|4.||Cardiac Arrhythmias (Arrythmia)
|1.||Bardy, Gust H: 22 articles (03/2015 - 08/2002)|
|2.||Sotoodehnia, Nona: 18 articles (07/2015 - 10/2005)|
|3.||Lee, Kerry L: 18 articles (03/2015 - 07/2006)|
|4.||Mark, Daniel B: 18 articles (03/2015 - 07/2006)|
|5.||Al-Khatib, Sana M: 17 articles (12/2015 - 07/2006)|
|6.||Albert, Christine M: 16 articles (06/2015 - 06/2002)|
|7.||Moss, Arthur J: 16 articles (03/2015 - 04/2004)|
|8.||Siscovick, David S: 15 articles (10/2014 - 10/2005)|
|9.||Zareba, Wojciech: 15 articles (05/2014 - 05/2006)|
|10.||Ackerman, Michael J: 14 articles (07/2015 - 03/2002)|
|1.||Amiodarone (Amiodarona)FDA LinkGeneric
12/01/2010 - "In patients with increased risk for sudden cardiac death, e.g., with severely depressed left ventricular function, amiodarone is a highly effective and safe antiarrhythmic drug. "
08/01/1995 - "Left ventricular ejection fraction < or = 0.27 and amiodarone treatment were related to greater cardiac mortality and increased risk of sudden cardiac death, whereas beta-blockade was associated with improved survival. "
11/04/1997 - "Some randomized clinical trials of amiodarone therapy to prevent sudden cardiac death have had positive results and others have had negative results, but all were relatively small. "
05/01/2009 - "Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized controlled trials."
12/01/2002 - "The conflicting results of GESICA and CHF-STAT studies do not support a strategy of "prophylactic" amiodarone therapy in patients with DCM in order to prevent sudden cardiac death. "
|2.||Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
07/01/2003 - "Furthermore, the recent GISSI-Prevention study of 11 324 patients showed a marked decrease in risk of sudden cardiac death as well as a reduction in all-cause mortality in the group taking a highly purified form of omega-3 fatty acids, despite the use of other secondary prevention drugs, including beta-blockers and lipid-lowering therapy. "
09/13/2007 - "This assertion is substantiated by statistical data on sudden cardiac death and by the results of interventional studies on omega-3 fatty acids. "
01/01/2006 - "Based on the present knowledge about the relationship between blood levels of omega-3 fatty acids and sudden cardiac death obtained from studies of 14,000 individuals, a subject with an index below 50 should be advised to increase his/her intake of omega-3 fatty acids. "
07/01/2005 - "The data suggest that the protection offered by n-3 PUFA against sudden cardiac death observed in previous studies is mediated by a direct antiarrhythmic effect of n-3 PUFA."
06/01/2000 - "The recent GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico)-Prevention study of 11,324 patients showed a 45% decrease in risk of sudden cardiac death and a 20% reduction in all-cause mortality in the group taking 850 mg/d of omega-3 fatty acids. "
09/01/1984 - "The development of four new antiarrhythmic drugs offers promise for the treatment of patients who survive an episode of sudden cardiac death. "
11/01/1985 - "[Efficacy of anti-arrhythmia agents for the prevention of cardiac sudden death]."
09/01/2002 - "Overview of randomized trials of antiarrhythmic drugs and devices for the prevention of sudden cardiac death."
04/15/1997 - "During recent years a number of controlled randomised trials have been published showing no or a harmful effect of antiarrhythmic drugs on the prognoses of patients at risk of sudden cardiac death. "
11/26/1993 - "Several studies have demonstrated that class I antiarrhythmic drugs do not reduce, and may increase, sudden cardiac death mortality and total cardiac mortality. "
|4.||Fatty Acids (Saturated Fatty Acids)IBA
06/01/2011 - "In conclusion, the method described could be suitable for monitoring EPA, DHA and AA in clinical studies that may aid in achieving optimal concentrations of these fatty acids in patients who could be at risk of sudden cardiac death."
