Granular Cell Tumor

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141 relevant articles (2 outcomes, 13 trials/studies) found for this Disease

Description: Unusual tumor affecting any site of the body, but most often encountered in the head and neck. Considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. It affects women more often than men. When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.

Also Known As:

Cell Myoblastoma, Granular; Cell Myoblastomas, Granular; Cell Tumor, Granular; Cell Tumors, Granular; Granular Cell Myoblastomas; Granular Cell Tumors; Myoblastomas, Granular Cell; Tumor, Granular Cell; Tumors, Granular Cell; Granular Cell Myoblastoma; Myoblastoma, Granular Cell

Relationship Network

Disease Context: Research Results

Neoplasms: 387640

Neoplasms by Histologic Type: 1

Connective and Soft Tissue Neoplasms

Muscle Tissue Neoplasms: 37

Granular Cell Tumor: 141

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Neurofibroma
4.	Neurilemmoma (Schwannoma)
5.	Gingival Neoplasms

Experts

1.	Cioccoloni, Claudia: 1 article (09/2008)
2.	Cavaliere, Antonio: 1 article (09/2008)
3.	Sidoni, Angelo: 1 article (09/2008)
4.	Colella, Renato: 1 article (09/2008)
5.	Cioccoloni, C: 1 article (09/2008)
6.	Cavaliere, A: 1 article (09/2008)
7.	Ferri, Ivana: 1 article (09/2008)
8.	Del Sordo, Rachele: 1 article (09/2008)
9.	Ferri, I: 1 article (09/2008)
10.	Colella, R: 1 article (09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Granular Cell Tumor:

1.	Inhibins (Inhibin)IBA 09/01/2001 - "This study adds the granular cell tumor to the list of inhibin-positive lesions and should prove helpful in differential diagnosis of these lesions." 07/01/2004 - "Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation." 03/01/2003 - "Reactivity of granular cell tumors for inhibin and other markers of sex cord and steroid cell differentiation." 09/01/2001 - "A Medline search of the literature revealed no case reports of granular cell tumors in any location of the body being tested for inhibin-alpha immunohistochemically, by enzyme-linked immunosorbent assay, by radioimmunoassay, or by immunoprecipitation" 09/01/2001 - "This is the first report of inhibin-alpha expression in granular cell tumors" Order ALL the reference details at left...
2.	yttrium-aluminum-garnetIBA 02/01/2002 - "Yttrium-aluminum-garnet laser therapy of esophageal granular cell tumor." 09/01/2003 - "Four bronchial granular cell tumor patients were treated locally with neodymium/yttrium-aluminum-garnet laser or electrocautery and are in complete remission or have stable residual disease" Order ALL the reference details at left...
3.	NeodymiumIBA 09/01/2003 - "Four bronchial granular cell tumor patients were treated locally with neodymium/yttrium-aluminum-garnet laser or electrocautery and are in complete remission or have stable residual disease" Order ALL the reference details at left...
4.	S100 Proteins (S 100 Protein)IBA 06/01/1989 - "Immunohistochemical study revealed S-100 protein in the component cells of the granular cell tumor, thereby supporting the proposal that this granular cell is derived from Schwann cells." 11/30/1985 - "Immunohistochemical study of S 100 protein in granular cell tumors" 02/01/2003 - "Granular cell tumors (GCTs) typically express S-100 protein, which has been used as a marker in differential diagnosis" 03/01/2000 - "The morphologic impression of granular cell tumor was also supported by the immunohistochemical demonstration of S-100 protein expression and ultrastructural findings typical of granular cell tumor" 04/01/1988 - "Nongingival granular cell tumors were universally positive for S-100 protein and failed to exhibit immunoreactivity for myogenous or histiocytic markers" Order ALL the reference details at left...
5.	AntibodiesIBA 06/30/1994 - "STUDY DESIGN: We studied 11 granular cell tumors using a panel of 20 antibodies, 13 monoclonal and 7 polyclonal" 07/01/1990 - "We examined the immunohistochemical profile of 21 granular cell tumors (GCTs) and a single clinically malignant GCT using a panel of commercially available antibodies" 12/01/1995 - "STUDY DESIGN: Four granular cell tumors and two congenital epulis were immunostained with a panel of 29 antibodies" 01/01/1987 - "A more recent study using polyclonal antibodies found negative staining for MBP in Schwann cell neoplasms including granular cell tumors" 07/01/1993 - "The results obtained by light microscopy showed that Schwann cells of nerves with Wallerian degeneration and those in traumatic neuroma, neurofibroma, and granular cell tumor exhibit intracytoplasmic immunoreactivity, which is usually intense, with KP1, Ki-M1P, and PG-M1, but normal myelinated nerves, neurogenic sarcoma, and Schwann cells in neurogenic appendicopathy do not react with these antibodies" Order ALL the reference details at left...
6.	Carcinoembryonic AntigenIBA 10/01/1982 - "Contrary to recent studies reporting the presence of carcinoembryonic antigen (CEA) in benign and malignant granular cell tumors, this case is CEA-negative" 01/01/1983 - "A series of granular cell myoblastomas (GCM) and other benign and malignant tumours of soft tissue were examined for cytoplasmic content of carcinoembryonic antigen (CEA) by the two-layer conjugated immunoperoxidase technique" 03/01/1979 - "An immunoperoxidase technique for the detection of carcinoembryonic antigen was applied to 10 cases of granular cell myoblastoma" 03/01/1979 - "Granular cell myoblastoma: positive staining for carcinoembryonic antigen." 01/01/1983 - "Granular cell myoblastoma: an immunoperoxidase study using a variety of antisera to human carcinoembryonic antigen." Order ALL the reference details at left...
7.	Phosphopyruvate Hydratase (Enolase)IBA 01/01/2001 - "Immunohistochemical staining for neuron specific enolase and S100 protein was positive, and it was suggested that the granular cell tumor was derived from Schwann cells." 05/01/2007 - "Immunohistochemical staining for S100 protein, vimentin, and neuron-specific enolase (NSE) was positive, indicating that it was a granular cell tumor" 04/01/1997 - "Positive immunostaining with protein gene product 9.5 (PGP 9.5), neurone-specific enolase (NSE) and S-100, in contrast to predominantly negative immunostaining in 12 cases of neurilemmoma of the head and neck, and a similar pattern of staining with luxol fast blue to five known neuroendocrine tumours, strongly suggests that granular cell tumors may be neuroendocrine in nature." 06/01/1986 - "The tumor cells of granular cell tumors were stained with anti-S-100 protein antibody, but not with anti-neuron-specific enolase antibody" 01/01/1994 - "Unlike those of granular cell myoblastoma, granular cells of gingival granular cell tumor do not express S-100 protein and Neuron-Specific-Enolase" Order ALL the reference details at left...
