|1.||Gardner, Dale R: 6 articles (07/2014 - 06/2002)|
|2.||Zhao, Baoyu: 3 articles (10/2015 - 07/2007)|
|3.||Kalraiya, Rajiv D: 3 articles (05/2015 - 09/2006)|
|4.||Lityńska, Anna: 3 articles (04/2015 - 01/2006)|
|5.||Tong, Dewen: 3 articles (12/2012 - 07/2007)|
|6.||Driemeier, David: 3 articles (01/2012 - 06/2002)|
|7.||Asano, Naoki: 3 articles (07/2008 - 12/2003)|
|8.||Oredipe, O A: 3 articles (11/2003 - 01/2003)|
|9.||Sridhar, Rajagopalan: 3 articles (10/2003 - 01/2003)|
|10.||Furbert-Harris, Paulette M: 3 articles (10/2003 - 01/2003)|
01/01/1989 - "In this report, studies are presented to show that swainsonine was effective in activating peritoneal macrophages to cytotoxicity against tumor cells. "
01/01/1990 - "The present studies are based on our recent report that murine peritoneal macrophages are activated by swainsonine (Grzegorzewski, K.; Newton, S.A.; Akiyama, S.K.; Sharrow, S.; Olden, K.; White, S.L., Cancer Commun. "
01/01/1990 - "In studies employing intravenously injected tumor cells, pretreatment of mice with swainsonine-containing drinking water provided a reproducible protective effect for the host. "
01/01/2015 - "Swainsonine (SW), an extract from Astragalus membranaceus, represents a new class of compounds that inhibit growth and induce apoptosis in a cancer model. "
12/01/2012 - "Swainsonine, an extract from Astragalus membranaceus, exhibits broad inhibition of growth and pro-apoptotic activity in a number of tumor types. "
|2.||Melanoma (Melanoma, Malignant)
05/01/2006 - "In this study we examined the influence of swainsonine (SW) on adhesion, wound healing and haptotactic migration on FN, comparing the responses of different human melanoma cell lines: primary WM35 and metastatic WM9, WM239 and A375. "
04/01/2015 - "Lectin precipitation, enzyme digestion and the use of swainsonine (SW) showed that αvβ3 integrin glycosylation differs significantly between primary and metastatic melanoma cells. "
08/01/2014 - "Swainsonine treatment, by reducing the amount of β1,6-branches, significantly decreased cell attachment in all cases, but reduction of wound healing efficiency was compromised only in cutaneous melanoma cell. "
03/15/1990 - "Graded doses of swainsonine were administered either orally or via implanted Alzet miniosmotic pumps to athymic nude mice bearing subcutaneously implanted human MeWo melanoma cells. "
03/15/1990 - "In this report we demonstrate that swainsonine also reduces the growth rate of human melanoma cells in vitro and in vivo. "
05/01/2007 - "We therefore conclude that swainsonine could inhibit cell proliferation in vitro and the growth of human gastric carcinoma in vivo. "
05/01/2007 - "In order to investigate the effects and mechanisms of swainsonine on the human gastric carcinoma SGC-7901 cell, we carried out in vivo and in vitro experiments. "
05/01/2007 - "Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine."
07/05/1989 - "In vivo, the growth rate of HT29m human colon carcinoma tumors in athymic nude mice was reduced by supplementing their drinking water with swainsonine (49%) or by administering HuIFN-alpha 2 systemically (53%); combining these treatments reduced tumor growth by 78%. "
01/01/2006 - "Treatment of T24 cells with swainsonine reduced the rate of bladder carcinoma cell migration by 16%, indicating the role of beta1,6 branched complex type glycans in this process. "
|4.||Neoplasm Metastasis (Metastasis)
05/01/2015 - "Further, inhibition of N-glycosylation with Swainsonine (SW) which drastically reduces metastasis of B16F10 cells in gal-3(+/+) mice, did not affect lung metastasis when assessed in gal-3(-/-) mice. "
11/01/1997 - "The kinetics of inhibition of metastasis by the immunomodulator swainsonine (SW) is effective 1 to 3 days after administration. "
07/05/1989 - "Swainsonine inhibition of spontaneous metastasis."
03/15/1988 - "These results indicate (a) an absolute requirement for a functional NK cell population in order for swainsonine to exert its inhibitory effects on experimental metastasis, and (b) that the antimetastatic activity of swainsonine is mediated primarily through the ability of the drug to augment NK cell reactivity. "
01/01/1988 - "Use of antiadhesive peptide and swainsonine to inhibit metastasis."
|1.||mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase
|9.||Apolipoproteins E (ApoE)
|10.||Aminocaproic Acids (EAC)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)
|4.||Transplantation (Transplant Recipients)