Ribonuclease H (RNase H)

A ribonuclease that specifically cleaves the RNA moiety of RNA:DNA hybrids. It has been isolated from a wide variety of prokaryotic and eukaryotic organisms as well as RETROVIRUSES.

Also Known As:

Networked: 95 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Qilan: 2 articles (11/2021 - 01/2018)
2.	Tavis, John E: 2 articles (11/2021 - 01/2018)
3.	Lockhart, Arianna: 2 articles (11/2019 - 12/2017)
4.	Luke, Brian: 2 articles (11/2019 - 12/2017)
5.	Luke-Glaser, Sarah: 2 articles (11/2019 - 12/2017)
6.	Fan, Jialong: 2 articles (01/2019 - 04/2017)
7.	Liu, Bin: 2 articles (01/2019 - 04/2017)
8.	Tong, Chunyi: 2 articles (01/2019 - 04/2017)
9.	Zhao, Chuan: 2 articles (01/2019 - 04/2017)
10.	Aguilera, Andrés: 2 articles (12/2017 - 10/2008)

Related Diseases

1.	Infections 11/17/2021 - "Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection." 01/01/2019 - "It is found that RNase H activity was upregulated in patients with hepatitis C virus infection. " 04/15/2017 - "The average level of RNase H in serums of HBV infection group was similar to that of control group. " 05/01/2015 - "Two notable structural differences between these groups of genetic elements are 1) the presence in retroviruses of an additional envelope gene, env, which mediates infection, and 2) a specific dual ribonuclease H (RNH) domain encoded by the retroviral pol gene. " 01/25/1991 - "RNase H activity increases markedly after bacteriophage T4 infection of Escherichia coli MIC2003, an RNase H-deficient host. "
2.	Neoplasms (Cancer) 10/12/2020 - "Ultimately, the RNase H-encapsulated nanovesicle efficiently delivered SSOs with RNase H into cultured cancer cells, thereby eliciting the significantly higher gene knockdown compared with empty nanovesicles (without RNase H) or a mixture of nanovesicles with RNase H without encapsulation. " 12/14/2017 - "The diagnostic capability of this assay was demonstrated by monitoring the activity of RNase H in tumor cells. " 06/01/2017 - "Here, we aimed to find the specific quantitative relationship of AMOs targeted to tumor-associated miR-21 through direct comparison of their inactivation efficacies with systematically varied chemical properties, including sequence-specific binding affinity, nuclease resistance, and RNase H activation. " 09/17/1980 - "These results are consistent with a role for RNAase H in DNA replication in rat mammary gland and in R3230Ac mammary tumor." 10/31/2023 - "After reduction by GSH, the opened DNA origami can release the sgRNA/Cas9 complex by RNase H cleavage to achieve a pronounced gene editing of a tumor-associated gene for gene therapy in vivo. "
3.	Leukemia 09/01/1990 - "RNase H of human leukemic cells: a new biological parameter in the study of human leukemias (review)." 08/01/1998 - "Moloney murine leukemia virus-HIV-1 hybrid substrates were constructed which demonstrated that changes to HIV-1 sequences at positions 4 and 6 were sufficient but not optimal for regaining cleavage by the isolated HIV-1 RNase H domain. " 09/01/1990 - "This article reviews the authors' investigation of the enzyme RNase H (EC 3.1.4.34.) in human leukemic cells and presents the accumulated available data, based on which this enzyme is proposed to serve as a new biological parameter in the study of progression of human leukemias. " 01/01/1993 - "These experiments were designed to test the hypothesis that RNase H mediates the MYC antisense-induced reduction in MYC protein observed in the human monocytic leukemia cell line U937. " 01/01/1993 - "Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937."
4.	Liver Diseases (Liver Disease) 03/01/2003 - "To amplify HBV-RNase H gene fragment and expression of RNase H for further use in the studies of HBV associated liver diseases. "
5.	Hepatitis 03/01/1995 - "In this study we define six HLA-A2-restricted CTL epitopes located in the highly conserved reverse transcriptase and RNase H domains of the viral polymerase protein, and we show that the CTL response to polymerase is polyclonal, multispecific, and mediated by CD8+ T cells in patients with acute viral hepatitis, but that it is not detectable in patients with chronic HBV infection or uninfected healthy blood donors. "

Related Drugs and Biologics

1.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
2.	Enzymes
3.	Proteins (Proteins, Gene)
4.	Integrases
5.	Epitopes
6.	RNA (Ribonucleic Acid)
7.	DNA (Deoxyribonucleic Acid)
8.	Messenger RNA (mRNA)
9.	Ribonuclease H (RNase H)
10.	DNA-Directed DNA Polymerase (Polymerases, DNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Art Therapy