HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
Also Known As:
Cyclo-Oxygenase Inhibitors; Inhibitors, Cyclo-Oxygenase; Inhibitors, Cyclooxygenase; Inhibitors, Prostaglandin Synthase; Inhibitors, Prostaglandin-Endoperoxide Synthase; Antagonist, Prostaglandin Synthesis; Antagonists, Prostaglandin Synthesis; Cyclo Oxygenase Inhibitor; Cyclo Oxygenase Inhibitors; Inhibitor, Cyclo-Oxygenase; Inhibitor, Cyclooxygenase; Inhibitor, Prostaglandin Synthase; Inhibitors, Cyclo Oxygenase; Inhibitors, Prostaglandin Endoperoxide Synthase; Synthase Inhibitor, Prostaglandin; Synthesis Antagonist, Prostaglandin; Cyclo-Oxygenase Inhibitor; Cyclooxygenase Inhibitor; Prostaglandin Endoperoxide Synthase Inhibitor; Prostaglandin Endoperoxide Synthase Inhibitors; Prostaglandin Synthase Inhibitor; Prostaglandin Synthase Inhibitors; Prostaglandin Synthesis Antagonist; Prostaglandin Synthesis Antagonists
Networked: 1024 relevant articles (61 outcomes, 92 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ohlsson, Arne: 6 articles (11/2020 - 03/2013)
2. Shah, Sachin S: 6 articles (11/2020 - 03/2013)
3. Knapp, Deborah W: 5 articles (04/2016 - 01/2002)
4. Eisenach, James C: 5 articles (01/2015 - 09/2003)
5. Eling, Thomas E: 5 articles (12/2009 - 07/2003)
6. Geisslinger, Gerd: 4 articles (03/2014 - 05/2003)
7. Li, Wei: 4 articles (03/2013 - 01/2009)
8. Mohammed, Sulma I: 4 articles (04/2007 - 01/2002)
9. Walia, Rajneesh: 3 articles (11/2020 - 02/2015)
10. Yaksh, Tony L: 3 articles (01/2020 - 10/2004)

Related Diseases

1. Inflammation (Inflammations)
2. Pain (Aches)
3. Neoplasms (Cancer)
4. Carcinogenesis
07/01/2008 - "Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts."
03/15/2004 - "These results indicate that the cyclooxygenase inhibitor sulindac is effective in reducing UVB-induced events relevant to carcinogenesis and that this category of topically applied or orally administered drugs may prove to be effective chemopreventive agents for reducing the risk of photocarcinogenesis in human populations."
04/01/1992 - "By contrast, the previously reported suppression of the promotional phase of colonic carcinogenesis in rats by the delayed introduction of cyclooxygenase inhibitors may not be linked to inhibition of local colonic prostanoid production, since (i) inhibition of colonic prostanoid synthesis by ASA did not mimic this antipromotional effect, and (ii) the doses of non-steroidal anti-inflammatory drugs employed in some earlier studies may not significantly inhibit colonic prostanoid synthesis."
04/01/2005 - "[NSAID, type 2 cyclo-oxygenase inhibitors and pancreatic carcinogenesis]."
10/17/2002 - "Cyclooxygenase-2-mediated stromal-epithelial cell signalling during the early stages of intestinal tumorigenesis provides a novel target for chemoprevention of colorectal cancer (and other gastro-intestinal epithelial malignancies, which arise on a background of chronic inflammation, such as gastric cancer) and may explain the discrepancy between the concentrations of cyclooxygenase inhibitors required to produce anti-neoplastic effects in vitro and in vivo."
5. Asthma (Bronchial Asthma)

Related Drugs and Biologics

1. Indomethacin (Indometacin)
2. Aspirin (Acetylsalicylic Acid)
3. Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
4. Prostaglandins
5. Ibuprofen (Motrin)
6. Lipoxygenase Inhibitors
7. Piroxicam (Feldene)
8. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
9. Lipoxygenase (Lipoxygenase-1)
10. Opioid Analgesics (Opioids)

Related Therapies and Procedures

1. Therapeutics
2. Chemoprevention
3. Drug Therapy (Chemotherapy)
4. Immunotherapy
5. Oral Administration