HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Proto-Oncogene Proteins c-fos (FRAs)

Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
Also Known As:
FRAs; Antigens, Fos-Related; Proto-Oncogene Products c-fos; Proto-Oncogene Proteins fos; p55 c-fos; Antigen, Fos-Related; Fos Related Antigen; Fos Related Antigens; Protein, c-fos; Protein, fos Proto-Oncogene; Proto Oncogene Products c fos; Proto Oncogene Proteins c fos; Proto Oncogene Proteins fos; Proto-Oncogene Protein, fos; c fos Protein; c fos Proteins; fos Proto Oncogene Protein; fos Proto Oncogene Proteins; p55 c fos; Fos B Protein; Fos-Related Antigen; Fos-Related Antigens; c-fos Protein; c-fos Proteins; fos Proto-Oncogene Protein; fos Proto-Oncogene Proteins; p55(c-fos)
Networked: 329 relevant articles (3 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Szyndler, Janusz: 4 articles (10/2009 - 11/2004)
2. Krisztin-Péva, Beáta: 3 articles (01/2019 - 08/2004)
3. Mihály, András: 3 articles (01/2019 - 08/2004)
4. Cao, Jun-Li: 3 articles (01/2018 - 05/2010)
5. Kim, Min Sun: 3 articles (03/2014 - 09/2008)
6. Park, Byung Rim: 3 articles (03/2014 - 09/2008)
7. Bidziński, Andrzej: 3 articles (10/2009 - 11/2004)
8. Lehner, Małgorzata: 3 articles (10/2009 - 11/2004)
9. Maciejak, Piotr: 3 articles (10/2009 - 11/2004)
10. Płaźnik, Adam: 3 articles (10/2009 - 11/2004)

Related Diseases

1. Rupture
2. Bone Diseases (Bone Disease)
3. Congenital Abnormalities (Deformity)
4. Seizures (Absence Seizure)
5. Schizophrenia (Dementia Praecox)
01/01/2015 - "In conclusion, the results of this study suggest that FOS is among the candidate genes of schizophrenia and that changes in the expression of c-Fos protein may contribute to molecular pathomechanisms of schizophrenia-related alterations in synaptic plasticity. "
01/01/2023 - "Using prepulse inhibition (PPI) of the acoustic startle, which is impaired in schizophrenia,we aimed to investigate:i) the existence of a direct and potentially inhibitory neural pathway between the inferior colliculus (IC) and the pedunculopontine tegmental nucleus (PPTg) involved in the mediation of PPI responses by a neural tract tracing procedure;ii) if the microinjection of the 5-HT2A receptors agonist DOI in IC would activate neurons in this structure and in the PPTg by a c-Fos protein immunohistochemistry study;iii) whether the deficits in PPI responses, observed after the administration of DOI in the IC, could be prevented by the concomitant microinjection of the GABAA receptor antagonist bicuculline in the PPTg.Male"
09/28/2001 - "Immunohistochemistry of c-Fos protein was performed to study changes in neuronal activity in discrete brain areas of mice repeatedly treated with phencyclidine (PCP) showing enhancement of immobility in the forced swimming test, this behavioral change being considered as avolition, which is one of negative symptoms of schizophrenia. "
10/01/2019 - "Here, we examined the effect of the atypical antipsychotic Clozapine (Clz) (20 mg/kg/day for 3 weeks) on the neuronal activation pattern of c-Fos protein expression in stress-relevant brain subregions of adult male Wistar rats exposed to chronic social isolation (CSIS: 3 weeks), an animal model of depression and schizophrenia, and controls. "
01/01/2015 - "Also, comparative determination of the blood levels of c-Fos protein in schizophrenia patients and controls was performed using the enzyme-linked immunosorbent assay. "

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Proto-Oncogene Proteins c-fos (FRAs)
3. Messenger RNA (mRNA)
4. Transcription Factor AP-1 (Transcription Factor AP 1)
5. Kainic Acid (Kainate)
6. Carrageenan
7. Advanced Oxidation Protein Products (AOPP)
8. Neuropeptide Y
9. Somatostatin (Somatotropin Release-Inhibiting Factor)
10. Pilocarpine (Ocusert)

Related Therapies and Procedures

1. Electroacupuncture
2. Therapeutics
3. Intraventricular Injections
4. Spinal Injections
5. Injections