Gram-Positive Bacterial Infections

Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.

Also Known As:

Infections, Gram-Positive Bacterial; Bacterial Infection, Gram-Positive; Bacterial Infections, Gram Positive; Gram Positive Bacterial Infections; Gram-Positive Bacterial Infection; Infection, Gram-Positive Bacterial; Infections, Gram Positive Bacterial; Bacterial Infections, Gram-Positive

Networked: 348 relevant articles (27 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Bacterial Infections and Mycoses: 1
  - Bacterial Infections: 24368
    - Gram-Positive Bacterial Infections: 348

Related Diseases

1.	Endocarditis
2.	Infections
3.	Pneumonia (Pneumonitis)
4.	Sepsis (Septicemia)
5.	Thrombocytopenia (Thrombopenia)

Experts

1.	Haldar, Jayanta: 6 articles (01/2022 - 05/2015)
2.	Lin, Shuimu: 4 articles (10/2021 - 01/2015)
3.	Liu, Shouping: 4 articles (10/2021 - 01/2015)
4.	Sarkar, Paramita: 4 articles (01/2021 - 01/2016)
5.	Yang, Minjie: 3 articles (01/2021 - 01/2017)
6.	Zhang, Jing: 3 articles (01/2021 - 01/2017)
7.	Samaddar, Sandip: 3 articles (01/2020 - 01/2016)
8.	Yarlagadda, Venkateswarlu: 3 articles (01/2020 - 05/2015)
9.	Seleem, Mohamed N: 3 articles (05/2018 - 01/2015)
10.	Sobel, Jack D: 3 articles (07/2011 - 09/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gram-Positive Bacterial Infections:

