|4.||Chronic Hepatitis B
|1.||Zhang, Jun: 19 articles (08/2015 - 02/2003)|
|2.||Okamoto, Hiroaki: 16 articles (09/2015 - 02/2003)|
|3.||Aggarwal, Rakesh: 10 articles (11/2015 - 07/2002)|
|4.||Purcell, Robert H: 10 articles (07/2015 - 01/2002)|
|5.||Xia, Ning-Shao: 9 articles (08/2015 - 03/2004)|
|6.||Takahashi, Masaharu: 9 articles (08/2015 - 02/2003)|
|7.||Xia, Ningshao: 8 articles (04/2015 - 02/2003)|
|8.||Izopet, J: 7 articles (09/2015 - 05/2007)|
|9.||Izopet, Jacques: 7 articles (09/2015 - 05/2006)|
|10.||Wu, Ting: 7 articles (08/2015 - 01/2008)|
01/01/2009 - "Several antigens derived from hepatitis E virus (HEV) genotype 1 strains have shown immunogenicity and efficacy against hepatitis E in primates and humans. "
01/01/2015 - "In this study, we used a combination of various physiochemical and immunochemical methods to analyze hepatitis E vaccine antigen quality attributes after recovery from adjuvants. "
08/01/2004 - "Several studies for the development of an effective vaccine against hepatitis E are in progress and the best candidate at present for a hepatitis E vaccine is a recombinant HEV capsid antigen expressed in insect cells from a baculovirus vector. "
06/01/1998 - "The present study compares serologic results with different antigens and tests developed in two laboratories for their ability to diagnose hepatitis E and measure antibody prevalence in a high risk population in Saudi Arabia. "
03/01/1994 - "Immunohistochemical study of hepatitis E virus antigen in liver tissues from patients with hepatitis E."
|2.||Hepatitis B e AntigensIBA
03/01/2015 - "Patients were classified into six groups: immunotolerance, immunoclearance, low replicative, negative hepatitis e (HBeAg) phases, liver cirrhosis, and hepatocellular carcinoma. "
11/15/1990 - "The proliferative response of PBMC to hepatitis B virus (HBV) envelope, core, and e Ag was analyzed prospectively in 21 patients with acute self-limited HBV infection and compared with the response of patients with chronic HBV infection and different levels of HBV replication (i.e., hepatitis e Ag (HBeAg)- or anti-HBe-positive) and liver damage (i.e., chronic active hepatitis or chronic asymptomatic carriers). "
03/01/2015 - "Quantifying hepatitis 'e' antigen during the first 2 years of TDF treatment is a practical tool in predicting long-term HBeAg loss. "
05/01/2011 - "BALB/c mice were immunized with Hepatitis e antigen (HBeAg) and spleen and lymph nodes of mice were cryopreserved for 3 to 10 months. "
06/01/2008 - "Of the 43 patients, 21 were hepatitis e antigen (HBeAg) (+) (Gr.1) and 22 HBeAg (-) (Gr.2) at presentation. "
|3.||RNA (Ribonucleic Acid)IBA
04/01/2012 - "Detection of negative-sense RNA in packaged hepatitis E virions by use of an improved strand-specific reverse transcription-PCR method."
11/01/2015 - "In clinical samples from hepatitis E patients, the HEV-Ag and HEV RNA positivity rates were 55.6% (65/117) and 60.7% (71/117) in sera and 76.7% (56/73) and 84.9% (62/73) in stools, and the concordance of these two markers was 77.8% in sera and 80.8% in stools. "
08/01/2015 - "HEV RNA of genotype 3 was detected in his serum, and he was diagnosed with acute hepatitis E. "
02/01/2015 - "Hepatitis E RNA was identified in 17/57 (29·8%) seropositive farms. "
09/01/2013 - "First, RNA quantification of hepatitis E diluted standards of 3a and 3b genotypes were performed. "
03/05/2015 - "Immunization with this hepatitis E vaccine induced antibodies against HEV and provided protection against hepatitis E for up to 4.5 years. "
01/01/2002 - "The study demonstrated the inadequacy of urine specimens for detection of hepatitis E antibodies."
04/01/1995 - "Since levels of hepatitis E antibodies may quickly wane, studies to directly measure the incidence of seroconversion are planned to determine the intensity of transmission in this area."
