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Complement Factor I (C3b Inactivator)

A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
Also Known As:
C3b Inactivator; C3b-C4b Inactivator; C4b-C3b-INA; C4bC3bINA; Complement 3b-Complement 4b Inactivator; Complement C4b-C3b Inactivator; C3b C4b Inactivator; C4b C3b INA; C4b-C3b Inactivator, Complement; Complement 3b Complement 4b Inactivator; Complement C4b C3b Inactivator; Inactivator, C3b; Inactivator, C3b-C4b; Inactivator, Complement C4b-C3b
Networked: 54 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kavanagh, David: 3 articles (07/2015 - 01/2008)
2. Atkinson, John P: 3 articles (07/2015 - 01/2008)
3. Triebwasser, Michael: 2 articles (07/2015 - 03/2011)
4. Blom, Anna M: 2 articles (04/2015 - 01/2008)
5. Okroj, Marcin: 2 articles (04/2015 - 01/2008)
6. Cree, Angela J: 2 articles (01/2014 - 01/2010)
7. Gibson, Jane: 2 articles (01/2014 - 01/2010)
8. Ennis, Sarah: 2 articles (01/2014 - 01/2010)
9. Lotery, Andrew J: 2 articles (01/2014 - 01/2010)
10. Liszewski, M Kathryn: 2 articles (03/2011 - 01/2008)

Related Diseases

1. Geographic Atrophy
2. Macular Degeneration (Age-Related Maculopathy)
3. Infection
4. Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
5. Glomerulonephritis

Related Drugs and Biologics

1. chemotactic factor inactivator
2. Complement System Proteins (Complement)
3. Complement Factor B (Factor B)
4. Complement Factor H (Factor H)
5. Properdin
6. Antigen-Antibody Complex (Immune Complex)
7. Proteins (Proteins, Gene)
8. Inulin
9. Immunoglobulins (Immunoglobulin)
10. Fibrinogen (Factor I)