|1.||Alzheimer Disease (Alzheimer's Disease)
|1.||Greenberg, Steven M: 46 articles (11/2015 - 01/2002)|
|2.||Frosch, Matthew P: 17 articles (11/2015 - 02/2004)|
|3.||Werring, David J: 17 articles (08/2015 - 12/2010)|
|4.||Rosand, Jonathan: 17 articles (07/2015 - 11/2004)|
|5.||Holtzman, David M: 16 articles (06/2015 - 08/2003)|
|6.||Love, Seth: 15 articles (04/2015 - 08/2003)|
|7.||Van Nostrand, William E: 15 articles (06/2014 - 11/2002)|
|8.||Viswanathan, Anand: 14 articles (07/2015 - 11/2008)|
|9.||Verbeek, Marcel M: 14 articles (04/2010 - 10/2002)|
|10.||Charidimou, Andreas: 13 articles (08/2015 - 08/2011)|
|1.||Amyloid (Amyloid Fibrils)IBA
01/01/2014 - "The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy."
01/27/2009 - "Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy."
12/01/2015 - "In this study, we investigated the effect of consumption of EVOO-enriched diet on amyloid- and tau-related pathological alterations that are associated with the progression of AD and cerebral amyloid angiopathy (CAA) in TgSwDI mice. "
07/01/2009 - "Vascular beta-amyloid deposition, also known as cerebral amyloid angiopathy, is associated with vascular dysfunction in animal and human studies. "
12/10/2008 - "Several studies have examined young Tg2576 mice expressing mutant amyloid precursor protein (APP) and having elevated levels of soluble Abeta but no cerebral amyloid angiopathy (CAA). "
02/21/2007 - "Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging."
01/01/2015 - "Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. "
08/01/2009 - "Cerebral amyloid angiopathy is caused by deposition of the amyloid beta protein in the cerebral vasculature. "
06/01/2008 - "Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid beta-protein (A beta) within cerebral vessels. "
04/01/2006 - "Pathological measures of amyloid beta protein (Abeta), as plaque Abeta40 and Abeta42(3) load and degree of cerebral amyloid angiopathy were made by image analysis or semiquantitative rating, respectively. "
01/08/2008 - "Liver transplantation was effective for CNS manifestations of cerebral amyloid angiopathy associated with amyloidogenic transthyretin Tyr114Cys."
01/08/2008 - "Effect of liver transplantation on transthyretin Tyr114Cys-related cerebral amyloid angiopathy."
07/01/2013 - "[Cerebral amyloid angiopathy with familial transthyretin-derived oculoleptomeningeal amyloidosis]."
05/01/2011 - "Clinicians should be aware that cerebral amyloid angiopathy should be considered in patients with unexplained recurrent subarachnoid bleeding, even in cases without familial clustering or transthyretin variant."
01/01/1991 - "Transthyretin-type cerebral amyloid angiopathy in type I familial amyloid polyneuropathy."
|4.||Transforming Growth Factor beta (TGF-beta)IBA
04/01/2000 - "Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy."
02/01/2007 - "Increased levels of TGFbeta in Alzheimer disease (AD) are associated with perivascular deposition of extracellular matrix, which may impair clearance of beta-amyloid and contribute to the development of cerebral amyloid angiopathy. "
|5.||Sirolimus (Rapamycin)FDA Link
09/01/2013 - "Here we demonstrate that chronic reduction of TOR activity by rapamycin treatment started after disease onset restored cerebral blood flow (CBF) and brain vascular density, reduced cerebral amyloid angiopathy and microhemorrhages, decreased amyloid burden, and improved cognitive function in symptomatic hAPP (AD) mice. "
|6.||Biological Markers (Surrogate Marker)IBA
06/01/2014 - "Developing biomarkers for cerebral amyloid angiopathy trials: do potential disease phenotypes hold promise? "
06/01/2014 - "Developing biomarkers for cerebral amyloid angiopathy trials: do potential disease phenotypes hold promise?"
07/01/2001 - "This analysis suggests that radiographic detection of small hemorrhages may be an efficient surrogate endpoint for pilot trials of promising therapeutic approaches to cerebral amyloid angiopathy."
09/01/2015 - "Cerebrospinal Fluid Biomarkers in Dementia Patients with Cerebral Amyloid Angiopathy."
09/01/2015 - "To study the changes of biomarkers in cerebrospinal fluid (CSF) in cerebral amyloid angiopathy (CAA) dementia and Alzheimer(')s disease. "
|7.||glucuronyl glucosamine glycan sulfate (Vessel)IBA
01/01/2015 - "Our study does not support a direct relation between cerebral microbleeds and cerebral amyloid angiopathy burden at the neuropathological level, raising intriguing questions on the potential pathophysiological mechanisms of cerebral microbleeds in the context of cerebral amyloid angiopathy or other small vessel disease pathology."