07/01/2015 - "Declining prevalence of hepatitis E antibodies among Danish blood donors."
03/05/2015 - "Of the participants who were assessed for immunogenicity and were seronegative at baseline, 87% of those who received three doses of the hepatitis E vaccine maintained antibodies against HEV for at least 4.5 years; HEV antibody titers developed in 9% in the control group. "
03/01/2011 - "Hepatitis E vaccines have been evaluated in phase III studies. "
01/01/2011 - "Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. "
01/01/2004 - "[Studies on etiology and vaccines of hepatitis E]."
12/01/2012 - "Two experimental vaccines against hepatitis E have been developed; one of them has been recently licensed but is not yet widely available. "
10/01/2012 - "Two genetically engineered hepatitis E vaccines are currently in development, showing more than 95% protective efficacy. "
|6.||DNA (Deoxyribonucleic Acid)IBA
08/01/2004 - "In this article, the recent advances of hepatitis E and the development of vaccine research for HEV including recombinant protein vaccine, DNA vaccine and the recombinant hepatitis E virus like particles (rHEV VLPs) are briefly reviewed."
12/01/2002 - ": The feasibility of DNA vaccination against hepatitis E in non-human primates has not been evaluated. "
03/01/2001 - "In response to a small antigenic challenge delivered as DNA, possibly less than delivered by a human infective dose of virus, mice with memory were able to generate high levels of antibody in less time than the usual incubation period of hepatitis E. "
11/01/1998 - "DNA fragments complementary to hepatitis E Burma strain ORF2 and ORF3 obtained by oligonucleotide synthesis were cloned in expressing bacterial system. "
12/01/2006 - "To compare the influence of hepatitis E virus (HEV) infection on the replication of hepatitis B virus (HBV) by observing clinical features, the relationship between the number of HBV DNA copies in serum, the degree of hepatic function impairments and prognosis of chronic hepatitis B patients with hepatitis E superinfection. "
|7.||Immunoglobulin M (IgM)IBA
12/01/2013 - "We conclude that these anti-HEV IgM assays performed well in immunosuppressed subjects with acute hepatitis E and can be used as first line virological tools. "
11/01/2012 - "Icteric acute hepatitis E with no response of immunoglobulin M class anti-hepatitis E virus antibody."
03/01/2012 - "Of these, 24 patients were found to be positive for anti-HEV IgM and diagnosed with acute Hepatitis E. "
10/01/2011 - "Diagnosis of hepatitis E using IgM anti-HEV should be made with caution."
06/01/2010 - "One HEV strain (FJ763142) was identified from an acute viral hepatitis E patient with IgM anti-HEV in Korea. "
|8.||Capsid Proteins (Capsid Protein)IBA
01/01/2011 - "A vaccine that contains a recombinant truncated capsid protein of HEV produced in an insect cell system has already been shown to be effective in preventing hepatitis E, at least in young men. "
10/01/2001 - "A candidate vaccine consisting of baculovirus-expressed recombinant capsid protein protected macaques from hepatitis E--it passed phase I clinical trials and is currently scheduled for phase II/III clinical trials."
09/28/2012 - "Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs."
03/01/2008 - "No effective treatment exists for hepatitis E; however, a vaccine using a baculovirus-expressed recombinant hepatitis E capsid protein was recently studied in Nepal. "
10/01/2006 - "Comparative sequence analysis found identities of 82 to 92% and 78 to 80% between the helicase and capsid protein genes, respectively, of the virus detected in this outbreak and those of other avian hepatitis E virus isolates, suggesting extensive genetic heterogeneity in avian hepatitis E viruses in Ontario flocks."
|9.||Ribavirin (Virazole)FDA LinkGeneric
09/01/2011 - "Ribavirin therapy could be an effective treatment of severe acute hepatitis E."
10/01/2014 - "Long-term hepatitis E viral load kinetics in an immunocompromised patient treated with ribavirin."
08/01/2014 - "Severe acute hepatitis E in an HIV infected patient: Successful treatment with ribavirin."
06/01/2012 - "Acute hepatitis E does not require any treatment but in chronically infected patients, a sustained viral response and finally a definitive viral clearance has been observed after a three-month course of low-dose ribavirin (600 to 800 mg/day). "
09/01/2011 - "Treatment of severe acute hepatitis E by ribavirin."
|10.||Alanine Transaminase (SGPT)IBA
08/01/2012 - "The results showed that the hepatitis e antibody-negativity was not associated with good prognosis, while less necrotic activity, and alanine aminotransferase levels were not correlated with the severity of the disease."
