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Complement Factor H (Factor H)

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
Also Known As:
Factor H; Factor H, Complement; Complement factor H
Networked: 708 relevant articles (12 outcomes, 64 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zipfel, Peter F: 34 articles (11/2014 - 03/2002)
2. Skerka, Christine: 20 articles (11/2014 - 02/2007)
3. Frémeaux-Bacchi, Véronique: 16 articles (01/2016 - 03/2004)
4. Pickering, Matthew C: 15 articles (04/2014 - 08/2002)
5. Klein, Barbara E K: 13 articles (02/2015 - 09/2007)
6. Klein, Ronald: 13 articles (02/2015 - 09/2007)
7. Meri, Seppo: 13 articles (02/2014 - 10/2002)
8. Iyengar, Sudha K: 11 articles (11/2015 - 09/2007)
9. Dragon-Durey, Marie-Agnès: 11 articles (06/2015 - 03/2004)
10. Marconi, Richard T: 11 articles (04/2012 - 06/2003)

Related Diseases

1. Macular Degeneration (Age-Related Maculopathy)
2. Inflammation
3. Hemolytic-Uremic Syndrome
4. Lung Neoplasms (Lung Cancer)
5. Glomerulonephritis

Related Drugs and Biologics

1. Complement System Proteins (Complement)
2. Immunoglobulin G (IgG)
3. Proteins (Proteins, Gene)
4. Autoantibodies
5. Antigen-Antibody Complex (Immune Complex)
6. Complement C3b (C3bi)
7. Complement 3d Receptors (Complement Receptor 2)
8. Propidium (Propidium Iodide)
9. ofatumumab
10. Complement Factor B (Factor B)

Related Therapies and Procedures

1. Lasers (Laser)
2. Plasmapheresis
3. Transplants (Transplant)
4. Plasma Exchange
5. Photochemotherapy (Photodynamic Therapy)