CD8 Antigens

Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. T8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.

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Networked: 99 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cansler, Meghan E: 3 articles (01/2017 - 09/2007)
2.	Lewinsohn, David M: 3 articles (01/2017 - 09/2007)
3.	Lewinsohn, Deborah A: 3 articles (01/2017 - 09/2007)
4.	Null, Megan D: 3 articles (01/2017 - 09/2007)
5.	Swarbrick, Gwendolyn M: 3 articles (01/2017 - 09/2007)
6.	McWeeney, Shannon: 2 articles (01/2017 - 01/2013)
7.	Sherman, David R: 2 articles (01/2017 - 01/2013)
8.	Huang, Gang: 1 article (02/2021)
9.	Li, Lianghua: 1 article (02/2021)
10.	Liu, Jianjun: 1 article (02/2021)

Related Diseases

1.	Infections 12/01/2003 - "Adoptive transfer of IBV-infection-induced alphabeta T cells bearing CD8 antigen protected chicks from challenge infection. " 12/13/2002 - "In order to induce effective CTL responses against most infections and tumours, DCs must prime both CD4(+) and CD8(+) antigen-specific T cells. " 03/30/2000 - "These results indicated that alphabeta T lymphocytes bearing CD8(+) antigens are critical in protecting chicks from IBV infection." 03/30/2000 - "Adoptive transfer of infectious bronchitis virus primed alphabeta T cells bearing CD8 antigen protects chicks from acute infection." 03/01/1997 - "Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8+CD95+, CD8+CD38+, and CD4+CD95+ T cells are markers for HIV-1 infection and clinical status."
2.	Neoplasms (Cancer) 01/01/2022 - "We found that the activities of multiple steps of the anticancer immune response cycle, such as the release of cancer cell antigens, CD8 T cell recruitment, and NK cell recruitment, were significantly higher in the high-risk score group than in the low-risk score group. " 02/09/2021 - "Furthermore, in the humanized PBMC-NSG and HSC-NPG mouse models, 68Ga-NOTA-SNA006a accumulated in both CD8+ tumors and specific tissues such as liver, spleen and lung where human CD8 antigen was overexpressed or CD8+ T cells located during immunoPET imaging. " 09/01/2005 - "Spontaneous apoptosis of circulating CD8(+) antigen-responding effector T-cells contributes to rapid lymphocyte turnover and depressed absolute numbers of T-cell subsets observed in patients with cancer. " 07/01/2003 - "CD2, CD3, CD4, and CD8 antigens were detected in none of 447 cases of nonhematopoietic tumors. " 07/01/1999 - "We studied the reactivity of an antibody to the CD8 antigen (C8/144B), recognizing K15, on 66 cutaneous tumors with known or alleged pilar differentiation, in order to assess its usefulness in the diagnosis of this group of tumors. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/01/1990 - "In the present study, we examined a lymphoma derived from a child lymphoblastic lymphoma bearing CD1, CD4, and CD8 antigens and established in nude mice. " 04/01/1997 - "The immature cells of T-cell acute lymphocytic leukemia and lymphoblastic lymphoma represented a dominant uniform population of cells demonstrating strong staining with both the CD4 and CD8 antigens. " 06/01/1992 - "Twenty-four patients expressed CD4 and/or CD8 antigens on their blast cells, designated T acute lymphoblastic leukemia (T-ALL). " 09/01/1988 - "Serum concentrations of CD8 antigen were measured at diagnosis with an enzyme-linked immunoassay in children with acute lymphoblastic leukemia (n = 344) or non-Hodgkin's lymphoma (n = 65). "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 03/01/2007 - "The results of our immunohistological studies indicate that immunostaining with p53, Bcl-2, and CD8 antigens could be useful in differentiating APF from closely related inflammatory conditions such as psoriasis and cutaneous LE. " 01/01/1990 - "Elevated levels of soluble CD8 antigen in sera of patients with psoriasis--a possible sign of suppressor/cytotoxic T-cell activation." 06/01/1991 - "Determination of released CD4 and CD8 antigens in the suction-blister fluid and horny-tissue extract in patients with psoriasis." 06/01/1991 - "The amounts of soluble CD4 and CD8 antigens were measured in suction-blister fluid and extracts of horny tissue in patients with psoriasis. "
5.	Inflammation (Inflammations) 08/17/2000 - "Here we show that progression of pancreatic islet inflammation to overt diabetes in nonobese diabetic (NOD) mice is driven by the 'avidity maturation' of a prevailing, pancreatic beta-cell-specific T-lymphocyte population carrying the CD8 antigen. " 10/01/2003 - "In our present study we analyzed the spatiotemporal expression pattern of the CD8 antigen in various rat EAE models characterized by a different extent of inflammation, demyelination, and axonal injury. " 10/01/2001 - "Increased numbers of beta2-MG, HLA-DR, CD3, CD4 and CD8 antigen positive cells are presented in the monkey livers after adenovirus-mediated gene therapy and induce mild to moderate transient hepatic inflammation. "

Related Drugs and Biologics

1.	Antigens
2.	Interleukin-2 Receptors (IL 2 Receptor)
3.	Antibodies
4.	T-Cell Antigen Receptors (T-Cell Receptor)
5.	Interferon-gamma (Interferon, gamma)
6.	Granzymes (Granzyme)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Interleukin-2 (IL2)
9.	Interleukin-2 Receptor beta Subunit
10.	Neopterin

Related Therapies and Procedures

1.	Therapeutics
2.	Splenectomy
3.	Ligation
4.	Immunotherapy