|4.||Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
|1.||Leirisalo-Repo, M: 9 articles (01/2013 - 05/2001)|
|2.||Inman, Robert D: 6 articles (06/2013 - 07/2005)|
|3.||Kuipers, J G: 6 articles (09/2007 - 01/2001)|
|4.||Zeidler, H: 6 articles (11/2006 - 01/2001)|
|5.||Sieper, J: 6 articles (06/2002 - 01/2000)|
|6.||Granfors, Kaisa: 5 articles (01/2013 - 08/2002)|
|7.||Repo, H: 5 articles (01/2013 - 09/2005)|
|8.||Bas, S: 5 articles (09/2009 - 06/2001)|
|9.||Sieper, Joachim: 5 articles (11/2006 - 08/2003)|
|10.||Rastawicki, Waldemar: 4 articles (01/2014 - 01/2004)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
01/01/2010 - "Although in the Netherlands a Ct induced reactive arthritis is not yet treated with antibiotics, a recent published clinical trial in patients with a chronic Ct induced reactive arthritis showed a significant reduction in complaints in the group treated with a combination of antibiotics for 6 months, compared to the placebo group. "
07/01/2000 - "Antibiotics seem not to be effective in postenteric reactive arthritis. "
05/01/1997 - "We conclude that experimental Yersinia reactive arthritis can be cured by antibiotics introduced at an early phase of arthritic development. "
05/01/2010 - "Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial."
06/01/2013 - "Antibiotics for treatment of reactive arthritis: a systematic review and metaanalysis."
|2.||Methotrexate (Mexate)FDA LinkGeneric
01/01/2010 - "Efficacy of methotrexate in the treatment of a HLA-B27-positive Japanease patient with reactive arthritis."
01/01/2010 - "We report a case of reactive arthritis in a 21-year-old man who was successfully treated with methotrexate. "
11/01/1985 - "A review of methotrexate therapy in Reiter syndrome."
02/01/1979 - "Methotrexate in Reiter's disease."
06/01/1977 - "Reiter's disease, responding to methotrexate."
|3.||Sulfasalazine (Azulfidine)FDA LinkGeneric
12/01/1996 - "To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is effective in the treatment of reactive arthritis (ReA) that has been unresponsive to nonsteroidal antiinflammatory drug (NSAID) therapy. "
01/01/1997 - "Double blind placebo controlled trial of six months duration comparing sulphasalazine 2-3 g per day (n = 37) with matching placebo (n = 42) in adults with active reactive arthritis (age 19-57 years, median 34). "
12/01/2000 - "Sulfasalazine therapy effectively managed reactive arthritis in this gorilla and should be considered for similarly frequently affected animals. "
12/01/2000 - "Management of reactive arthritis in a juvenile gorilla (Gorilla gorilla gorilla) with long-term sulfasalazine therapy."
10/01/1997 - "Sulfasalazine and human immunodeficiency virus-associated reactive arthritis: comment on the article by Clegg et al."
11/01/1992 - "In this study we have determined the cytokine secretion patterns of 24 CD4+ synovial fluid (SF)-derived T cell clones from 2 patients with Yersinia-induced reactive arthritis, 16 clones specific for different Yersinia antigens and 8 clones as controls. "
06/01/2015 - "In the susceptible SKG strain, Chlamydia-induced reactive arthritis develops as a result of deficient intracellular pathogen control, with antigen-specific TNF production upon dissemination of antigen, and TNF-dependent inflammatory disease."
07/01/2013 - "Role of 30 kDa antigen of enteric bacterial pathogens as a possible arthritogenic factor in post-dysenteric reactive arthritis."
01/01/2008 - "Bacteria and/or their antigens have been implicated in the pathogenesis of reactive arthritis (ReA). "
09/01/2007 - "Human leucocyte antigen (HLA)-B27 is strongly associated with spondyloarthropathies, including reactive arthritis. "
|5.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/01/2011 - "Safety and efficacy of anti-tumor necrosis factor α therapy in ten patients with recent-onset refractory reactive arthritis."