06/01/2003 - "A brief review of three clinical trials that suggest that these PUFAs prevent sudden cardiac death is also included in order to emphasize the potential importance of these fatty acids in human nutrition. "
10/01/2014 - "Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest."
01/01/2013 - "We therefore undertook to identify such risk factors in a nationally representative cohort and were able to include baseline levels of blood fatty acids, some of which influence arrhythmogenicity and sudden cardiac death risk. "
07/01/2010 - "Little is known of the associations of endogenous fatty acids with sudden cardiac arrest (SCA). "
|5.||Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/01/2010 - "Studies suggest that marine n-3 polyunsaturated fatty acids (PUFA) offer some protection against sudden cardiac death (SCD). "
09/01/2013 - "Omega-3 polyunsaturated fatty acids for patients at risk of sudden cardiac death and ventricular arrhythmias: trial sequential analysis."
06/01/2012 - "Recent clinical studies that evaluated the effects of supplemental omega-3 polyunsaturated fatty acids (n-3 PUFAs) on sudden cardiac death have yielded conflicting results. "
09/01/2007 - "There were also observational and clinical trials that more specifically showed that the reduction in cardiovascular deaths from eating fish was largely the result of the prevention of sudden cardiac death by n-3 polyunsaturated fatty acids in fish oil. "
12/01/2006 - "There were also observational and clinical trials, which more specifically showed that the reduction in cardiovascular deaths from eating fish were largely the result of n-3 polyunsaturated fatty acids in fish oil for the prevention of sudden cardiac death (SCD). "
01/01/1991 - "Thus, calcium antagonists that exert direct myocardial actions may prove to be particularly effective in the prevention of sudden cardiac death in patients. "
12/01/2011 - "In this study, we tested whether FKBP12.6-deficient mice that display hypertrophic hearts can develop exercise-induced cardiac sudden death and whether the hypertrophic heart is a direct consequence of abnormal calcium handling in mutant cardiomyocytes. "
01/01/2006 - "Over the past 5 years, various clinical studies have confirmed the predictive value of the coronary calcium score for both soft (revascularization, MI) and hard (MI and sudden cardiac death) events incrementally and independently of traditional coronary risk factors identified by the Framingham Heart Study. "
09/11/2012 - "CPVT is a familial arrhythmogenic syndrome characterized by abnormal calcium (Ca(2+)) handling, ventricular arrhythmias, and sudden cardiac death. "
08/01/2008 - "As will be discussed, these changes promote the prolongation of the action potential, the enhancement of spatio-temporal gradients of repolarization, the formation of calcium-mediated triggers and conduction abnormalities, all of which combine to form an electrophysiological substrate that is ripe for the genesis of lethal arrhythmias and sudden cardiac death."
|7.||Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/01/2004 - "Secondary prevention of sudden cardiac death after cardiac events is based on betablockers, ACE inhibitors and antilipemic therapy. "
01/01/2003 - "Most anti-hypertensive therapies, such as the beta blockers or ACE inhibitors, by slowing or interrupting the progression towards atrial and ventricular remodelling might exert some anti-arrhythmic effect, thus reducing the risk of sudden cardiac death in these patients."
12/05/2000 - "Although beta-blockers, angiotensin-converting enzyme inhibitors, and revascularization play a role in prevention of sudden cardiac death, the development and subsequent refinement of the implantable cardioverter-defibrillator has made the most important contribution to its management. "
01/01/2014 - "Indeed, major randomized clinical trials suggest that suboptimal use of fundamental drugs, such as ACE inhibitors (ACE-i) and beta-blockers, may affect ICD shock-free survival, sudden cardiac death (SCD), and overall mortality. "
01/01/1996 - "The prolongation of life in heart failure patients treated with ACE-inhibitors might either derive from retarding the progression of heart failure (CONCENSUS I) or from reducing sudden cardiac death (VHeFT II-trial). "
05/01/2008 - "Plasma remnant-like lipoprotein particles or LDL-C as major pathologic factors in sudden cardiac death cases."