1.	Vancomycin FDA LinkGeneric 01/01/2021 - "The final consolidated population PK model was used to explore the correlation of pharmacokinetics/pharmacodynamics (PK/PD) indices and efficacy of vancomycin and to provide evidence for the optimized regimen of vancomycin in Chinese pediatric patients with Gram-positive bacterial infection. " 01/01/2018 - "Efficacy of Vancomycin on Gram-Positive Bacterial Infection in Elderly Critical Patients and Risk Factors Associated With Nephrotoxicity." 01/01/2018 - "As the last resort for intractable Gram-positive bacterial infections, vancomycin is losing efficacy with the emergence of vancomycin-resistant bacteria, especially vancomycin-resistant Enterococci (VRE). " 10/01/2016 - "This study aimed to assess whether currently used dosages of vancomycin for treatment of serious gram-positive bacterial infections in intensive care unit patients provided initial therapeutic vancomycin trough levels and to examine possible factors associated with the presence of adequate initial vancomycin trough levels in these patients. " 01/01/2023 - "Vancomycin is considered the drug of choice against many Gram-positive bacterial infections. "
2.	Linezolid (Zyvox)FDA Link 05/01/2011 - "Taking into account the potential bias in comparing heterogeneous clinical trials and reports, the available literature data suggest that linezolid is a safe and effective agent for the treatment of serious Gram-positive bacterial infections in neonates and children. " 05/01/2013 - "Conclusions : Linezolid is effective and safe for the elderly with gram-positive bacterial infections. " 02/01/2023 - "We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial infections. " 04/10/2022 - "In this study, we screened fresh flowers (Lilium spp.) collected from planting bases, market and florists in Guangzhou China aiming to investigate the prevalence of AMR genes, particularly cfr, optrA and poxtA mediating resistance to linezolid, a first-line drug for the treatment of different Gram-positive bacterial infections. " 03/01/2014 - "This study aimed to evaluate the efficacy and safety of linezolid in treating Gram-positive bacterial infection in the elderly from January 2010 to December 2012. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 04/21/2023 - "Drug resistance, dormant persister cells, and biofilm formation are the key challenges affecting the efficacy of antibiotics against Gram-positive bacterial infections. " 01/28/2023 - "Studies reporting data on single-patient-level outcomes related to a specific antibiotic treatment for multidrug resistant (MDR) Gram-positive bacterial infection in children were included. " 05/20/2016 - "The studies reported here show that the lead clinical IDR, SGX94, has broad-spectrum activity against Gram-negative and Gram-positive bacterial infections caused by intracellular or extracellular bacteria and also complements the actions of standard of care antibiotics. " 01/01/2009 - "These in vitro results should be supported by in vivo studies which will guide the use of antibiotic combinations especially in the treatment of multi-resistant gram-positive bacterial infections." 06/28/2023 - "Gram-positive bacterial infections are among the most serious diseases related with high mortality rates and huge healthcare costs especially with the rise of antibiotic-resistant strains that limits treatment options. "
4.	TeicoplaninIBA 01/01/1991 - "[Clinical effectiveness of teicoplanin in the treatment of Gram-positive bacterial infections in children]." 12/01/1990 - "Treatment of bone, joint, and vascular-access-associated gram-positive bacterial infections with teicoplanin." 05/01/1988 - "Teicoplanin--a new agent for gram-positive bacterial infections." 08/01/2007 - "The authors assessed the relationship between total and free concentrations of teicoplanin in serum samples obtained from patients receiving teicoplanin therapy for Gram-positive bacterial infections. " 01/01/1988 - "Teicoplanin, a new antibiotic effective against gram-positive bacterial infections of the skin and soft tissues."
5.	GlycopeptidesIBA 12/03/2022 - "Gram-negative bacteria possess intrinsic resistance to glycopeptide antibiotics so these important antibacterial medications are only suitable for the treatment of Gram-positive bacterial infections. " 01/01/2022 - "Glycopeptides, a class of cell wall biosynthesis inhibitors, have been the antibiotics of choice against drug-resistant Gram-positive bacterial infections. " 01/01/2021 - "To compare between current evidence of novel glycopeptides against vancomycin for the treatment of gram-positive bacterial infections. " 01/01/2021 - "Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis." 04/01/2012 - "Glycopeptide antibiotics are clinically important medicines to treat serious Gram-positive bacterial infections. "
6.	Proteins (Proteins, Gene)FDA Link 01/01/2020 - "Improved understanding of the role of CWA proteins in niche- or host-specificity will allow the design of new therapeutic approaches which target key host-pathogen interactions underpinning Gram-positive bacterial infections." 01/01/2017 - "When comparing the frequencies of antigen-specific memory B-cells analyzed in over 20 screening campaigns, we found a strong correlation of the presence of anti-TIM-3 memory B-cells with memory B-cells expressing mAbs against three disease-associated antigens: (i) bacterial DNABII proteins that are a marker for Gram negative and Gram positive bacterial infections, (ii) hemagglutinin (HA) of influenza virus and (iii) the extracellular domain of anaplastic lymphoma kinase (ALK). " 10/01/2014 - "Sortase A (srtA) is the key enzyme that anchors pre-mature cell wall-attached proteins to peptidoglycan and it can affect the correct positioning of surface proteins, as well as the course of Gram-positive bacterial infection, thereby making it a potential target in the study of virulence factors and disease control. "
7.	beta-Lactamases (beta-Lactamase)IBA 03/01/1995 - "In the cases of infections with beta-lactamase producing strains, bacteriological efficacy rates were 80.0% in cases with Gram-positive bacterial infections, 75.0% in those with Gram-negative bacterial infections, and 100% in those with anaerobic bacterial infections. " 05/01/1990 - "The present study examined the efficacy of teicoplanin, a glycopeptide antibiotic active against gram-positive bacterial infections in various animal models, in the treatment of experimental endocarditis due to a beta-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin. "
8.	Gentamicins (Gentamicin)FDA LinkGeneric 05/01/1990 - "The present study examined the efficacy of teicoplanin, a glycopeptide antibiotic active against gram-positive bacterial infections in various animal models, in the treatment of experimental endocarditis due to a beta-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin. "
9.	Oxazolidinones (2 Oxazolidone)IBA 03/01/2008 - "The oxazolidinone class of antimicrobials represents a promising advance in the fight against resistant Gram-positive bacterial infections. " 06/01/2002 - "AstraZeneca is developing AZD-2563, an oxazolidinone with a novel mechanism of action, for the potential treatment of gram-positive bacterial infections, including those caused by multidrug-resistant strains [349551], [399542]. " 08/01/2022 - "Linezolid is an oxazolidinone antimicrobial regarded as a "last resort" antimicrobial, used typically for treatment of Gram-positive bacterial infections. " 01/01/2022 - "Oxazolidinones are one of the most important antibiotics for the treatment of Gram-positive bacterial infections in humans. " 01/01/2022 - "Oxazolidinones are a class of synthetic antibacterial agents with a distinct mode of action developed for the treatment of Gram-positive bacterial infections. "
10.	LactamsIBA 01/01/2017 - "Vancomycin is a first-line treatment for β-lactam-resistant Gram-positive bacterial infections. " 01/01/2022 - "β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections. " 01/01/2019 - "Vancomycin is the first-choice antibiotic for infants with β-lactam-resistant gram-positive bacterial infection. " 01/01/2020 - "Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of HLA-B*57:01. "

