Catalytic Antibodies

03/24/2009 - "Although initially perceived as potentially deleterious, catalytic antibodies have been proposed to participate in the removal of metabolic wastes and in protection against infection. "
04/01/2005 - "Although initially perceived as potentially harmful, catalytic antibodies have been proposed as participants in the removal of metabolic wastes and protection against infection. "
03/15/2005 - "Although initially perceived as potentially deleterious, catalytic antibodies have been proposed to participate in removal of metabolic wastes and protection against infection. "
02/01/2023 - "Catalytic antibodies can continue to play a role and even fully prevent the emergence of autoimmune disorders, especially in the field of infection and immunity, where the process of its occurrence and development often takes a long time. "
01/01/2017 - "Furthermore, naturally occurring catalytic antibodies to microbial determinants have been correlated with resistance to infection. "

07/29/2020 - "In this review, catalytic antibodies will be considered in more detail, since their formation is associated with inflammatory and autoimmune diseases. "
12/01/2005 - "Catalytic antibodies (CAbs) occur naturally in healthy individuals where they may form part of the innate immune system, but are preferentially found in those with autoimmune disease. "
07/18/2005 - "Various catalytic antibodies or abzymes (Abzs) have been detected recently in the sera of patients and animals with many autoimmune diseases, where their presence is most probably associated with autoimmunization. "
01/01/2012 - "Growing evidence suggests important functional roles for catalytic antibodies in homeostasis, autoimmune disease and protection against infection. "
01/13/2017 - "Many naturally occurring catalytic antibodies have since been isolated from human sera and associated with positive and negative outcomes in autoimmune disease and infection. "

12/01/2001 - "The specific activities of these catalytic antibodies varied in the range from 1.83 up to 3.33 kat/kg, which is about one order of magnitude higher than that for IgGs from the sera of cancer patients. "
06/01/1993 - "The approach in this study demonstrates the use of catalytic antibody technology in medicine and may be applicable to drugs with undesirable effects, particularly in the field of cancer therapy."
12/01/1990 - "We also review recent reports in which investigators have used anti-catalytic antibodies and/or gene transfection to demonstrate that uPA is directly involved in tumor cell invasion and metastasis."
09/01/2002 - "Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation."
11/01/2002 - "Prodrug activation by catalytic antibodies (abzymes) conjugated with anti-tumor antibodies, called antibody-directed abzyme prodrug therapy (ADAPT), has been proposed as a strategy for site-specific drug delivery systems for anti-tumor drugs. "

11/01/2017 - "[Exceptional Diversity of Catalytic Antibodies with Varying Activity in the Blood of Autoimmune and Viral Disease Patients]."
07/01/2003 - "Catalytic antibodies in healthy humans and patients with autoimmune and viral diseases."
11/08/2022 - "Several viral diseases are known to trigger autoimmune processes, and the appearance of catalytic antibodies with DNase activity is one of the earliest markers of several autoimmune pathologies. "
06/01/2004 - "In patients with some autoimmune and viral diseases, catalytic antibodies also contribute to alternative pathways of DNA hydrolysis. "

05/01/2008 - "Catalytic antibodies to amyloid beta peptide in defense against Alzheimer disease."
04/01/2010 - "We review attempts to treat Alzheimer disease with antibodies that bind amyloid beta peptide (Abeta) and the feasibility of developing catalytic antibodies for this purpose. "
01/01/2024 - "Single-chain variable fragment (scFv) HS72 is a catalytic antibody that specifically degrades amyloid β-protein 1-42 (Aβ42) aggregates in vitro or reduces the level or burden of Aβ42 deposits/plaques in the brains of mice with Alzheimer disease pathology. "
04/01/2013 - "These questions were discussed in sections covering modified Igs with modified efficacy including catalytic antibodies, the role of Fc receptors and complement inducing autoimmune mediated damage, Ig therapy beyond IgG in particular taking a look at the role of IgA and the therapeutic consequences of the different etiologies of excess amyloid beta in Alzheimer's disease and patients with Downs' syndrome. "