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Aflatoxin M1 (Aflatoxin M)

A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Also Known As:
Aflatoxin M; 4-Hydroxyaflatoxin B1; Aflatoxin M1, cis(+-)-Isomer; 4 Hydroxyaflatoxin B1; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-
Networked: 11 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Zollinger, Terrell: 1 article (07/2013)
2. Zhang, Jianjun: 1 article (07/2013)
3. Beshir, Safia: 1 article (07/2013)
4. Elserougy, Safaa: 1 article (07/2013)
5. Wang, Ling: 1 article (07/2013)
6. Saad-Hussein, Amal: 1 article (07/2013)
7. Ibrahim, Mohamed I M: 1 article (07/2013)
8. Moubarz, Gehan: 1 article (07/2013)
9. Peng, Kai-Yao: 1 article (05/2009)
10. Chen, Chia-Yang: 1 article (05/2009)

Related Diseases

1. Liver Neoplasms (Liver Cancer)
2. Hepatocellular Carcinoma (Hepatoma)
3. Neoplasms (Cancer)
4. Odontogenic Tumors (Dental Tissue Neoplasm)
5. Kwashiorkor

Related Drugs and Biologics

1. Aflatoxin B1 (Aflatoxin B)
2. Biological Markers (Surrogate Marker)
3. Somatomedins (Somatomedin)
4. Hepatitis B Surface Antigens (HBsAg)
5. alpha-L-Fucosidase (Fucosidase)
6. alpha-Fetoproteins (AFP)
7. Agar
8. Aflatoxins
9. methyl sterculate
10. aflatoxicol (aflatoxin R)