|3.||Temporal Lobe Epilepsy
|5.||Partial Epilepsies (Epilepsy, Partial)
|1.||Ferini-Strambi, Luigi: 10 articles (01/2013 - 04/2002)|
|2.||Hirose, Shinichi: 9 articles (11/2015 - 01/2002)|
|3.||Kaneko, Sunao: 8 articles (11/2015 - 01/2002)|
|4.||Berkovic, Samuel F: 8 articles (08/2015 - 07/2002)|
|5.||Combi, Romina: 8 articles (01/2013 - 08/2002)|
|6.||Okada, Motohiro: 7 articles (11/2015 - 01/2002)|
|7.||Steinlein, Ortrud K: 7 articles (03/2012 - 01/2002)|
|8.||Scheffer, Ingrid E: 6 articles (09/2015 - 04/2003)|
|9.||Becchetti, Andrea: 6 articles (04/2015 - 08/2006)|
|10.||Lester, Henry A: 6 articles (01/2013 - 07/2003)|
|1.||topiramate (Topamax)FDA LinkGeneric
12/01/2006 - "Aim of this study was to evaluate the efficacy and tolerability of the antiepileptic drug topiramate (TPM) in a sample of patients with nocturnal frontal lobe epilepsy (NFLE). "
02/01/2007 - "Topiramate in frontal lobe epilepsy."
12/01/2006 - "Topiramate treatment for nocturnal frontal lobe epilepsy."
02/01/2007 - "Frontal lobe epilepsy (FLE) is a type of epilepsy that is difficult to treat and there are few studies about the use of topiramate (TPM). "
01/01/2010 - "For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 277 patients with seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic frontal lobe epilepsy (FLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years. "
|2.||Carbamazepine (Tegretol)FDA LinkGeneric
04/01/2008 - "Psychosis with frontal lobe epilepsy responds to carbamazepine."
07/01/1998 - "After the recording of them, by means of full-night video-polysomnography, they were both diagnosed as having nocturnal frontal lobe epilepsy as the main sleep disorder and then successfully treated with carbamazepine."
09/01/1995 - "[Exacerbation of complex partial seizures by carbamazepine in a child with frontal lobe epilepsy]."
07/01/2002 - "Molecular modelling of the interactions of carbamazepine and a nicotinic receptor involved in the autosomal dominant nocturnal frontal lobe epilepsy."
09/01/1999 - "Mutated nicotinic receptors responsible for autosomal dominant nocturnal frontal lobe epilepsy are more sensitive to carbamazepine."
|3.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
08/01/2001 - "Divalproex-lamotrigine combination therapy is a reasonable alternative in intractable frontal lobe epilepsy."
01/01/2010 - "[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic frontal lobe epilepsy in children]."
08/01/2010 - "ECoG studies of valproate, carbamazepine and halothane in frontal-lobe epilepsy induced by head injury in the rat."
|4.||Anticonvulsants (Antiepileptic Drugs)IBA
06/01/1998 - "Based on the location of electrodes in the frontal neocortex, the characteristic seizure pattern, and the low pharmacological sensitivity of the seizures to standard antiepileptics, the modified CRS model most likely represents a new model of localization-related seizures occurring in frontal lobe epilepsy and may thus be used in the search for novel drugs with higher efficacy against this difficult-to-treat type of epilepsy."
12/01/2015 - "The objective of this study was to provide a better understanding of the verbal learning and memory (VLM) patterns that might differentiate children with frontal lobe epilepsy (FLE) from children with temporal lobe epilepsy (TLE) and to examine the impact of variables thought to influence outcomes (seizure laterality, age at seizure onset, age at assessment, epilepsy duration, number of antiepileptic drugs). "
10/01/2012 - "Management of nocturnal frontal lobe epilepsy include a first-step pharmacological approach with antiepileptic drugs (eg, carbamazepine, oxcarbazepine or other drugs effective on partial seizures), but surgical options may be considered in drug refractory patients. "
|5.||Adrenocorticotropic Hormone (ACTH)FDA Link
06/01/2014 - "Our study demonstrates that ACTH may represent an effective treatment for frontal lobe epilepsy with secondary bilateral synchrony. "
06/01/2014 - "We evaluated the short, medium, and long-term evolution of patients with frontal lobe epilepsy and secondary bilateral synchrony on the EEG, who received ACTH treatment. "
06/01/2014 - "Can ACTH therapy improve the long-term outcome of drug-resistant frontal lobe epilepsy?"
|6.||Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
09/15/2010 - "These compounds appear to be particularly effective for treatment of nocturnal frontal lobe epilepsy, which can be caused by mutant neuronal nicotinic receptors. "
11/01/2015 - "We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG), in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit (CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). "
08/01/2015 - "Nocturnal frontal lobe epilepsy (NFLE) can be sporadic or autosomal dominant; some families have nicotinic acetylcholine receptor subunit mutations. "
04/14/2015 - "We assessed the mutation frequency in nicotinic acetylcholine receptor (nAChR) subunits CHRNA4, CHRNB2, and CHRNA2 in a cohort including autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and sporadic nocturnal frontal lobe epilepsy (NFLE). "
01/01/2015 - "The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy."
|7.||oxcarbazepine (Trileptal)FDA LinkGeneric
10/01/2008 - "Oxcarbazepine in nocturnal frontal-lobe epilepsy: a further interesting report."
