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Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)

A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
Also Known As:
Progressive External Ophthalmoplegia; CPEO; Ocular Muscular Dystrophy; Ophthalmoplegia, Chronic Progressive External; Graefe's Disease; Ocular Myopathy of Von Graefe-Fuchs; Ophthalmoplegia, Progressive External; Disease, Graefe; Dystrophies, Ocular Muscular; Dystrophy, Ocular Muscular; External Ophthalmoplegia, Progressive; External Ophthalmoplegias, Progressive; Graefes Disease; Mitochondrial Ocular Myopathies; Muscular Dystrophies, Ocular; Muscular Dystrophy, Ocular; Myopathies, Mitochondrial Ocular; Myopathy, Mitochondrial Ocular; Ocular Muscular Dystrophies; Ocular Myopathies, Mitochondrial; Ocular Myopathy of Von Graefe Fuchs; Ocular Myopathy, Mitochondrial; Ophthalmoplegias, Progressive External; Progressive External Ophthalmoplegias; Graefe Disease; Mitochondrial Ocular Myopathy
Networked: 446 relevant articles (5 outcomes, 43 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)
2. Kearns-Sayre Syndrome
3. Mitochondrial Myopathies (Mitochondrial Myopathy)
4. Retinitis Pigmentosa (Pigmentary Retinopathy)
5. Ataxia (Dyssynergia)

Experts

1. Taylor, Robert W: 17 articles (06/2015 - 09/2003)
2. Zeviani, Massimo: 15 articles (07/2015 - 08/2002)
3. Turnbull, Douglass M: 12 articles (01/2015 - 09/2003)
4. Copeland, William C: 12 articles (09/2014 - 05/2002)
5. Suomalainen, Anu: 11 articles (01/2012 - 01/2004)
6. Chinnery, Patrick F: 10 articles (01/2015 - 12/2003)
7. DiMauro, Salvatore: 9 articles (11/2012 - 09/2002)
8. Moggio, Maurizio: 8 articles (07/2015 - 08/2002)
9. Ronchi, Dario: 7 articles (07/2015 - 05/2010)
10. Sciacco, Monica: 7 articles (05/2015 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Progressive External Ophthalmoplegia:
1. Mitochondrial DNA (mtDNA)IBA
2. coenzyme Q10 (CoQ10)IBA
3. Carnitine (L-Carnitine)FDA LinkGeneric
4. UbiquinoneIBA
5. Neuropathy ataxia and retinis pigmentosaIBA
6. Electron Transport Complex IV (Cytochrome c Oxidase)IBA
7. DNA (Deoxyribonucleic Acid)IBA
8. Ile Transfer RNAIBA
9. Tyr Transfer RNAIBA
10. PhosphorusIBA

Therapies and Procedures

1. Mechanical Ventilators (Ventilator)
2. Ligation
3. Lasers (Laser)
4. Transplants (Transplant)
5. Heart Transplantation (Grafting, Heart)