08/01/2008 - "Chlamydia trachomatis is a common aetiological agent for reactive arthritis, and in vitro studies have shown that chlamydial replication is inversely proportional to TNFalpha levels. "
06/01/2015 - "High Chlamydia Burden Promotes Tumor Necrosis Factor-Dependent Reactive Arthritis in SKG Mice."
01/01/2012 - "There is a limited data about the use of tumor necrosis factor-α (TNF-α) blockers in reactive arthritis. "
08/15/2005 - "This finding has provided a rationale for the use of TNFalpha antagonists in the treatment of reactive arthritis; however, the possibility that the triggering microorganism might persist in affected joints and become activated with use of these agents has been of concern. "
|6.||HLA-B27 Antigen (HLA B27 Antigen)IBA
06/01/2007 - "To study innate immune responsiveness of HLA-B27 positive subjects recovered from Yersinia-triggered reactive arthritis (B27 + ReA+). "
02/01/2007 - "This study investigated whether HLA-B27 modulates the innate response to lipopolysaccharide (LPS), a component shared between all Gram negative bacteria that can trigger reactive arthritis. "
01/01/2007 - "This study shows that the SLC 11A1 274T and 823C alleles are associated with susceptibility to reactive arthritis independently of HLA-B27 in Taiwan. "
03/01/2006 - "The study comprised HLA-B27 positive subjects with previous reactive arthritis (B27+ReA+), and B27+ReA- and B27-ReA- subjects (n = 15 each). "
08/01/1990 - "In this study, transgenic mice expressing HLA-B27 and their negative full sibs were infected intravenously with Yersinia enterocolitica 0:8 WA in an attempt to develop an experimental model of reactive arthritis. "
|7.||Interleukin-6 (Interleukin 6)IBA
02/01/2003 - "Recent studies have shown that the urogenital pathogen Chlamydia trachomatis to be a major bacterium triggering reactive arthritis (ReA), and is able to induce interleukin-6 (IL-6) production in human fibroblast-like synovial cells (FSC) in vitro. "
07/01/1989 - "Synovial fluids of patients with rheumatoid arthritis, osteoarthritis, psoriatic arthritis, reactive arthritis and Reiter's syndrome were examined for their concentrations of interleukin 6 (IL-6) in a proliferation assay with the IL-6 dependent hybridoma cell line B13.29 (subclone B9). "
05/01/2011 - "A considerable number of case reports and preclinical studies have shown the benefit of IL-6 blockade therapy in various IMIDs such as systemic lupus erythematosus, adult-onset Still disease, Takayasu arthritis, polyarteritis nodosa, systemic sclerosis, reactive arthritis, dermatomyositis, and polymyositis. "
02/01/1998 - "To evaluate prolactin (PRL) serum levels in prepubertal girls affected with 2 different subtypes of pauciarticular onset juvenile chronic arthritis (JCA) and with previous acute postinfectious arthritis in remission (AA), and to correlate the relationship of PRL versus interleukin 6 (IL-6) serum levels. "
01/01/1992 - "Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus."
|8.||Ciprofloxacin (Cipro)FDA LinkGeneric
07/01/1999 - "No benefit of long-term ciprofloxacin treatment in patients with reactive arthritis and undifferentiated oligoarthritis: a three-month, multicenter, double-blind, randomized, placebo-controlled study."
05/01/1993 - "We conclude that further studies are necessary before the value of prolonged ciprofloxacin treatment of chronic reactive arthritis can be established."
09/01/2003 - "Effect of a three month course of ciprofloxacin on the late prognosis of reactive arthritis."
11/01/2000 - "Patients with yersinia triggered reactive arthritis were double blind randomly allocated to receive treatment with ciprofloxacin 500 mg twice daily orally or placebo during three months. "
11/01/2000 - "Ciprofloxacin v placebo for treatment of Yersinia enterocolitica triggered reactive arthritis."
|9.||Doxycycline (Vibramycin)FDA LinkGeneric
11/01/2006 - "Comparing 10-day and 4-month doxycycline courses for treatment of Chlamydia trachomatis-reactive arthritis: a prospective, double-blind trial."