04/01/2015 - "Although severe small vessel disease or cerebral amyloid angiopathy may contribute in some cases, abnormal vascular contractility mediated by EDN1 is likely to be a more important overall contributor. "
01/01/2015 - "Cerebral amyloid angiopathy is a common form of small-vessel disease and an important risk factor for cognitive impairment. "
01/06/2014 - "They occur in the setting of impaired small vessel integrity, commonly due to either hypertensive vasculopathy or cerebral amyloid angiopathy. "
01/01/2014 - "The most frequent vascular pathologies in the aging brain and in AD are cerebral amyloid angiopathy and small vessel disease. "
04/01/2000 - "Apolipoprotein E, smooth muscle cells and the pathogenesis of cerebral amyloid angiopathy: the potential role of impaired cerebrovascular A beta clearance."
05/08/1998 - "High frequency of apolipoprotein E epsilon 2 allele is specific for patients with cerebral amyloid angiopathy-related haemorrhage."
06/01/1997 - "Cerebral amyloid angiopathy and apolipoprotein E: bad news for the good allele?"
05/01/1996 - "Lack of an association between apolipoprotein E epsilon 4 and cerebral amyloid angiopathy in elderly Japanese."
02/01/1996 - "Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly."
01/01/1998 - "We hypothesize that cystatin C deposition in sporadic cerebral amyloid angiopathy with cystatin C deposition (SCCAA) involves a different mechanism from that in HCHWA-I, which may be related to low CSF concentration of cystatin C without amino acid substitutions."
01/01/1998 - "To investigate the relationship between cerebral amyloid angiopathy (CAA) and cystatin C, we studied five CAA patients on whose cerebral blood vessels colocalization of cystatin C and beta-protein was recognized immunohistochemically. "
01/01/1998 - "No mutations in cystatin C gene in cerebral amyloid angiopathy with cystatin C deposition."
06/01/1997 - "The cystatin C concentration in the cerebrospinal fluid was low, which suggested the existence of cerebral amyloid angiopathy. "
08/01/1996 - "We suspected cystatin C-type cerebral amyloid angiopathy because of the low level of cystatin C in the cerebrospinal fluid. "
|10.||Apolipoproteins E (ApoE)IBA
11/01/2015 - "We conclude that both APOE ε2 and ε4 alleles are associated with more severe cerebral amyloid angiopathy, and the direct effect of ε2 is masked by the allele's negative association with comorbid Alzheimer's pathology. "
11/01/2015 - "APOE and cerebral amyloid angiopathy in community-dwelling older persons."
07/28/2015 - "APOE ε4 is associated with recurrent ICH in nonlobar brain regions, providing further evidence for its causal role in ICH unrelated to cerebral amyloid angiopathy. "
02/24/2015 - "cSS was associated with markers of cerebral amyloid angiopathy, including higher global PiB retention ratio, APOE ε2 allele presence, and a strictly lobar distribution of cerebral microbleeds. "
04/01/2014 - "Similar to cerebral amyloid angiopathy patients, microbleeds in the general population cluster and the distribution is affected by APOE genotype."
12/01/2014 - "Aβ immunotherapy for Alzheimer's disease (AD) results in the removal of Aβ plaques and increased cerebral amyloid angiopathy (CAA). "
10/01/2010 - "Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy."
01/01/2009 - "Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease."
09/01/2013 - "Whereas targeting patients at asymptomatic stages of the disease is a critical step in the goal of improving the efficacy of such antibody-based strategies, several other important factors should be considered in the development and clinical evaluation of anti-amyloid β immunotherapies, including the as yet poorly understood relationship of AD with the immune system and the importance of cerebral amyloid angiopathy. "
03/01/2009 - "Cerebral amyloid angiopathy (CAA), that is, the accumulation of amyloid in the cerebrovasculature, is increased with immunotherapy in humans with AD and in mouse models of amyloid deposition. "
01/01/1999 - "Several recent studies have suggested that neurosurgical procedures are not contraindicated in patients with cerebral amyloid angiopathy (CAA). "
10/01/1993 - "Neither plaques nor cerebral amyloid angiopathy were found in six other marmosets who were older than the injected animals, in 12 further marmosets who were slightly younger but who had been injected several years previously with brain tissue which did not contain beta-amyloid, or in 10 younger marmosets who had been subjected to various neurosurgical procedures. "