09/01/1995 - "By comparison with non-ABCDE, cases with hepatitis E were more frequently icteric and exhibited higher alanine aminotransferase levels (92.2% vs. 45.1%, 770 iu/l vs 377 iu/l, respectively, p < 0.005). "
08/14/2009 - "The patient had abdominal pain, dark urine, and laboratory results consistent with hepatitis (e.g., serum alanine aminotransferase of 898 IU/L [normal: 10-55 IU/L]). "
01/01/1995 - "Specific markers of viral hepatitis C were detected in 15.9%, of hepatitis B in 12.0%, of hepatitis D in 2.0%, of hepatitis E in 8.0%, of hepatitis A in 2.0% of sera with high SGPT levels. "
11/01/2015 - "They reported a novel enveloped virus with a circular double-stranded DNA genome (tentatively named KIs virus, KIs-V) (Satoh et al., 2011) occurring in 36 out of the 100 hepatitis E (HEV) antibody-positive donors with elevated alanine aminotransferase (ALT) levels (>60 IU/L). "
09/01/2013 - "Epidemiology and management of chronic hepatitis E infection in solid organ transplantation: a comprehensive literature review."
02/01/2015 - "During the study period, four cases of self-limited acute hepatitis E after travel to endemic areas were recorded, as well as five cases of HEV infection after solid organ transplantation. "
12/01/2014 - "It is proposed that consumption of HEV-contaminated undercooked meat is a main source for HEV infections in developed countries--which might also account for some hepatitis E cases after organ transplantation. "
|2.||Transplantation (Transplant Recipients)
04/01/2013 - "This study aimed to identify and characterize hepatitis E cases in renal transplant recipients in Brazil. "
06/01/2014 - "Hepatitis E in liver transplant recipients in the Rhône-Alpes region in France."
01/01/2014 - "Hepatitis E-associated encephalopathy in a renal transplant recipient."
08/01/2011 - "Seroprevalence of hepatitis E among Iranian renal transplant recipients."
08/01/2012 - "This review will examine recent studies describing the impact of adenovirus, rhinovirus, hepatitis E and norovirus in the course of solid organ and stem cell transplant recipients, as well as their epidemiology and implications for infection prevention and control. "
|3.||Renal Dialysis (Hemodialysis)
05/01/2015 - "The present study aimed to determine the prevalence rate of anti-hepatitis E antibody in hemodialysis patients in Hamadan, Iran. "
05/01/2015 - "Available studies reporting on the seroprevalence of hepatitis E in hemodialysis patients in Iran, an endemic region for the disease, are sparse. "
05/01/2015 - "Previous studies have documented a high prevalence of hepatitis E among patients undergoing maintenance hemodialysis. "
09/01/2015 - "Anti-Hepatitis E Antibody in Hemodialysis Patients in Isfahan, Iran: Prevalence and Risk Factors."
05/01/2015 - "Seroprevalence of hepatitis e among hemodialysis patients: a report from hamadan, iran."
10/01/2015 - "Taming the Beast: Tailored Therapy for Hepatitis E in Organ Transplant Recipients."
12/01/2014 - "The impact of hepatitis E in the liver transplant setting."
06/27/2014 - "To examine the incidence of hepatitis E (HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit. "
02/01/2013 - "Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in southwest England: a case-control study."
09/01/2012 - "Hepatitis E virus quasispecies and the outcome of acute hepatitis E in solid-organ transplant patients."
02/01/2014 - "We report here four cases of fulminant and sub-fulminant hepatitis E proposed for liver transplantation in Marseille University hospitals between July 2006 and March 2010. "
06/01/2013 - "Two cases of hepatitis E that were assisted in our Unit of Hepatology and Liver Transplantation are described in this article. "
01/01/2015 - "Prevalence and clinical consequences of Hepatitis E in patients who underwent liver transplantation for chronic Hepatitis C in the United States."
02/01/2014 - "In Europe, autochthonous hepatitis E associated with fulminant hepatic failure and leading to liver transplantation has been exceptionally reported. "
07/01/2001 - "Hepatitis E-associated subacute liver failure: a rare indication for liver transplantation."