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Synapsins (Synapsin I)

A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
Also Known As:
Synapsin I; Synapsin; Synapsin II; Synapsin III
Networked: 330 relevant articles (9 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Benfenati, Fabio: 22 articles (11/2021 - 10/2006)
2. Mishra, Ram K: 9 articles (01/2019 - 09/2002)
3. Valtorta, Flavia: 9 articles (01/2018 - 10/2006)
4. Bykhovskaia, Maria: 5 articles (02/2022 - 06/2010)
5. Rouleau, Guy A: 5 articles (11/2016 - 01/2012)
6. Etholm, Lars: 5 articles (01/2015 - 04/2009)
7. Andrade, Rodrigo: 4 articles (02/2022 - 11/2013)
8. Bellucci, Arianna: 4 articles (01/2022 - 07/2015)
9. Longhena, Francesca: 4 articles (01/2022 - 07/2015)
10. Pizzi, Marina: 4 articles (01/2022 - 07/2015)

Related Diseases

1. Brain Ischemia (Cerebral Ischemia)
11/27/2012 - "We tested this hypothesis by evaluating the motor skill relearning and the immunocontent of Synapsin-I, PSD-95 and GFAP (pre and post-synaptic elements, as well as surrounding astroglia) in sensorimotor cortex of both hemispheres 6 weeks after endothelin-1-induced focal brain ischemia in rats. "
01/01/1992 - "In a gerbil model of bilateral cerebral ischemia, immunoreaction for synapsin I was persistently preserved after seven days to two months recirculation following a brief period of global forebrain ischemia in the CA1 region of the hippocampus, where delayed neuronal death was consistently observed.(ABSTRACT TRUNCATED AT 250 WORDS)"
01/01/2021 - "Taken together, this study suggested that DOR activation-induced protective signaling pathways of PKCα-MARCKS involved in the synaptic morphology and BDNF-ERK-synapsin I in synaptic transmission may be engaged in the cognitive recovery in rats suffering from advanced cerebral ischemia."
01/16/2004 - "These results suggested that the neuronal damage and degenerations were observed as a result of GOD/reperfusion and the increase in synapsin I and its phosphorylation might play a role in modulating the release of neurotransmitters via exocytosis and in the formation of new synapses after brain ischemia."
02/05/2023 - "Furthermore,the expression of synapsin I and Neun was significantly reduced after cerebral ischemia and rhynchophylline administration ameliorated the loss of synapsin I. Rhynchophylline is a promising treatment for ischemic stroke via improving synaptic plasticity and ameliorating the sensory-motor function."
2. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
3. Ischemic Stroke
4. Cognitive Dysfunction
5. Inflammation (Inflammations)

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9. Bromodeoxyuridine (BrdU)
10. notopterol

Related Therapies and Procedures

1. Microspheres (Microsphere)
2. Transplantation
3. Intraventricular Infusions
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5. Therapeutics