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Cerebral Amyloid Angiopathy (Congophilic Angiopathy)

A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
Also Known As:
Congophilic Angiopathy; Angiopathy, Cerebral Amyloid; Angiopathy, Congophilic; Cerebral Amyloid Angiopathies; Congophilic Angiopathies; Amyloid Angiopathy, Cerebral; Sporadic Cerebral Amyloid Angiopathy
Networked: 794 relevant articles (7 outcomes, 45 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Amyloid Plaque
3. Hemorrhage
4. Dementia (Dementias)
5. Cerebral Hemorrhage

Experts

1. Greenberg, Steven M: 46 articles (11/2015 - 01/2002)
2. Frosch, Matthew P: 17 articles (11/2015 - 02/2004)
3. Werring, David J: 17 articles (08/2015 - 12/2010)
4. Rosand, Jonathan: 17 articles (07/2015 - 11/2004)
5. Holtzman, David M: 16 articles (06/2015 - 08/2003)
6. Love, Seth: 15 articles (04/2015 - 08/2003)
7. Van Nostrand, William E: 15 articles (06/2014 - 11/2002)
8. Viswanathan, Anand: 14 articles (07/2015 - 11/2008)
9. Verbeek, Marcel M: 14 articles (04/2010 - 10/2002)
10. Charidimou, Andreas: 13 articles (08/2015 - 08/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebral Amyloid Angiopathy:
1. Amyloid (Amyloid Fibrils)IBA
2. Amyloid beta-PeptidesIBA
3. Prealbumin (Transthyretin)IBA
4. Transforming Growth Factor beta (TGF-beta)IBA
5. Sirolimus (Rapamycin)FDA Link
6. Biological Markers (Surrogate Marker)IBA
7. glucuronyl glucosamine glycan sulfate (Vessel)IBA
8. ApolipoproteinsIBA
9. Cystatin CIBA
10. Apolipoproteins E (ApoE)IBA

Therapies and Procedures

1. Immunotherapy
2. Liver Transplantation
3. Neurosurgical Procedures
4. Immunomodulation
5. Transplants (Transplant)