|1.||Strengert, Monika: 1 article (07/2012)|
|2.||Verkade, Paul: 1 article (07/2012)|
|3.||Alvarez, Luis A J: 1 article (07/2012)|
|4.||Knaus, Ulla G: 1 article (07/2012)|
|5.||Alemka, Abofu: 1 article (07/2012)|
|6.||Mantell, Judith: 1 article (07/2012)|
|7.||Corcionivoschi, Nicolae: 1 article (07/2012)|
|8.||Bourke, Billy: 1 article (07/2012)|
|9.||Sharp, Thomas H: 1 article (07/2012)|
|10.||Bootsma, Hester J: 1 article (08/2011)|
03/01/2011 - "Although the use of TNF-α in the treatment of cancer is restricted due to its non-specific cytotoxicity and narrow range of applications to different cancers in clinical trials, we investigated a safe anti-cancer drug by the use of engineered bacterial capsule harboring TNF-α. "
03/01/2011 - "Engineered bacterial capsule invaded tumor cells, released TNF-α, and induced apoptosis of tumor cells without apparent side effects. "
03/01/2011 - "This bacterial capsule induced a tumor-suppressive environment through the activation of natural killer cells. "
03/01/2011 - "In a murine melanoma model, the bacterial capsule of TNF-α significantly inhibited tumor growth by 80-100% and prolonged the survival of the mice. "
03/01/2011 - "The engineered bacterial capsule was designed to target cancer cells, promote a tumor-suppressive environment, and increase the efficacy of existing cancer treatments, including chemotherapy, radiotherapy, and cell therapy. "
|2.||Communicable Diseases (Infectious Diseases)
11/01/1993 - "The areas advanced by studies of the pneumococcus include an understanding of the concept of pathogenesis of infectious disease; the development of Gram's stain for identification of bacteria in specimens from patients; the elucidation of the role of the bacterial capsule in resistance to phagocytosis by cells of the host's immune system; the demonstration that molecules other than proteins are capable of eliciting the host's humoral immune responses and later, by extension, that isolated bacterial exopolysaccharides can be used safely and effectively as vaccines in humans; the documentation of the efficacy of penicillin; the collection of conclusive evidence that DNA encodes genetic information; and the investigation of putative proteinaceous virulence factors."
11/01/2000 - "Role of bacterial capsule in local and systemic inflammatory responses of mice during pulmonary infection with Klebsiella pneumoniae."
07/19/2012 - "We report that ROS generated by epithelial NADPH oxidases (Nox1/Duox2) during Campylobacter jejuni infection impair bacterial capsule formation and virulence by altering bacterial signal transduction. "
09/01/1999 - "Among these are the development of Gram's stain for identification of bacteria in patient specimens, investigations of the role of the bacterial capsule in resistance to phagocytosis by cells of the host immune system, demonstration that molecules other than proteins are capable of eliciting host humoral immune responses, development of safe and effective vaccines composed of isolated bacterial exopolysaccharides, confirmation of the efficacy of penicillin against serious gram-positive infections, and perhaps most important confirmation that DNA alone encodes genetic information."
|4.||Dehydration (Water Stress)
11/01/2000 - "The role of bacterial capsule in inflammatory responses in experimentally induced pneumonia caused by Klebsiella pneumoniae was evaluated by comparing the host immunological responses in mice infected with capsulate strain DT-S and non-capsulate mutant strain DT-X. Anaesthetised ICR mice were infected intranasally with inocula of strain DT-S or DT-X. Mice infected with strain DT-X survived significantly longer than those inoculated with strain DT-S. "
09/26/2003 - "The role of the bacterial capsule and O-antigen moiety of lipopolysaccharide in the pathogenesis of Gram-negative pneumonia was assessed. "
|2.||Proteins (Proteins, Gene)
|4.||DNA (Deoxyribonucleic Acid)
|6.||Virulence Factors (Pathogenicity Factors)
|7.||Immunoglobulin M (IgM)
|9.||Complement System Proteins (Complement)
|10.||Lowicryl 4KM resin
|1.||Tissue Therapy (Cell Therapy)
|3.||Drug Therapy (Chemotherapy)