|2.||End Stage Liver Disease
|5.||Liver Diseases (Liver Disease)
|1.||Lee, William M: 49 articles (01/2016 - 11/2002)|
|2.||Dhawan, Anil: 32 articles (10/2015 - 08/2002)|
|3.||Butterworth, Roger F: 30 articles (09/2014 - 08/2002)|
|4.||Acute Liver Failure Study Group: 29 articles (06/2015 - 03/2003)|
|5.||Bernal, William: 28 articles (01/2016 - 02/2002)|
|6.||Wendon, Julia: 27 articles (07/2015 - 02/2002)|
|7.||Jalan, Rajiv: 24 articles (01/2016 - 01/2002)|
|8.||Jaeschke, Hartmut: 22 articles (11/2015 - 01/2010)|
|9.||Mitry, Ragai R: 19 articles (01/2015 - 01/2003)|
|10.||Larsen, Fin Stolze: 19 articles (09/2013 - 03/2002)|
12/24/2015 - "This study aimed to explore the protective effects and mechanisms of the polysaccharide extracts of Sea buckthorn (HRP) berries against lipopolysaccharide (LPS) and d-galactosamine hydrochloride (d-GalN)-induced acute liver failure in mice. "
12/01/2015 - "Here, we explored protective effects of protostemonine (PSN), on mouse acute liver failure induced by lipopolysaccharide/d-galactosamine (LPS/GalN). "
04/01/1999 - "We have established an improved model of fulminant hepatic failure in the pig by administration of an aminosugar d-galactosamine hydrochloride. "
01/01/2014 - "LPS pretreatment ameliorates D-galactosamine/lipopolysaccharide-induced acute liver failure in rat."
04/01/2012 - "Gene transfer of c-met confers protection against D-galactosamine/lipopolysaccharide-induced acute liver failure."
|2.||Acetaminophen (Paracetamol)FDA LinkGeneric
01/01/2014 - "These data collectively demonstrated a RIPK-dependent necrotic mechanism operates in the APAP-injured liver and inhibition of this pathway may be beneficial for APAP-induced fulminant hepatic failure. "
01/01/2015 - "• Prognostication in acetaminophen-induced acute liver failure (APAP-ALF) is challenging beyond admission • Little has been published regarding the use of King's College Criteria (KCC) beyond admission and KCC has shown limited sensitivity in subsequent studies • Classification and Regression Tree (CART) methodology allows the development of predictive models using binary splits and offers an intuitive method for predicting outcome, using processes familiar to clinicians • Data from the ALFSG registry suggested that CART prognosis models for the APAP population offer improved sensitivity and model performance over traditional regression-based KCC, while maintaining similar accuracy and negligibly worse specificity • KCC-CART models offered modest improvement over traditional KCC, with NEW-CART models performing better than KCC-CART particularly at late time points."
10/01/2001 - "The anhepatic model is very useful for validating new supportive measures to bridge the period between the onset of fulminant hepatic failure and the time at which a suitable organ becomes available and, despite the many difficulties involved in their development, hepatotoxic models may still be useful for mimicking an acetaminophen overdose. "
09/01/2013 - "Acetaminophen-induced acute liver failure cured by integrative therapy of Chinese and Western medicine--a case report."
09/01/2003 - "Our aim was to assess the efficacy of the liver dialysis unit (LDU) in the treatment of patients with acetaminophen-induced fulminant hepatic failure. "
|3.||Acetylcysteine (Siran)FDA LinkGeneric
05/01/2010 - "N-acetylcysteine seems to be beneficial for patients with acute liver failure caused by medications or herbal agents."
05/01/2009 - "The aim of the study was to investigate the in vitro effects of sera from children with acute liver failure (ALF) who had received N-acetylcysteine (NAC) on the metabolic and synthetic activity of cryopreserved human hepatocytes. "
01/01/2006 - "N-acetylcysteine may reduce mortality in patients with fulminant hepatic failure (Peto OR 0.26, 95% CI 0.09 to 0.94, one trial). "
05/01/2000 - "This study suggests that N-acetylcysteine administration should be considered in all patients with acute liver failure."
08/01/2013 - "[Acute liver failure -- does N-acetylcysteine improve the prognosis in children?]."
12/01/2011 - "Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice."
12/01/2006 - "We investigated the protective effects of GB on thioacetamide (TAA)-induced fulminant hepatic failure in rats. "
12/01/2006 - "Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats."