Therapies and Procedures

1.	Therapeutics 11/06/2023 - "The present work demonstrated that a combination of these natural compounds could be used as an antivirulence therapy against Gram-positive bacterial infection." 01/01/2018 - "The data reported here indicated that Sarconesin could be an alternative candidate for use in therapeutics against Gram-negative and Gram-positive bacterial infections. " 04/18/2013 - "Targeting agr- and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections." 11/01/2011 - "In summary, compounds 1 and 2 are active in vitro and in vivo activity against difficult-to-treat Gram-positive bacterial infections and represent a promising new class of antibacterials for use in human therapy." 01/01/2000 - "[Prospects of development of drugs for therapy of gram-positive bacterial infections]."
2.	Injections 11/10/2015 - "These results revealed that injectable c-VANH-Lips may serve as a promising carrier for VANH to increase therapeutic efficacy on gram-positive bacterial infections and reduce nephrotoxicity, which provides significantly clinical value for long-term use of VANH." 02/01/2005 - "Theravance is developing telavancin, an injectable peptidoglycan inhibitor antibiotic for potential use in the treatment of Gram-positive bacterial infection. "
3.	Maggot Debridement Therapy 03/01/2007 - "Maggot debridement therapy (MDT) has been proven to be very effective in the treatment of gram-positive bacterial infections. "
4.	Length of Stay 05/01/2021 - "Dalbavancin Efficacy and Impact on Hospital Length-of-Stay and Treatment Costs in Different Gram-Positive Bacterial Infections." 05/01/2021 - "The study aimed to evaluate the impact of dalbavancin therapy on both hospital length-of-stay (LOS) and treatment-related costs, as well as to describe the clinical outcome, in a retrospective cohort of patients with diverse Gram-positive bacterial infections, hospitalized in different specialty Units. "
5.	Catheters 01/01/2014 - "This was in contrast to gram positive bacterial infections, which decreased over time despite having shown the highest possibility of death earlier in catheter days. " 12/01/2007 - "Continuous infusion might be an attractive option to treat tunnel Gram-positive bacterial infections when catheter removal might not be feasible or advisable." 10/01/2006 - "Since over 80% of BSI were considered catheter-related, the higher incidence of gram-positive bacterial infections was likely due to the presence of indwelling central venous catheters. " 07/25/2013 - "In microbial spectrum analysis, antimicrobial-impregnated catheters were shown to have a lower rate of Gram-positive bacterial infection, particularly the coagulase-negative Staphylococcus. " 12/01/2007 - "We treated 13 episodes of tunnel Gram-positive bacterial infection occurring in pediatric patients with cancer or serious blood disorders with 24-hr intra-catheter antibiotic continuous infusion. "