03/01/2001 - "[Association of plasma triglyceride-rich lipoprotein remnants with sudden cardiac death]."
03/01/2005 - "Benefits include lower risk of primary cardiac arrest; reduced cardiovascular mortality, particularly sudden cardiac death; reduced triglyceride levels; increased high-density lipoprotein levels; improved endothelial function; reduced platelet aggregability; and lower blood pressure. "
10/01/2007 - "We have previously reported that plasma levels of remnant-like lipoprotein particles (RLP) significantly increased in sudden cardiac death cases with and without coronary atherosclerosis. "
02/01/1999 - "Association of plasma triglyceride-rich lipoprotein remnants with coronary atherosclerosis in cases of sudden cardiac death."
01/01/2014 - "Recent large trials with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the cardiovascular field did not demonstrate a beneficial effect in terms of reductions of clinical endpoints like total mortality, sudden cardiac arrest or other major adverse cardiac events. "
03/01/2008 - "These and other data strengthen the concept that a low omega-3 index is a risk factor for sudden cardiac death, as a tool to assess the status of a person in terms of eicosapentaenoic acid plus docosahexaenoic acid, and as a means to monitor therapy with eicosapentaenoic acid plus docosahexaenoic acid. "
03/01/2008 - "In a recently published intervention study with eicosapentaenoic acid in patients at high cardiovascular risk in Japan, sudden cardiac death was rare. "
03/01/2008 - "More importantly, in systematic reviews, it has been demonstrated that eicosapentaenoic acid plus docosahexaenoic acid reduce sudden cardiac death by 50%. "
11/01/2009 - "The n-3 index (erythrocyte eicosapentaenoic acid plus docosahexaenoic acid) may be considered as a potential risk marker for coronary heart disease mortality, especially sudden cardiac death. "
|10.||Sotalol (Sotalol Hydrochloride)FDA LinkGeneric
01/01/2000 - "Sotalol had no influence at all on sudden cardiac death, while all the other beta-blockers referred to above have a very marked effect on sudden cardiac death, in fact more marked than on overall mortality. "
11/01/1996 - "Four patients had sudden cardiac death; three of these deaths occurred within the first month, and the last episode of sudden death occurred after 8 years of sotalol therapy. "
07/07/1994 - "As compared with other antiarrhythmic agents, sotalol prevents recurrences of arrhythmia in a higher proportion of patients, particularly among those presenting with ventricular tachycardia and aborted sudden cardiac death. "
08/01/1993 - "A study comparing amiodarone and sotalol in high-risk patients for sudden cardiac death is also needed. "
01/01/1992 - "The known pharmacological profiles and limited controlled clinical studies make amiodarone and sotalol promising candidates for drugs that may improve survival of patients at risk for sudden cardiac death."
