 09/28/2020 - "The photosensitizer exhibited an unprecedented PI > 90 (EC50 = 0.651 μM) in hypoxia (1% O2) with visible and green light, and a PI > 70 with red light. "
3.	Carcinoma (Carcinomatosis) 03/01/1990 - "Verdins have been shown to be effective photosensitizers in a urothelial carcinoma model in rats. " 09/01/2017 - "In the present study, besides confirm the high cytotoxicity in another cell line, we have further investigated the cell death mechanisms caused by CHL-T as a photosensitizer in laryngeal carcinoma cells. " 02/25/2016 - "The subcellular localization of a photosensitizer is critical for efficient photoinduced cell death, in this way, colocalization studies were performed within HeLa cell line (human cervical carcinoma) through confocal microscopy. " 03/01/2009 - "For in vivo studies, Swiss athymic mice were grafted with human lung carcinoma of the line A549 15 days before intravenous photosensitizer injection. " 01/01/2008 - "Characterization of a new photosensitizer (13(2)-hydroxy- bacteriopheophorbide-a methylester) for future treatment of ovarian carcinoma (an experimental study)."
4.	Breast Neoplasms (Breast Cancer) 11/15/2023 - "The photosensitizers KDP1 and KDP2 were found to be localized in the mitochondria with excellent photocytotoxicity of up to 18.7 nM in MDA-MB-231 breast cancer cells. " 11/30/2022 - "Modification of Ce6@sAuNRs with THA resulted in efficient internalization of the nanocomposite into MCF-7/ADR multidrug-resistant (MDR) breast cancer cells (CD44+), thereby significantly enhancing the intracellular accumulation of the photosensitizer Ce6. " 01/01/2021 - "TTRE, a photosensitizer molecule, has excellent biofluorescence imaging performance and effective antitumor properties for breast cancer. " 01/01/2020 - "Our result proved that GaPcCl is an effective photosensitizer in MCF-7 human breast cancer cell line. " 01/01/2019 - "Cytotoxicity assays demonstrated the cytotoxic activity of all photosensitizers for prostate and breast tumor cell lines. "
5.	Melanoma (Melanoma, Malignant) 12/10/2020 - "Photosensitizer-stabilized self-assembling nanoparticles potentiate chemo/photodynamic efficacy of patient-derived melanoma." 06/01/2015 - "In this work, we report on the study of the BCD photocytotoxicity toward melanoma and normal cells in comparison with that of commercial photosensitizer Photogem®. " 04/01/2014 - "In-vitro studies have indicated that this photosensitizer is toxic to melanoma cells when irradiated with low energy light; however, it is nontoxic to normal cells under similar conditions. " 09/01/2012 - "Study of efficiency of the modular nanotransporter for targeted delivery of photosensitizers to melanoma cell nuclei in vivo." 11/21/2020 - "Towards the development of specialized photosensitizers (PSs) for treating pigmented melanomas, nine new near-infrared (NIR) absorbing PSs based on a Ru(ii) tris-heteroleptic scaffold [Ru(NNN)(NN)(L)]Cl n , were explored. "

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	phytochlorin
3.	Oxygen (Dioxygen)
4.	Photosensitizing Agents (Photosensitizers)
5.	Porphyrins
6.	Acids
7.	Dihematoporphyrin Ether (Porfimer Sodium)
8.	Singlet Oxygen
9.	temoporfin
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Therapeutics
3.	Lasers (Laser)
4.	Phototherapy (Light Therapy)
5.	Photothermal Therapy