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Monocrotaline

A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Also Known As:
Monocrotaline Hydrochloride (13alpha,14alpha)-Isomer; Monocrotaline, (all-xi)-Isomer; 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
Networked: 1629 relevant articles (133 outcomes, 298 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Weissmann, Norbert: 30 articles (02/2021 - 01/2004)
2. Humbert, Marc: 29 articles (01/2022 - 12/2009)
3. Seeger, Werner: 28 articles (02/2021 - 01/2004)
4. Grimminger, Friedrich: 24 articles (02/2021 - 01/2004)
5. Schermuly, Ralph T: 20 articles (02/2021 - 01/2004)
6. Wang, Jian: 17 articles (01/2022 - 01/2013)
7. Guignabert, Christophe: 16 articles (01/2022 - 05/2005)
8. Provencher, Steeve: 15 articles (01/2022 - 09/2012)
9. Belló-Klein, Adriane: 15 articles (11/2021 - 08/2008)
10. Ghofrani, Hossein Ardeschir: 15 articles (02/2021 - 04/2004)

Related Diseases

1. Pulmonary Hypertension
2. Pulmonary Arterial Hypertension
3. Hypoxia (Hypoxemia)
4. Vascular Remodeling
5. Hypertrophy

Related Drugs and Biologics

1. Sildenafil Citrate (Viagra)
2. rho-Associated Kinases
3. Proteins (Proteins, Gene)
4. Epoprostenol (Prostacyclin)
5. fasudil (AT 877)
6. Endothelin-1 (Endothelin 1)
7. Angiotensin II
8. Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
9. Simvastatin (Zocor)
10. Antioxidants

Related Therapies and Procedures

1. Therapeutics
2. Pneumonectomy (Lung Volume Reduction)
3. Transplantation
4. Oral Administration
5. Ligation