|1.||Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
07/01/2006 - "Implantable cardioverter defibrillators (ICDs) have been proven to be highly efficacious in protecting very high-risk cardiac patients from sudden cardiac death and hence enhancing their overall survival. "
11/01/2000 - "The implantable cardioverter defibrillator (ICD) is highly effective in the treatment of ventricular arrhythmias (VA) responsible for sudden cardiac death. "
01/01/1997 - "The implantable cardioverter-defibrillator (ICD) has dramatically improved survival rates following sudden cardiac death episodes. "
01/01/1993 - "Implantable cardioverter defibrillators have dramatically improved survival rates for patients at risk of sudden cardiac death, but the occurrence of inappropriate shocks remains an unresolved problem. "
04/01/2011 - "Randomized controlled trials have proven the efficacy of implantable cardioverter/defibrillators (ICDs) to prevent sudden cardiac death (SCD) in primary prevention. "
06/01/1989 - "Thus both subendocardial resection and defibrillator implantation are highly effective in preventing sudden cardiac death. "
12/01/1994 - "The cardioverter defibrillator therapy has proven to be effective in preventing sudden cardiac death. "
08/01/2004 - "Implantable cardiac defibrillators (ICDs) are beneficial for certain patient groups with a history of serious, recurrent ventricular dysrhythmias, with a high risk of sudden cardiac death. "
12/01/2008 - "Surgery and, more recently, implantable cardiac defibrillators have had an impact on sudden cardiac death rates, with improved short- and medium-term survival. "
05/01/2011 - "Many RCTs have confirmed that defibrillators are effective in the prevention of sudden cardiac death (SCD): they lower the risk of SCD by 20% to 30% in primary prevention and by 20% to 40% in secondary prevention. "
|3.||Cardiopulmonary Resuscitation (CPR)
08/01/2010 - "These data demonstrate that immediate care with improved means to circulate blood during CPR significantly reduces hospital mortality from inhospital sudden cardiac arrest."
10/10/1994 - "Selective use of CPR in the hospital and community training in the use of these new adjunctive techniques should have the greatest impact on improved survival after sudden cardiac arrest."
05/01/2006 - "The efficacy of cardiopulmonary resuscitation (CPR) is vital for saving lives of victims with sudden cardiac arrest. "
12/01/2003 - "Dispatcher-assisted telephone cardiopulmonary resuscitation (CPR) instruction can increase the proportion of sudden cardiac arrest victims who receive bystander CPR and has been associated with improved survival. "
01/01/2014 - "Studies suggest that education to increase bystander CPR and implementation of school AEDs and other public access defibrillation programs improve the survival of youth experiencing sudden cardiac arrest to 74% when optimal programs are in place. "
11/01/2005 - "There has been considerable interest in analysis of the surface electrocardiogram (ECG) in VF centred on attempts to understand the pathophysiological processes occurring in sudden cardiac death, predicting the efficacy of therapy, and guiding the use of alternative or adjunct therapies to improve resuscitation success rates. "
01/01/2004 - "There has been considerable interest in analysis of the surface electrocardiogram (ECG) in VF centred on attempts to understand the pathophysiological processes occurring in sudden cardiac death, predicting the efficacy of therapy, and guiding the use of alternative or adjunct therapies to improve resuscitation success rates. "
12/01/2006 - "This study examined a population of nonselected patients presenting to a community hospital following successful resuscitation of sudden cardiac death. "
09/02/2006 - "The aims of the present study were to analyze the prognosis after resuscitation from out-of-hospital sudden cardiac death in patients admitted to the coronary care unit, and to identify the predictor variables of morbi-mortality. "
04/01/1998 - "To study the circumstances and medical profile of out-of-hospital sudden cardiac arrest (SCA) patients in whom resuscitation was attempted by the ambulance service, and to identify causes of SCA in survivors and factors that influence resuscitation success rate. "
|5.||Transplantation (Transplant Recipients)
05/01/2009 - "This study sought to determine whether ICDs are effective in preventing sudden cardiac death in high-risk heart transplant recipients. "
09/18/2001 - "The present study supports the use of ICDs as a bridge to transplantation in patients who are at risk of sudden cardiac death. "
02/17/2015 - "During follow-up (median, 6.6 years), 10 patients died of a cardiac cause, 11 patients underwent transplantation, and another 11 patients suffered an aborted sudden cardiac death. "
03/01/2013 - "Intramyocardial transplantation of human ATMSC based 3D-MTs was successful in eight animals (88.8%) while one pig (without MI) died during the electromechanical mapping due to sudden cardiac-arrest. "
08/01/2008 - "In conclusion, mutations in taffazin impair mitochondrial respiratory chain complexes, which may results in the acute metabolic decompensation and sudden death; cardiac transplantation is the only possibility at the present time."