01/01/1998 - "This anti-collagenolytic doxycycline effects is mediated through inhibition of the enzyme activity and not through degradation of the enzyme, which may have contributed to the reportedly reduced tissue destruction, as has been seen in clinical studies concerning RA as well as reactive arthritis."
12/01/2001 - "To determine whether long term doxycycline improves symptoms in patients with chronic seronegative or reactive arthritis. "
06/01/1991 - "Refractory cases of reactive arthritis may be helped by weekly low-dose oral methotrexate or by long courses of doxycycline. "
10/01/1994 - "In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis."
|10.||Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
12/01/1995 - "To study the occurrence of antineutrophil cytoplasmic antibodies (ANCA) in reactive arthritis (ReA). "
09/01/1996 - "Are antineutrophil cytoplasmic antibodies of immunodiagnostic value in reactive arthritis?"
12/01/1995 - "Antineutrophil cytoplasmic antibodies in reactive arthritis."
03/01/1996 - "Sera from 66 children with active JCA of oligoarticular, polyarticular or systemic onset, 13 sera from patients in disease remission, 15 sera from patients with reactive arthritis, and 11 from Lyme arthritis patients were tested for the presence of anti-neutrophil cytoplasmic antibodies (ANCA) in order to evaluate their diagnostic significance in JCA. "
01/01/2000 - "BPI-ANCA is found in reactive arthritis caused by Yersinia and Salmonella infection and recognise exclusively the C-terminal part of the BPI molecule."
04/01/2013 - "Reiter syndrome is an uncommon complication after intravesical BCG immunotherapy. "
10/01/2003 - "Reiter syndrome is an uncommon complication after intravesical BCG immunotherapy. "
10/01/2003 - "[Reiter syndrome after intravesical Bacillus Calmette-Guerin (BCG) immunotherapy: a case report]."
10/01/2002 - "Reactive arthritis after BCG immunotherapy: T cell analysis in peripheral blood and synovial fluid."
09/13/2002 - "Reactive arthritis can be induced by BCG-immunotherapy. "
09/01/2012 - "Reactive arthritis after the intravesical instillation of BCG."
08/01/2010 - "[Acute reactive arthritis after intravesical instillation of bacillus Calmette-Guérin. "
10/01/2013 - "Intravesical instillation of BCG (ivBCG) is an effective and safe immunotherapy of bladder carcinoma but it may have, as side effect, a reactive arthritis (ReA). "
04/01/2006 - "The review of the literature highlighted that reactive arthritis following BCG intravesical instillation is a complication usually well controlled with the discontinuation of the immunotherapy and nonsteroidal anti-inflammatory drugs (NSAIDs) treatment. "
|3.||Drug Therapy (Chemotherapy)
07/01/2003 - "The role of early antimicrobial chemotherapy for the prevention of reactive arthritis needs to be studied."
11/01/1986 - "We have recently witnessed two attacks of reactive arthritis and keratoderma blenorrhagica occurring in an HLA B27 adult male following chemotherapy on two separate occasions with the same drugs for acute myeloid leukaemia. "
03/01/2010 - "We report the case of reactive arthritis following a Chlamydia urinary tract infection progressing to a chronic course, treated with a short course of high dose tumor necrosis factor antagonist, followed up for over 2 years with prolonged remission, allowing discontinuation of disease modifying antirheumatic drug therapy."
01/01/1960 - "[The treatment of acute inflammatory rheumatism (Bouillaud's disease and Fiessinger-Leroy-Reiter syndrome) by diacetylpyrocatecholcarboxylic acid and its injectable derivative]."
02/01/1995 - "The mainstay of treatment of reactive arthritis is, as always, an anti-inflammatory drug, supplemented by hydrocortisone injections; docycline is available for chlamydia-triggered arthritis and chloroquine or dapsone for more chronic, unresponsive cases."
|5.||Blood Component Removal (Apheresis)