Complement Factor H (Factor H)

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

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Networked: 1229 relevant articles (24 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zipfel, Peter F: 60 articles (11/2021 - 02/2001)
2.	Skerka, Christine: 36 articles (11/2021 - 02/2001)
3.	Pickering, Matthew C: 30 articles (01/2021 - 08/2002)
4.	Frémeaux-Bacchi, Véronique: 29 articles (01/2019 - 03/2004)
5.	Kavanagh, David: 24 articles (04/2022 - 07/2005)
6.	Noris, Marina: 22 articles (10/2019 - 02/2001)
7.	Remuzzi, Giuseppe: 22 articles (10/2019 - 02/2001)
8.	Dragon-Durey, Marie-Agnès: 19 articles (01/2021 - 03/2004)
9.	Józsi, Mihály: 18 articles (01/2021 - 01/2006)
10.	Goodship, Timothy H J: 18 articles (01/2016 - 10/2003)

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy) 01/01/2019 - "To evaluate the efficacy of using a CRISPR/Cas-mediated strategy to correct a common high-risk allele that is associated with age-related macular degeneration (AMD; rs1061170; NM_000186.3:c.1204T>C; NP_000177.2:p.His402Tyr) in the complement factor H (CFH) gene. " 11/14/2006 - "Polymorphisms in the complement factor H gene (CFH) are associated with a significantly increased risk for, or protection against, the development of age-related macular degeneration (AMD). " 09/01/2007 - "Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration." 01/01/2022 - "To determine the association between rare genetic variants in complement factor H (CFH) and phenotypic features in age-related macular degeneration (AMD) patients from the Coimbra Eye Study (CES). " 03/01/2017 - "English-language studies assessing AREDS supplement response in patients with AMD in relation to complement factor H gene ( CFH) and age-related maculopathy susceptibility 2 gene ( ARMS2) risk alleles were evaluated. "
2.	Inflammation (Inflammations) 06/01/2015 - "2-Hydroxypropyl-β-cyclodextrin is as effective in reducing Aβ and inflammation in the complement factor H knockout (Cfh(-/-)) mouse that shows advanced ageing and has been proposed as an AMD model. " 01/01/2021 - "This study used RPE generated from induced pluripotent stem cells (iPSC-RPE), which were derived from human donors with or without AMD and genotyped for the complement factor H (CFH) AMD high-risk allele (rs1061170, Y402H) to investigate whether donor disease state or genotype had a detrimental effect on mitochondrial function and inflammation. " 11/23/2023 - "To explore the role and underlying mechanism of Complement Factor H (CFH) in the peripheral and joint inflammation of RA patients. " 01/01/2021 - "Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells." 01/01/2021 - "The increased C3, C4 and Factor-H during the second trimester of pregnancy in GDM are not independently associated with GDM; inflammation and high BMI may be responsible for their elevation. "
3.	Atypical Hemolytic Uremic Syndrome 08/01/2022 - "Correction: Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis." 06/01/2022 - "In addition, the patient was found to be heterozygous for the complement factor H (CFH) H3 haplotype (involving the rare alleles of c.-331C>T, Q672Q and E936D polymorphisms) reported as a risk factor of atypical hemolytic uremic syndrome. " 01/01/2022 - "Anti-factor H antibody and its role in atypical hemolytic uremic syndrome." 01/01/2022 - "Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis." 10/26/2021 - "Anti-Factor H Antibody-Associated Atypical Hemolytic Uremic Syndrome: A Case Report."
4.	Lupus Nephritis 01/01/2021 - "This study aimed to explore the associations between the complement factor H (CFH) rs6677604 and clinico-pathological characteristics of lupus nephritis. " 10/01/2016 - "Our previous study showed that plasma levels of factor H (FH) were significantly decreased in patients with lupus nephritis and reflected lupus nephritis activity. " 01/01/2019 - "A deficiency of complement factor H may lead to excessive consumption of C3 and an increase in C3b deposition, which are important pathological characteristics of lupus nephritis. " 10/01/2016 - "The dysfunctions of complement factor H in lupus nephritis." 12/01/2012 - "Serum complement factor H is associated with clinical and pathological activities of patients with lupus nephritis."
5.	Hemolytic-Uremic Syndrome 09/01/2003 - "Successful (?) therapy of hemolytic-uremic syndrome with factor H abnormality." 02/01/2001 - "Several recent studies have established an association between abnormalities of complement factor H (FH) and the development of hemolytic uremic syndrome (HUS). " 12/01/2021 - "Anti-Compliment Factor H antibody hemolytic uremic syndrome (AFH-HUS) is a common cause of paediatric atypical HUS in India. " 01/01/2017 - "Hemolytic uremic syndrome with multiple organ involvement secondary to complement factor H p.Arg1215X mutation." 08/01/2014 - "Outcomes of renal transplant in patients with anti-complement factor H antibody-associated hemolytic uremic syndrome."

Related Drugs and Biologics

1.	Complement System Proteins (Complement)
2.	Proteins (Proteins, Gene)
3.	Autoantibodies
4.	eculizumab
5.	Immunoglobulin G (IgG)
6.	Biomarkers (Surrogate Marker)
7.	Complement Inactivating Agents
8.	Complement C3b (C3bi)
9.	CD55 Antigens (Decay Accelerating Factor)
10.	Recombinant Proteins

Related Therapies and Procedures

1.	Therapeutics
2.	Plasma Exchange
3.	Aftercare (After-Treatment)
4.	Lasers (Laser)
5.	Kidney Transplantation