|1.||Mandelkow, Eckhard: 37 articles (08/2015 - 02/2004)|
|2.||Trojanowski, John Q: 36 articles (09/2014 - 06/2002)|
|3.||Avila, Jesús: 32 articles (01/2016 - 02/2002)|
|4.||Lee, Virginia M-Y: 32 articles (09/2014 - 06/2002)|
|5.||Novak, Michal: 28 articles (07/2015 - 01/2003)|
|6.||Mandelkow, Eva-Maria: 28 articles (01/2015 - 01/2002)|
|7.||Goedert, Michel: 28 articles (09/2014 - 10/2002)|
|8.||Binder, Lester I: 26 articles (12/2013 - 04/2002)|
|9.||Iqbal, Khalid: 23 articles (03/2014 - 02/2002)|
|10.||Kuret, Jeff: 21 articles (01/2016 - 07/2003)|
|1.||Alzheimer Disease (Alzheimer's Disease)
10/21/2015 - "Several independent studies have implicated tau protein as central to Alzheimer's disease progression and cell-to-cell pathology propagation. "
01/01/2015 - "These models are also of interest in the study of Alzheimer's disease because the microtubule-associated protein tau is hyperphosphorylated during the hibernation state known as torpor, similar to the pretangle stage of Alzheimer's disease. "
05/01/2014 - "Structural study of the microtubule-associated protein tau locus of Alzheimer's disease in Taiwan."
01/01/2013 - "We use this approach to study the lung-specific pathways used by the influenza virus, pointing to IRAK1, BHLHE40 and TOLLIP as potential regulators of influenza virus pathogenicity, and to study the signalling pathways that play a role in Alzheimer's disease, identifying a pathway involving the altered phosphorylation of the Tau protein. "
08/01/2012 - "Previous investigations showed a hyperphosphorylation of the tau protein during hibernation and aging and raised hopes that Syrian hamsters might represent a useful animal model to study pathogenetic mechanisms of Alzheimer's disease. "
01/01/2014 - "Suppression of tau protein expression has been shown to improve behavioral deficits in mouse models of tauopathies, offering an attractive therapeutic approach. "
06/01/2013 - "Previous studies identified EFhd2 associated with pathological forms of tau proteins in the tauopathy mouse model JNPL3, which expresses the human tau(P301L) mutant. "
12/14/2012 - "This study demonstrates that cells actively release Tau in the absence of disease or toxicity, and Tau release is modified by changes in the Tau protein that are associated with tauopathies."
02/01/2011 - "Because murine tau might interfere with the toxic effects of human mutant tau, we generated a model in which a pathogenic human tau protein is expressed in the absence of wild-type tau protein, with the aim of facilitating the study of the pathogenic role of the mutant tau and to reproduce more faithfully a human tauopathy. "
05/01/2010 - "To address the determinants of Tau neurotoxicity, we used Drosophila models of human tauopathies to study the microtubule-binding properties of human Tau proteins in vivo. "
|3.||Neurodegenerative Diseases (Neurodegenerative Disease)
04/01/2004 - "Hopefully, the identification of several genetic defects of the tau gene will be helpful in improving our understanding of the role of tau protein in the pathogenesis of various neurodegenerative diseases."
04/15/2015 - "Many studies have established the importance of hyperphosphorylation of the microtubule-associated protein tau in various neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. "
01/01/2014 - "A similar phenotype can be observed in various preclinical models, which have been generated to study the role of tau protein in neurodegenerative disorders. "
01/11/2013 - "Although there have been numerous studies on tau proteins and AD in various stages of neurodegenerative disease pathology, the relationship between tau and AD is not yet fully understood. "
01/01/2013 - "Illuminating the role of the microtubule-associated protein tau in neurodegenerative diseases is of increasing importance, supported by recent studies establishing novel functions of tau in synaptic signalling and cytoskeletal organization. "
10/01/2012 - "The present study was conducted to assess the relationship between CSF Aβ and tau protein levels and longitudinal measures of hippocampal structure in individuals with and without very mild dementia of the Alzheimer type. "
08/01/2008 - "The present study suggests the importance of investigating this ratio of total tau protein to phosphorylated tau protein in differentiating CJD from other dementias. "
12/01/2004 - "Adult patients with DM1 frequently develop, with aging, a focal dementia: such findings agree with recent studies documenting an abnormal tau-protein expression in the brain tissues of patients with DM1. "
04/01/1995 - "Studies on hereditary types of ATD suggest that the etiologies of ATD are heterogeneous, but the deposition of beta-protein followed by tau-protein with resulting dementia seems to be the common process of ATD. "
09/17/2014 - "We used an immunomagnetic reduction assay to measure the plasma levels of Aβ40, Aβ42, and tau proteins in 20 older control participants and 25 participants who had either mild cognitive impairment due to AD or early AD dementia. "
12/01/2006 - "When they are excessively produced and can no longer be effectively destroyed or otherwise cleared from the hypoperfused ageing brain, the Abeta42 fragments released from the active synaptic terminals of normally busy neurons (and from stressed neurons unsuccessfully trying to proliferate and producing disruptive tangles of hyperphosphorylated tau-proteins) aggregate into neuritic plaques, which activate glial cells. "
12/01/2015 - "The increment of iPLA2 activity may reduce the production of beta-amyloid plaques, whereas the phosphorylation of GSK3B inactivates the enzyme, reducing thus the phosphorylation of tau protein. "
09/01/2015 - "Tau pathology consisted of intracellular accumulation of neurofibrillary tangles of hyperphosphorilated tau protein and accumulation of Aβ-peptide's deposits, defined as neuritic plaques, are the principal neuropathological diagnostic criteria of the disease. "
02/05/2015 - "The accumulation of amyloid plaques, deposition of phosphorylated-tau protein, and number of astrocytes in the brain were assessed histopathologically at 3, 6, 9, and 12-15 months of age. "
01/01/2015 - "Accumulated amyloid deposits, Tau protein hyperphosphorylation and Tau intracellular redistribution emerged rapidly in DS neurons within 45 days but not in normal embryonic stem cell-derived neurons. "
|1.||Amyloid (Amyloid Fibrils)
|3.||Apolipoproteins E (ApoE)
|5.||Protein Isoforms (Isoforms)
|9.||Adrenocorticotropic Hormone (ACTH)
|2.||Drug Therapy (Chemotherapy)