Goserelin (Zoladex)

A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.

Also Known As:

Zoladex; Goserelin Acetate; ICI-118630; Acetate, Goserelin; ICI 118630; ICI118630; Luteinizing hormone-releasing factor (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-10-deglycinamide-, 2-(aminocarbonyl)hydrazide

Networked: 757 relevant articles (88 outcomes, 211 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gnant, Michael: 8 articles (11/2020 - 12/2002)
2.	Jakesz, Raimund: 6 articles (07/2011 - 12/2002)
3.	Mlineritsch, Brigitte: 6 articles (07/2011 - 12/2002)
4.	Greil, Richard: 5 articles (11/2020 - 09/2008)
5.	Gelber, Richard D: 5 articles (01/2019 - 12/2003)
6.	Hanks, Gerald E: 5 articles (01/2017 - 12/2007)
7.	Loibl, Sibylle: 5 articles (01/2017 - 08/2005)
8.	Sandler, Howard M: 5 articles (01/2017 - 12/2007)
9.	Noguchi, Shinzaburo: 5 articles (09/2016 - 01/2003)
10.	Dubsky, Peter: 5 articles (09/2012 - 09/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 04/01/1995 - "A case report is presented of a patient with premenopausal recurrent breast cancer in whom good results were obtained by concomitant administration of Zoladex and CPA." 10/01/2016 - "Goserelin, a form of medical ovarian suppression, is an effective treatment for pre-menopausal women with breast cancer (PMBC). " 10/01/2011 - "For pre/perimenopausal women with lymph-node-negative ER-positive breast cancer, CMF followed by goserelin improved DFS in comparison with either modality alone. " 06/10/2011 - "We aimed to test the efficacy of ovarian function preservation with the LHRHa goserelin in patients with breast cancer. " 10/01/2009 - "A total of 285 premenopausal breast cancer patients, in a randomized adjuvant trial (Zoladex in premenopausal patients (ZIPP)), were assigned to a study on ovarian function. "
2.	Prostatic Neoplasms (Prostate Cancer) 08/01/2005 - "RTOG study shows improved survival for prostate cancer patients given adjuvant goserelin." 01/01/1995 - "A randomised trial comparing the safety and efficacy of the Zoladex 10.8-mg depot, administered every 12 weeks, to that of the Zoladex 3.6-mg depot, administered every 4 weeks, in patients with advanced prostate cancer. " 11/01/1988 - "The results indicated that Zoladex in a once monthly regimen may be of great advantage to elderly patients with prostatic cancer, and allow an improved patient compliance: Zoladex may not only produce clinical remission but also improve the quality of life." 06/01/2011 - "Fourty-seven patients with prostate cancer receiving hormonal manipulation by goserelin acetate were enrolled in this study. " 12/15/2007 - "Between 1987 and 1992, 945 eligible men with locally advanced prostate cancer were enrolled in a phase 3 trial (RTOG 85-31) and randomized to RT and immediate goserelin or RT alone followed by goserelin at recurrence. "
3.	Endometriosis 08/01/2012 - "To evaluate the short-term and long-term efficacy of conservative laparoscopic surgery combine with goserelin in treatment of severe ovarian endometriosis. " 08/01/2012 - "[Efficacy of conservative laparoscopic surgery combined with goserelin in treatment of 206 patients with severe ovarian endometriosis at short-term and long-term follow-up]." 08/01/2015 - "Reduced endometrial staining of LIF, LIFR and gp130, unaffected by surgery and goserelin, was seen in endometriosis patients without a recorded pregnancy during the study. " 05/01/1995 - "ZOLADEX Endometriosis Study Group." 08/01/1993 - "The Zoladex Endometriosis Study Group."
4.	Pain (Aches) 01/01/1990 - "Although there were no significant differences in the overall subjective response to both treatments, a faster improvement, with respect to pain and performance status was noted in the Zoladex plus CPA group (8 weeks) compared to Zoladex alone (12 weeks). " 01/01/2014 - "Fifteen-second skin icing using a frozen gel pack is effective for reducing goserelin injection pain." 10/01/2010 - "Icing at the injection site of goserelin acetate is a safe and effective method to reduce injection pain. " 01/01/2014 - "The efficacy of skin icing to reduce the pain of goserelin injection has been reported. " 01/01/2018 - "At six months' follow-up, there was no clear evidence of a difference between the COCP and goserelin groups for reporting complete absence of pain as measured by the visual analogue scale (risk ratio (RR) 0.36, 95% CI 0.02 to 8.43; 1 RCT, 50 women; very low quality evidence) or the verbal rating scale (RR 1.00, 95% CI 0.93 to 1.08; 1 RCT, 49 women; low quality evidence). "
5.	Neoplasms (Cancer) 10/01/2011 - "Patients with ER-negative tumors whose treatment included CMF had similar DFS (12-year DFS CMF = 67%; 12-year DFS CMF→ goserelin = 69%) compared with goserelin alone (12-year DFS = 61%, P= NS). " 12/17/2003 - "Patients with ER-negative tumors achieved better disease-free survival if they received CMF (5-year DFS for CMF = 84%, 95% confidence interval [CI] = 77% to 91%; 5-year DFS for CMF --> goserelin = 88%, 95% CI = 82% to 94%) than if they received goserelin alone (5-year DFS = 73%, 95% CI = 64% to 81%). " 03/01/1997 - "However, in patients with centrally reviewed tumors with a Gleason score of 8 to 10, the difference in actuarial 5-year survival (66% on the adjuvant goserelin arm v 55% on the observation arm) reaches statistical significance (P = .03). " 02/01/1987 - "No specific correlation among serum Zoladex concentrations, endocrinologic parameters, and tumor response rates were found. " 01/01/1987 - "However, in tumors from rats treated with Zoladex every 4 and 6 weeks progressive increasing signs of restoration of normal elements, comparable to non-treated tumors were observed. "

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Goserelin (Zoladex)
3.	Tamoxifen
4.	Hormones (Hormone)
5.	bicalutamide (Casodex)
6.	Anastrozole (Arimidex)
7.	Androgens
8.	Estradiol (Delestrogen)
9.	acetyl- 2- naphthylalanyl- 3- chlorophenylalanyl- 1- oxohexadecyl- seryl- 4- aminophenylalanyl(hydroorotyl)- 4- aminophenylalanyl(carbamoyl)- leucyl- ILys- prolyl- alaninamide
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Orchiectomy (Orchidectomy)
4.	Radiotherapy
5.	Castration