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MELAS Syndrome (Syndrome, MELAS)

A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
Also Known As:
Syndrome, MELAS; Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode
Networked: 186 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Stroke (Strokes)
2. Lactic Acidosis
3. Mitochondrial Diseases (Mitochondrial Disease)
4. Sensorineural Hearing Loss
5. Mitochondrial Myopathies (Mitochondrial Myopathy)

Experts

1. Scaglia, Fernando: 6 articles (09/2015 - 01/2006)
2. El-Hattab, Ayman W: 5 articles (09/2015 - 04/2012)
3. Craigen, William J: 4 articles (03/2014 - 04/2012)
4. Emrick, Lisa T: 4 articles (03/2014 - 04/2012)
5. Wei, Yau-Huei: 4 articles (07/2007 - 01/2002)
6. Wei, Y H: 4 articles (12/2001 - 01/2000)
7. Pang, C Y: 4 articles (12/2001 - 01/2000)
8. Qi, Yu: 3 articles (04/2013 - 12/2008)
9. Wong, Lee-Jun C: 3 articles (04/2012 - 06/2004)
10. Lee, H C: 3 articles (12/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to MELAS Syndrome:
1. Arginine (L-Arginine)FDA Link
2. CitrullineIBA
3. Mitochondrial encephalopathyIBA
4. Carnitine (L-Carnitine)FDA LinkGeneric
5. coenzyme Q10 (CoQ10)IBA
6. Mitochondrial DNA (mtDNA)IBA
7. Leu Transfer RNAIBA
8. Pyruvic Acid (Pyruvate)IBA
9. XenonIBA
10. DNA (Deoxyribonucleic Acid)IBA

Therapies and Procedures

1. Artificial Respiration (Mechanical Ventilation)
2. Cochlear Implantation
3. Cochlear Implants (Cochlear Implant)
4. Fundoplication
5. General Anesthesia