|1.||Bennett, C Frank: 2 articles (06/2012 - 03/2012)|
|2.||Inoue, Emi: 1 article (08/2015)|
|3.||Mori, Hiroshi: 1 article (08/2015)|
|4.||Osawa, Yoshiaki: 1 article (08/2015)|
|5.||Watanabe, Tadaaki: 1 article (08/2015)|
|6.||Okazaki, Katsunori: 1 article (08/2015)|
|7.||He, L: 1 article (07/2015)|
|8.||Wang, S S: 1 article (07/2015)|
|9.||Loo, Jacky F C: 1 article (07/2015)|
|10.||Kong, S K: 1 article (07/2015)|
05/01/2015 - "Two notable structural differences between these groups of genetic elements are 1) the presence in retroviruses of an additional envelope gene, env, which mediates infection, and 2) a specific dual ribonuclease H (RNH) domain encoded by the retroviral pol gene. "
01/23/2009 - "Two distinct types of RT inhibitors, both of which block the polymerase activity of RT, have been approved to treat HIV-1 infections, nucleoside analogs (NRTIs) and nonnucleosides (NNRTIs), and there are promising leads for compounds that either block the RNase H activity or block the polymerase in other ways. "
01/01/1980 - "Infection of BHK cells with HSV type 1 does not lead to a pronounced alteration of RNase H II activity but to an increase (3-fold) of the extractable RNase H I activity. "
07/07/2015 - "A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection."
06/09/2006 - "Our lead thioaptamer, R12-2, targets the RNase H domain of the HIV-1 reverse transcriptase (RT) and inhibits viral infection in U373-MAGI-CCR5 cells. "
09/01/1990 - "This article reviews the authors' investigation of the enzyme RNase H (EC 22.214.171.124.) in human leukemic cells and presents the accumulated available data, based on which this enzyme is proposed to serve as a new biological parameter in the study of progression of human leukemias. "
09/01/1990 - "RNase H of human leukemic cells: a new biological parameter in the study of human leukemias (review)."
08/01/1998 - "Moloney murine leukemia virus-HIV-1 hybrid substrates were constructed which demonstrated that changes to HIV-1 sequences at positions 4 and 6 were sufficient but not optimal for regaining cleavage by the isolated HIV-1 RNase H domain. "
01/01/1993 - "These experiments were designed to test the hypothesis that RNase H mediates the MYC antisense-induced reduction in MYC protein observed in the human monocytic leukemia cell line U937. "
01/01/1993 - "Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937."
09/17/1980 - "These results are consistent with a role for RNAase H in DNA replication in rat mammary gland and in R3230Ac mammary tumor."
09/17/1980 - "Compared to the corresponding enzyme from host glands, RNAase H from the R3230AC mammary tumor grown in pregnant and lactating hosts changes similarly, but to a lesser extent. "
09/01/1980 - "Since the RNAase H activity appears to be more stable, the measurement of RNAase H activity with a proper antibody might be useful for assaying tumor cells for the presence of the viral enzyme."
08/01/2015 - "In this study, we examined tumor cells associated with EBL in an 18-year-old cow to reveal that the cells carried at least two different copies of the virus, one of which was predicted to encode a reverse transcriptase (RT) lacking ribonuclease H activity and no integrase. "
09/17/1980 - "RNAase H, which catalyzes the hydrolysis of the RNA moiety of an RNA-DNA hybrid, was measured in the mammary gland of virgin, pregnant, lactating, and weaning Fischer rats and in the R3230AC mammary tumor grown in the same animals. "
|4.||Liver Diseases (Liver Disease)
03/01/1995 - "In this study we define six HLA-A2-restricted CTL epitopes located in the highly conserved reverse transcriptase and RNase H domains of the viral polymerase protein, and we show that the CTL response to polymerase is polyclonal, multispecific, and mediated by CD8+ T cells in patients with acute viral hepatitis, but that it is not detectable in patients with chronic HBV infection or uninfected healthy blood donors. "
|1.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|4.||RNA (Ribonucleic Acid)
|5.||DNA (Deoxyribonucleic Acid)
|6.||Ribonuclease H (RNase H)
|7.||Messenger RNA (mRNA)
|10.||Proteins (Proteins, Gene)
|1.||Drug Therapy (Chemotherapy)