06/01/2013 - "A previous study demonstrated an increase of KYNA synthesis in the brain of rats with thioacetamide (TAA)-induced acute liver failure. "
03/01/2007 - "In summary, the present study revealed that oxidative stress prevails in different cerebral regions analyzed during thioacetamide-induced acute liver failure with more pronounced effects on pons medulla and cerebral cortex."
|5.||Carbon Tetrachloride (Tetrachloromethane)IBA
09/01/2015 - "This study aimed to determine whether a controlled portal blood arterialization by a liver extracorporeal device (L.E.O2 NARDO) is effective in treating acute hepatic failure (AHF) induced in swine by carbon tetrachloride (CCl4) administration. "
02/01/2014 - "Protective effects of Ephedra pachyclada extract on mouse models of carbon tetrachloride- induced chronic and acute liver failure."
05/01/1998 - "The present study is an attempt to delineate location and function of transplanted hepatocytes and also the overall survival of these cells with a fluorescent in situ hybridization (FISH) technique using a Y-chromosome-specific probe in a carbon tetrachloride (CCl4)-induced mice model of fulminant hepatic failure. "
05/01/2015 - "The therapeutic effects of 3D-cultured hUC-MSCs on carbon tetrachloride (CCl4)-induced acute liver failure in mouse models were examined. "
02/01/2014 - "Then, we examined possible in vivo hepatoprotective effects of EP extract on mouse models of carbon tetrachloride (CCl4)-induced chronic and acute liver failure. "
01/01/2010 - "These findings further support a role for selective brain-derived cytokines in the pathogenesis of the cerebral complications in acute liver failure and suggest that anti-inflammatory strategies could be beneficial in their prevention."
01/01/2015 - "The dysregulated cytokine metabolism and activity are crucial to the development of fulminant hepatic failure (FHF), and many different cytokines have been identified. "
01/01/2015 - "In acute liver failure (ALF), the UII/UT system can promote the production and release of proinflammatory cytokines, inducing an inflammatory injury response in liver tissue. "
01/01/2014 - "Acute liver failure initiates a sterile inflammatory response with release of cytokines and innate immune cell infiltration in the liver. "
06/01/2013 - "A robust neuroinflammatory response characterized by microglial activation and increased brain production of pro-inflammatory cytokines is common in acute liver failure (ALF). "
01/01/1985 - "Charcoal haemoperfusion also reduced the incidence of cerebral oedema which is a major cause of death in fulminant hepatic failure. "
09/25/1982 - "Earlier charcoal haemoperfusion in fulminant hepatic failure."
01/01/1982 - "The increased platelet adhesiveness might predispose to the formation of platelet aggregates in the blood observed during charcoal haemoperfusion in patients with fulminant hepatic failure."
01/01/1980 - "The effects of 8-hour haemoperfusion through an activated charcoal column on fulminant hepatic failure were assessed in 10 dogs. "
01/01/1980 - "Haemoperfusion through activated charcoal in dogs with fulminant liver failure."
|8.||Alprostadil (Muse)FDA LinkGeneric
05/01/2000 - "In conclusion, the hepatic arterial infusion of PGE1 may be useful in the treatment of acute liver failure."
05/01/2000 - "Efficacy of hepatic arterial infusion of prostaglandin E1 in the treatment of postoperative acute liver failure--report of a case."
03/01/2000 - "Prostaglandin E1 (PGE1) treatment of humans and rodents during acute hepatic failure ameliorates different parameters of hepatic dysfunction. "
09/01/1989 - "As a result of the beneficial effect of Prostaglandin E1 infusion in patients with fulminant hepatic failure, this trial was conducted to determine whether PGE1 would be of value in primary nonfunction. "
10/01/2001 - "In order to reduce risk for postoperative acute liver failure, prostaglandin E1 (PGE1) was administered either from the hepatic artery (HA) or the superior mesenteric artery (SMA) in four high-risk cases undergoing major hepatic resection. "
|9.||Lactic AcidFDA LinkGeneric
02/01/2003 - "Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study."
01/01/2015 - "Real-time assessment of ¹³C metabolism reveals an early lactate increase in the brain of rats with acute liver failure."
08/01/2014 - "Raised serum lactate, positive family history (in first case), and absence of other causes of acute liver failure. "
06/01/2014 - "This work investigated the effect of the intragastric administration of five lactic acid bacteria from healthy people on acute liver failure in rats. "
07/01/2010 - "Lactate is important in determining prognosis in acute liver failure."
|10.||Adenosine Triphosphate (ATP)IBA
03/01/2008 - "The aim of this study was to test the safety and efficacy of exogenous ATP at various doses in a rat model of acute liver failure. "
03/01/2008 - "Further studies involving a wider range of ATP doses and different routes and frequency of ATP administration are required to determine whether exogenous ATP has therapeutic value in the treatment of acute liver failure."
