Feline Infectious Peritonitis

Common coronavirus infection of cats caused by the feline infectious peritonitis virus (CORONAVIRUS, FELINE). The disease is characterized by a long incubation period, fever, depression, loss of appetite, wasting, and progressive abdominal enlargement. Infection of cells of the monocyte-macrophage lineage appears to be essential in FIP pathogenesis.

Also Known As:

Networked: 181 relevant articles (15 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Inflammation (Inflammations)
3.	Vasculitis (Vasculitides)
4.	Neoplasms (Cancer)
5.	Ascites

Experts

1.	Hartmann, Katrin: 12 articles (01/2022 - 01/2007)
2.	Matiasek, Kaspar: 10 articles (01/2022 - 01/2007)
3.	Paltrinieri, Saverio: 10 articles (06/2015 - 01/2003)
4.	Felten, Sandra: 7 articles (01/2022 - 06/2017)
5.	Giordano, Alessia: 7 articles (06/2015 - 01/2003)
6.	Takano, Tomomi: 6 articles (10/2020 - 01/2007)
7.	Pedersen, Niels C: 6 articles (07/2020 - 08/2014)
8.	Hohdatsu, Tsutomu: 6 articles (05/2020 - 12/2003)
9.	Paltrinieri, S: 5 articles (06/2021 - 09/2001)
10.	Fischer, Andrea: 5 articles (01/2021 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Feline Infectious Peritonitis:

1.	GS-441524IBA 01/01/2022 - "This is the first report on a clinical follow-up and postmortem examination of a cat that had been cured of feline infectious peritonitis (FIP) with ocular manifestation by successful treatment with an oral multicomponent drug containing GS-441524. " 09/01/2023 - "GS-441524 has been successfully used to treat feline infectious peritonitis (FIP) in cats. " 01/01/2022 - "As previously demonstrated by our research group, the oral multicomponent drug Xraphconn® containing GS-441524 was effective at curing otherwise fatal feline infectious peritonitis (FIP) in 18 feline coronavirus (FCoV)-infected cats. " 11/05/2021 - "Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524." 01/01/2023 - "Long-term follow-up of cats in complete remission after treatment of feline infectious peritonitis with oral GS-441524."
2.	VaccinesIBA 04/01/2004 - "Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis." 12/01/1990 - "Protection against feline infectious peritonitis by intranasal inoculation of a temperature-sensitive FIPV vaccine." 07/01/1997 - "A modified live virus vaccine against feline infectious peritonitis (FIP) was evaluated in a double blind, placebo-controlled field trial in two high-risk populations. " 10/01/2022 - "Feline infectious peritonitis (FIP), caused by genetic mutants of feline enteric coronavirus known as FIPV, is a highly fatal disease of cats with no currently available vaccine or US Food and Drug Administration-approved cure. " 07/01/1997 - "Placebo-controlled evaluation of a modified life virus vaccine against feline infectious peritonitis: safety and efficacy under field conditions."
3.	NucleosidesIBA 09/01/2023 - "Nucleoside analog GS-441524 is effective in treating cats with feline infectious peritonitis (FIP). " 01/01/2019 - "The aim of this study was to determine the safety and efficacy of the nucleoside analog GS-441524 for cats suffering from various forms of naturally acquired feline infectious peritonitis (FIP). " 01/01/2019 - "Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis." 06/01/2018 - "The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies." 01/01/2023 - "Nucleoside analogs GS-441524 and remdesivir (GS-5734) are effective in treating cats with feline infectious peritonitis (FIP). "
4.	Antiviral Agents (Antivirals)IBA 03/23/2015 - "Virulent biotypes of feline coronavirus (FCoV), commonly referred to as feline infectious peritonitis virus (FIPV), can result in the development of feline infectious peritonitis (FIP), a typically fatal immune mediated disease for which there is currently no effective antiviral treatment. " 07/30/2021 - "Unlicensed GS-441524-Like Antiviral Therapy Can Be Effective for at-Home Treatment of Feline Infectious Peritonitis." 07/30/2021 - "The goal of this study was to formally evaluate the administration of unlicensed, crowd-sourced antiviral GS-441524-like therapy for cats suspected to have feline infectious peritonitis (FIP), a previously fatal disease. " 10/20/2022 - "Feline infectious peritonitis (FIP) is a complex and historically fatal disease, though recent advances in antiviral therapy have uncovered potential treatments. " 06/02/2011 - "Infection with virulent biotypes of feline coronavirus (FCoV) can result in the development of feline infectious peritonitis (FIP), a typically fatal immune mediated disease for which there is currently no effective antiviral treatment. "
5.	GC376IBA 01/01/2022 - "An Mpro inhibitor, GC376, has been shown to treat feline infectious peritonitis (FIP), a fatal infection in cats caused by internal mutations in the feline enteric coronavirus (FECV). " 01/01/2018 - "Objectives The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). " 01/01/2020 - "Here we show that a clinically approved anti-HCV drug, Boceprevir, and a pre-clinical inhibitor against feline infectious peritonitis (corona) virus (FIPV), GC376, both efficaciously inhibit SARS-CoV-2 in Vero cells by targeting Mpro. " 01/01/2021 - "Protease inhibitor GC376 for COVID-19: Lessons learned from feline infectious peritonitis." 01/01/2022 - "Here, we report the development of the enzyme and cell-based assays for the 3CLpro of GI.1c/RHDV, recombinant GI.3P-GI.2 (RHDV2/b), and GII.1/European brown hare syndrome virus (EBHSV) as well as the identification of potent lagovirus 3CLpro inhibitors, including GC376, a protease inhibitor being developed for feline infectious peritonitis. "
6.	Protease Inhibitors (Protease Inhibitor)IBA 01/01/2018 - "Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis." 01/01/2018 - "Objectives The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). " 10/01/2019 - "Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor." 01/01/2021 - "Protease inhibitor GC376 for COVID-19: Lessons learned from feline infectious peritonitis." 01/01/2022 - "Here, we report the development of the enzyme and cell-based assays for the 3CLpro of GI.1c/RHDV, recombinant GI.3P-GI.2 (RHDV2/b), and GII.1/European brown hare syndrome virus (EBHSV) as well as the identification of potent lagovirus 3CLpro inhibitors, including GC376, a protease inhibitor being developed for feline infectious peritonitis. "
7.	AntigensIBA 12/11/2018 - "The present study describes the association between inflammatory cell types and feline infectious peritonitis virus (FIPV) antigen in the brain of 4 cats diagnosed as feline infectious peritonitis (FIP). " 06/01/2017 - "Objectives The aim of the study was to evaluate whether an ante-mortem diagnosis of central nervous system (CNS) feline infectious peritonitis (FIP) is possible via immunocytochemical staining (ICC) of feline coronavirus antigen (FCoV) within macrophages of cerebrospinal fluid (CSF). " 11/01/2013 - "Diagnostic utility of a direct immunofluorescence test to detect feline coronavirus antigen in macrophages in effusive feline infectious peritonitis." 11/01/2007 - "Feline infectious peritonitis was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. " 12/01/2005 - "The detection of typical lesions and feline coronavirus (FCoV) antigen in tissues is the only conclusive method for making a diagnosis of feline infectious peritonitis (FIP). "
8.	Proteins (Proteins, Gene)FDA Link 01/01/2020 - "Prevalence and mutation analysis of the spike protein in feline enteric coronavirus and feline infectious peritonitis detected in household and shelter cats in western Canada." 01/01/2019 - "The amino acid substitutions M1058L and S1060A in the spike protein of feline coronavirus (FCoV) have been postulated to be responsible for the development of the pathogenic feline infectious peritonitis virus (FIPV), which causes feline infectious peritonitis (FIP). " 10/10/2014 - "Mutations of 3c and spike protein genes correlate with the occurrence of feline infectious peritonitis." 12/01/2013 - "Although the mutation of FCoV accessory gene 3c has been suggested to be related to the occurrence of feline infectious peritonitis (FIP), how the 3C protein is involved in this phenomenon remains unknown. " 04/01/2004 - "Tissue distribution of a feline AGP related protein (fAGPrP) in cats with feline infectious peritonitis (FIP)."
9.	remdesivirIBA 11/01/2022 - "Successful treatment of a South African cat with effusive feline infectious peritonitis with remdesivir." 01/01/2023 - "Efficacy of Oral Remdesivir Compared to GS-441524 for Treatment of Cats with Naturally Occurring Effusive Feline Infectious Peritonitis: A Blinded, Non-Inferiority Study." 09/01/2023 - "Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered GS-441524." 09/01/2023 - "Thirty-two cats with effusive or non-effusive feline infectious peritonitis treated with a combination of remdesivir and GS-441524." 01/01/2023 - "Retrospective study and outcome of 307 cats with feline infectious peritonitis treated with legally sourced veterinary compounded preparations of remdesivir and GS-441524 (2020-2022)."
10.	NucleotidesIBA 01/01/2014 - "While parent virus FIPV DF-2 developed feline infectious peritonitis in all the infected cats, its recombinant virus PBFIPV-DF-2, differing only in seven nucleotides, proved to be surprisingly low virulent, although caused an acute febrile episode similarly to the original FIPV DF-2. " 01/01/2022 - "The main objectives of this study were to investigate the efficacy of the nucleotide analog GS-441524 in combination with the 3C-like protease inhibitor GC376 for the treatment of naturally aquired feline infectious peritonitis (FIP) and to test whether their combination shortens the dosing period and improves the cure rate. "

Therapies and Procedures

1.	Therapeutics 11/01/2007 - "There is no therapy with proven efficacy to treat cats with feline infectious peritonitis (FIP). " 08/01/2020 - "Potential therapy of feline infectious peritonitis." 08/01/2014 - "This review is concerned with what has been learned about feline infectious peritonitis (FIP) diagnostics and therapeutics since the publication of an extensive overview of literature covering the period 1963-2009. " 08/01/2014 - "An update on feline infectious peritonitis: diagnostics and therapeutics." 12/16/2014 - "Feline infectious peritonitis (FIP), caused by feline coronavirus (FCoV) infection, is a highly lethal disease without effective therapy and prevention. "
2.	Oral Administration 06/08/2020 - "Pharmacokinetic Profile of Oral Administration of Mefloquine to Clinically Normal Cats: A Preliminary In-Vivo Study of a Potential Treatment for Feline Infectious Peritonitis (FIP)."
3.	Aftercare (After-Treatment) 01/01/2023 - "Long-term follow-up of cats in complete remission after treatment of feline infectious peritonitis with oral GS-441524."