11/01/2007 - "We report on eight children between ages 4-16 years with nocturnal frontal-lobe epilepsy who had a dramatic response to oxcarbazepine at standard recommended doses, some of whom were refractory to previous antiepileptic medications. "
11/01/2007 - "Oxcarbazepine in children with nocturnal frontal-lobe epilepsy."
11/01/2007 - "Our patients demonstrate the efficacy of oxcarbazepine for nocturnal hyperkinetic seizures in children with nocturnal frontal-lobe epilepsy."
09/15/2010 - "Effect of carbamazepine and oxcarbazepine on wild-type and mutant neuronal nicotinic acetylcholine receptors linked to nocturnal frontal lobe epilepsy."
|8.||Potassium Channels (Potassium Channel)IBA
02/01/2014 - "Some studies found that the human potassium channel, subfamily T, member 1 (KCNT1) is the candidate gene causing malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy which are all rare genetic generalized epilepsies. "
11/01/2012 - "We performed genomic mapping of a family with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and intellectual and psychiatric problems, identifying a disease-associated region on chromosome 9q34.3. Whole-exome sequencing identified a mutation in KCNT1, encoding a sodium-gated potassium channel subunit. "
11/01/2012 - "Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy."
09/01/2015 - "Autosomal dominant mutations in the sodium-gated potassium channel subunit gene KCNT1 have been associated with two distinct seizure syndromes, nocturnal frontal lobe epilepsy (NFLE) and malignant migrating focal seizures of infancy (MMFSI). "
01/01/2013 - "Nocturnal frontal lobe epilepsy has been historically considered a channelopathy caused by mutations in subunits of the neuronal nicotinic acetylcholine receptor or in a recently reported potassium channel. "
|9.||Acetylcholine (Acetylcholine Chloride)FDA Link
01/01/1999 - "The aim of the study was to describe in detail the electroclinical findings associated with a mutation in the acetylcholine receptor in a Norwegian family with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). "
11/01/2012 - "Nocturnal frontal lobe epilepsy and the acetylcholine receptor."
11/19/2008 - "Mutations of genes encoding alpha4, beta2, or alpha2 subunits (CHRNA4, CHRNB2, or CHRNA2, respectively) of nAChR [neuronal nicotinic ACh (acetylcholine) receptor] cause nocturnal frontal lobe epilepsy (NFLE) in human. "
09/09/2008 - "Mutations of the neuronal nicotinic acetylcholine (nACh) receptor identified in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) lead to increased sensitivity to ACh. "
08/01/2005 - "Rat orthologs of five mutations linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)-alpha4(S252F), alpha4(S256L), alpha4(+L264), beta2(V262L), and beta2(V262M)-reduced 2 mM Ca(2+) potentiation of the alpha4beta2 1 mM acetylcholine response by 55 to 74%. "
|10.||Immunoglobulin E (IgE)IBA
11/01/2015 - "The patients were selected for the frontal lobe epilepsy (FLE), medial temporal lobe epilepsy (MTLE), and idiopathic generalized epilepsy (IGE). "
11/01/2015 - "The study reported here discusses the duration of the generalized tonic-clonic seizures (GTCS) among frontal lobe epilepsy (FLE), medial temporal lobe epilepsy (MTLE) and idiopathic generalized epilepsy (IGE). "
08/01/2008 - "On the G-SAS, patients with a diagnosis of temporal lobe epilepsy (TLE) reported a mean [sd] G-SAS score of 2.0 [5.7], significantly higher than patients with frontal lobe epilepsy (FLE) (0.6 [1.7]) and idiopathic generalized epilepsy (IGE) (0.4 [1.4]). "
10/01/2009 - "The alpha4 subunit gene (CHRNA4) of the neuronal nicotinic acetylcholine receptor (nAChR), linked to an idiopathic partial epilepsy, autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), may also play a key role in the development of the idiopathic generalized epilepsy syndrome (IGE), juvenile myoclonic epilepsy (JME). "
01/01/2014 - "Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. "
04/01/2013 - "Subject was a patient with right frontal lobe epilepsy who underwent invasive presurgical evaluation with subdural electrodes placed on the medial and lateral frontal cortices. "
04/01/2007 - "However, in a case of frontal lobe epilepsy, asynchronous ictal ECoG discharges were recorded on 10 electrodes of convexity but no ictal EEG activity was recorded. "
07/15/2005 - "Presurgical evaluation of frontal lobe epilepsy (FLE) remains a challenging issue and frequently requires invasive depth electrode recording. "
07/15/2005 - "1H-MRS imaging in intractable frontal lobe epilepsies characterized by depth electrode recording."
|2.||Drug Therapy (Chemotherapy)
05/01/2011 - "Given the impact of these complications, there is a need for studies of the etiology of frontal lobe epilepsy-associated cognitive and behavioral disturbances, as well as pharmacotherapy-resistance."
10/01/2008 - "We illustrate the case of a 36-year-old male patient with frontal lobe epilepsy who presented with isolated cephalic auras described as a nonvertiginous sense of head movement without observable clinical signs after his habitual partial motor seizures were controlled with pharmacotherapy. "
|3.||Vagus Nerve Stimulation
|4.||Deep Brain Stimulation
|5.||Continuous Positive Airway Pressure