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Aflatoxin B1 (Aflatoxin B)

A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Also Known As:
Aflatoxin B; Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer; Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled; Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled; Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled; Aflatoxin B1, cis(+,-)-Isomer; HSDB-3453; NSC-529592; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-
Networked: 659 relevant articles (7 outcomes, 66 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Groopman, John D: 14 articles (01/2015 - 10/2002)
2. Santella, Regina M: 10 articles (09/2013 - 09/2006)
3. Ma, Yun: 9 articles (01/2014 - 10/2005)
4. Kensler, Thomas W: 8 articles (09/2013 - 02/2003)
5. Wang, Qiao: 7 articles (09/2013 - 09/2006)
6. Hainaut, Pierre: 7 articles (06/2012 - 01/2004)
7. Long, Xi-Dai: 6 articles (01/2014 - 10/2010)
8. Kew, Michael C: 6 articles (09/2013 - 12/2003)
9. Wu, Hui-Chen: 6 articles (09/2013 - 05/2007)
10. Egner, Patricia A: 6 articles (08/2012 - 02/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Hepatocellular Carcinoma (Hepatoma)
3. Liver Neoplasms (Liver Cancer)
4. Infection
5. Body Weight (Weight, Body)

Related Drugs and Biologics

1. Aflatoxins
2. oltipraz
3. Transferases
4. Proteins (Proteins, Gene)
5. Amines
6. Alkaline Phosphatase
7. Alanine (L-Alanine)
8. Coffee
9. kahweol
10. cafestol

Related Therapies and Procedures

1. Injections
2. Lasers (Laser)
3. Hepatectomy
4. Oral Administration
5. Intraperitoneal Injections