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Human Platelet Antigens

Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy.
Also Known As:
Antigens, Human Platelet; Alloantigen, Platelet; Alloantigens, Platelet; Antigen, Human Platelet; Antigen, Platelet-Specific; Antigens, Platelet Specific; Platelet Antigen, Human; Platelet Antigens, Human; Platelet Specific Antigen; Platelet Specific Antigens; Antigens, Platelet-Specific; Human Platelet Antigen; Platelet Alloantigen; Platelet Alloantigens; Platelet-Specific Antigen; Platelet-Specific Antigens
Networked: 286 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Santoso, Sentot: 13 articles (01/2020 - 03/2005)
2. Porcelijn, Leendert: 8 articles (11/2021 - 01/2009)
3. Bein, Gregor: 8 articles (01/2020 - 05/2009)
4. de Haas, Masja: 6 articles (11/2021 - 01/2009)
5. Husebekk, Anne: 6 articles (01/2021 - 01/2016)
6. Lucas, Geoff: 6 articles (01/2019 - 01/2004)
7. Oepkes, Dick: 5 articles (11/2021 - 01/2015)
8. van der Schoot, C Ellen: 5 articles (11/2021 - 01/2014)
9. Poles, Anthony: 5 articles (01/2021 - 09/2013)
10. Sachs, Ulrich J: 5 articles (11/2019 - 07/2013)

Related Diseases

1. Transfusion Reaction
2. Graft vs Host Disease (Graft-Versus-Host Disease)
05/01/2004 - "Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft-versus-host disease."
09/01/1999 - "Incompatibility for CD31 and human platelet antigens and acute graft-versus-host disease after bone marrow transplantation."
02/01/2005 - "Mismatches between donor and recipient for human platelet antigens (HPAs) may also affect the success of transplantation owing to serving as minor histocompatibility antigens and therefore rendering recipients at risk for graft-versus-host disease (GVHD) or graft rejection and inhibition of thrombopoiesis attributed to platelet (PLT) antibodies. "
10/01/2003 - "Mismatches between donor and recipient for human platelet antigens (HPA) may affect the success of transplantation due to: (a) serving as minor histocompa-tibility antigens and therefore render recipients at risk for graft-versus-host disease (GvHD), (b) inhibition of thrombopoiesis due to platelet antibodies. "
12/01/2023 - " reduction and JAK inhibitors in the treatment of PTR are worth exploring.AbbreviationsPLT: platelets; PTR: platelet transfusion refractoriness; HSCT: hematopoietic stem cell transplantation; OR: odds ratio; HR: hazard ratio; CI: confidence interval; IQR: interquartile range; SD: standard deviation; HLA: human leukocyte antigen; HPA: human platelet antigen; OS: overall survival; RFS: relapse free survival; PI: post-transfusion increment; PPR: percentage platelet recovery; CCI: corrected count increment; ICU: intensive care unit; AA: aplastic anemia; MDS: myelodysplastic syndrome; AML: acute myeloid leukemia; ALL: acute lymphocytic leukemia; CML: chronic myeloid leukemia; CMML: chronic myelomonocytic leukemia; MPN: myeloproliferative neoplasm; SI: splenic irradiation; Abs: antibodies; CR: complete remission; DAC: decitabine; GVHD: graft-versus-host disease; BM: bone marrow; PB: peripheral blood."
3. Neoplasms (Cancer)
4. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
5. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Related Drugs and Biologics

1. Antibodies
2. Antigens
3. HLA Antigens (Human Leukocyte Antigens)
4. Decitabine
5. Janus Kinase Inhibitors
6. Isoantibodies
7. Immunoglobulin G (IgG)
8. Glycoproteins (Glycoprotein)
9. Platelet Membrane Glycoproteins
10. Isoantigens (Alloantigen)

Related Therapies and Procedures

1. Platelet Transfusion (Blood Platelet Transfusions)
2. Hematopoietic Stem Cell Transplantation
3. Blood Transfusion (Blood Transfusions)
4. Therapeutics
5. Transplantation