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Aphidicolin

An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
Also Known As:
Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer; ICI-69653; NSC-234714; NSC-351140; ICI 69653; ICI69653; NSC 234714; NSC 351140; NSC234714; NSC351140; 9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3alpha,4alpha,5alpha,17alpha)-
Networked: 261 relevant articles (6 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Glover, Thomas W: 4 articles (12/2013 - 10/2004)
2. Arlt, Martin F: 3 articles (10/2011 - 10/2004)
3. Dicker, David T: 3 articles (10/2007 - 01/2002)
4. El-Deiry, Wafik S: 3 articles (10/2007 - 01/2002)
5. Pommier, Yves: 3 articles (09/2007 - 05/2003)
6. Tunca, B: 3 articles (01/2002 - 05/2000)
7. Egeli, U: 3 articles (01/2002 - 05/2000)
8. Lin, Fu-Pang: 2 articles (01/2015 - 01/2008)
9. Kerem, Batsheva: 2 articles (01/2015 - 05/2007)
10. Chang, Chi-Yao: 2 articles (01/2015 - 01/2008)

Related Diseases

1. Chromosome Aberrations (Chromosome Abnormalities)
2. Neoplasms (Cancer)
3. Neuroblastoma
4. Breast Neoplasms (Breast Cancer)
5. Leukemia

Related Drugs and Biologics

1. Hydroxyurea (Hydrea)
2. Cycloheximide (Cicloheximide)
3. Liposomes (Liposome)
4. DNA (Deoxyribonucleic Acid)
5. Cisplatin (Platino)
6. Nocodazole
7. Caffeine (No Doz)
8. Bromodeoxyuridine (BrdU)
9. Carboplatin (JM8)
10. Alpha-Amanitin

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Microspheres (Microsphere)
3. Ligation