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Polymyositis

Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
Also Known As:
Polymyositis Ossificans; Polymyositis, Idiopathic; Idiopathic Polymyositides; Idiopathic Polymyositis; Multiple Myositis; Myositides, Multiple; Ossificans, Polymyositis; Polymyositides; Polymyositides, Idiopathic; Myositis, Multiple
Networked: 1539 relevant articles (91 outcomes, 109 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Dermatomyositis (Dermatopolymyositis)
2. Interstitial Lung Diseases (Interstitial Lung Disease)
3. Muscular Diseases (Myopathy)
4. Myasthenia Gravis
5. Myositis (Idiopathic Inflammatory Myopathies)

Experts

1. Lundberg, Ingrid E: 17 articles (11/2014 - 04/2002)
2. Miller, Frederick W: 15 articles (09/2014 - 08/2003)
3. Rider, Lisa G: 13 articles (09/2014 - 11/2006)
4. Alexanderson, Helene: 11 articles (11/2014 - 05/2004)
5. Lundberg, I E: 8 articles (10/2015 - 10/2001)
6. Miyasaka, Nobuyuki: 8 articles (07/2015 - 12/2003)
7. Mimori, Tsuneyo: 8 articles (01/2015 - 09/2004)
8. Oddis, Chester V: 8 articles (09/2014 - 12/2002)
9. Targoff, Ira N: 8 articles (05/2014 - 10/2002)
10. Shinjo, Samuel Katsuyuki: 7 articles (03/2015 - 02/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Polymyositis:
1. Cyclosporine (Ciclosporin)FDA LinkGeneric
2. Immunoglobulins (Immunoglobulin)IBA
3. Adrenal Cortex Hormones (Corticosteroids)IBA
4. Tacrolimus (Prograf)FDA LinkGeneric
5. Intravenous Immunoglobulins (IVIG)FDA Link
6. Prednisolone (Predate)FDA LinkGeneric
7. Azathioprine (Imuran)FDA LinkGeneric
8. SteroidsIBA
9. Methotrexate (Mexate)FDA LinkGeneric
10. I-antigenIBA

Therapies and Procedures

1. Resistance Training
2. Aftercare (After-Treatment)
3. Plasma Exchange
4. Drug Therapy (Chemotherapy)
5. Immunotherapy