03/01/2008 - "These findings suggest that exogenous ATP does not improve and indeed at high doses may impair survival in rats with acute liver failure. "
02/01/2003 - "These findings indicate that hepatic ATP levels as measured by 31P MRS provide a noninvasive indication of the severity of liver damage and serve as a useful prognostic indicator of outcome in this model of acute liver failure."
11/01/1996 - "In conclusion, alanine is effective for the treatment of experimental acute liver failure, probably caused by promotion of ATP synthesis. "
03/01/2005 - "Liver transplantation is the best treatment for fulminant hepatic failure, with a 1-year patient survival rate of 61.3%. "
05/01/2004 - "The most successful therapy for acute liver failure is liver transplantation. "
10/01/2000 - "Despite an improved understanding of the pathogenesis of complicating cerebral oedema and advances in general supportive care, it is likely that the most severely affected patients with acute liver failure due to viral causes will survive only with liver transplantation, at least until approaches for promoting adequate liver regeneration are successfully developed and implemented."
01/01/1999 - "Survival post liver transplantation for acute liver failure has improved and most recipients can expect a 70% five year survival."
03/27/1997 - "Orthotopic liver transplantation is the most effective treatment for fulminant hepatic failure. "
|2.||Transplantation (Transplant Recipients)
05/01/2011 - "Hepatocyte transplantation of 2×10(7) cells into spleen showed the best results in the acute hepatic failure rat."
05/01/1992 - "In contrast, the prognosis of fulminant hepatic failure has been dramatically improved by OLT, once efficient organization systems allowed adequate organ supply and emergency transplantation within a few hours. "
01/01/2011 - "Intraperitoneal transplantation of encapsulated immortalized hepatocytes significantly improved survival of mice with acute liver failure by providing metabolic support and without modifying liver regeneration. "
01/01/1986 - "Therapeutic efficacy of the transplantation of isolated hepatocytes in rats with surgically induced acute hepatic failure: a study of the mechanism."
04/01/2011 - "Human hepatocyte transplantation to treat liver-based metabolic deficiencies and acute liver failure has shown promising early improvement in liver function; however, long-term success has not been achieved. "
|3.||Artificial Liver (Bioartificial Liver)
01/01/2005 - "Animal models of fulminant hepatic failure (FHF) are important for studying the pathophysiology of this process and for evaluation of the efficacy of artificial and bioartificial liver support systems. "
10/15/2013 - "Albumin dialysis with the Molecular Adsorbent Recirculating System (MARS) (Gambro, Lund, Sweden), a noncell artificial liver support device, may be beneficial in acute liver failure (ALF). "
02/01/2009 - "We compared the clinical efficacy of high-flow dialysate continuous hemodiafiltration (HFCHDF) performed as artificial liver support (ALS) in fulminant hepatic failure (FHF) with those of conventional ALS techniques. "
11/01/2011 - "The application of newly developed multi-layer flat-plate bioartificial liver system was effective in the treatment of canines with acute liver failure."
01/01/2010 - "On-line hemodiafiltration was effective in patients with acute liver failure, and consciousness was maintained for the duration of artificial liver support, even in those in whom it was considered that hepatic function was completely abolished."
10/01/2002 - "Acute Liver Failure (ALF) still presents high mortality rates, and liver transplant is the only treatment with proven efficacy. "
11/01/1996 - "The only clinically proven effective treatment of fulminant hepatic failure (FHF) is orthotopic liver transplant (OLT). "
07/01/2014 - "This eventually resulted in fulminant liver failure and was effectively treated with living-related donor liver transplant and anti-viral medication. "
08/01/2015 - "In this study, we sought to evaluate the results of liver transplant as a treatment for acute liver failure. "
04/01/2015 - "Child-Turcotte-Pugh A patients, deceased-donor liver transplants, and liver transplants performed for fulminant hepatic failure were not included in this study. "
|5.||Drug Therapy (Chemotherapy)
04/21/2006 - "Both symptoms remitted following chemotherapy, suggesting swift diagnosis and administration of chemotherapy to be effective in treatment of fulminant hepatic failure and encephalopathy."
04/01/2012 - "Acute liver failure related to chemotherapy."
07/07/2011 - "Chemotherapy-induced HBV reactivation may ultimately lead to terminal acute liver failure. "
01/01/2011 - "Here, we describe the case of a 78-year-old woman with acute liver failure secondary to infiltration with cll being unresponsive to chemotherapy and causing death. "
08/01/2010 - "Antituberculosis therapy drug-induced liver injury and acute liver failure."