8.	Keratins (Keratin)IBA 05/01/2001 - "Pathological analysis demonstrated a granular cell tumor that was strongly positive for protein S-100 and negative for cytokeratin AE1-AE3 and CEA" 01/01/1995 - "Immunohistochemical studies demonstrated that these cells stained positive for KP1 (CD68) confirming their histiocytic nature, and negative for cytokeratin and S-100 protein excluding the diagnoses of carcinoma and granular cell tumor respectively" 10/01/1989 - "Thirty-one granular cell lesions (26 granular cell tumors [GCT] and five other granular cell lesions) from 18 different sites were evaluated immunohistochemically for keratins, vimentin, desmin, muscle actin, ACT, HLA-DR, and S-100 protein" 06/01/1986 - "Five cases of alveolar soft part sarcoma, 5 cases of granular cell tumor, and 6 cases of paraganglioma were investigated immunohistochemically to examine the expression of tissue-specific intermediate filaments (cytokeratin, vimentin, desmin, and glial fibrillary acidic protein (GFAP], actin, myoglobin, and nervous tissue markers (S-100 protein, neuron-specific enolase, and Leu-7)" 11/01/1994 - "The monoclonal antibody KP-1 that recognizes the lysosome-associated glycoprotein CD68 was used together with antibodies to other antigens (actin, glial fibrillary acidic protein, keratin, neurofilaments, chromogranin, synaptophysin, S-100 protein, HMB-45, lysozyme, and HLA-DR) in a labeled streptavidin biotin immunoperoxidase method to phenotypically characterize 27 granular cell tumors, five schwannomas, five neurofibromas, two ganglioneuromas, three ganglioneuroblastomas, five carcinoid tumors, five malignant melanomas, and five examples of histiocytosis X. The neoplastic cells in all 27 of the granular cell tumors and four of the five schwannomas strongly stained for CD68, whereas none of the neurofibromas, ganglioneuromas, ganglioneuroblastomas, or carcinoid tumors contained CD68-positive tumor cells" Order ALL the reference details at left...
9.	AntigensIBA 01/01/1984 - "In the light of recent findings concerning the presence of S-100 antigen in granular cell myoblastoma (GCM), we investigated by immunoperoxidase the presence of this antigen in a case of congenital epulis (CE)" 01/01/1983 - "Carcinoembryonic antigen like antigen in granular cell myoblastomas" 01/01/1997 - "Neuron Specific Enolase (NSE) and S-100 protein immunoperoxidase studies revealed that cells of the granular cell myoblastoma react positively for both antigens, thus confirming the neurogenic origin of this tumor." 11/01/1994 - "The monoclonal antibody KP-1 that recognizes the lysosome-associated glycoprotein CD68 was used together with antibodies to other antigens (actin, glial fibrillary acidic protein, keratin, neurofilaments, chromogranin, synaptophysin, S-100 protein, HMB-45, lysozyme, and HLA-DR) in a labeled streptavidin biotin immunoperoxidase method to phenotypically characterize 27 granular cell tumors, five schwannomas, five neurofibromas, two ganglioneuromas, three ganglioneuroblastomas, five carcinoid tumors, five malignant melanomas, and five examples of histiocytosis X. The neoplastic cells in all 27 of the granular cell tumors and four of the five schwannomas strongly stained for CD68, whereas none of the neurofibromas, ganglioneuromas, ganglioneuroblastomas, or carcinoid tumors contained CD68-positive tumor cells" Order ALL the reference details at left...
10.	Myelin P2 ProteinIBA 10/01/1985 - "The authors carried out immunohistochemical studies on 18 cases of Schwann cell neoplasms, including schwannomas, neurofibromas, and granular cell tumors, to determine whether two myelin-specific proteins, myelin basic protein and P2 protein, were present in neoplastic Schwann cells" 10/01/1983 - "The immunohistochemical absence of myelin proteins (P2 protein and PO protein) and S-100 protein were against the malignant granular cell myoblastoma and neural neoplasm theory" 08/01/1983 - "Immunohistochemical localization of S-100 protein and peripheral nerve myelin proteins (P2 protein, P0 protein) in granular cell tumors." 08/01/1983 - "The presence and distribution of nervous-system-specific protein (S-100 protein), peripheral nerve myelin proteins (P2 protein and P0 protein) that have not been given any attention in the field of tumor pathology, and striated muscle-related proteins (myoglobin and myosin) were studied in 18 cases of granular cell tumor by the peroxidase-antiperoxidase method" Order ALL the reference details at left...

Therapies and Procedures

1.	Lasers (Laser) 07/01/1979 - "Multiple granular cell tumors of the bronchi: treatment with laser." 08/01/2000 - "Granular cell tumor of the hypopharynx treated by endoscopic CO(2) laser excision: report of two cases." 09/01/2003 - "Four bronchial granular cell tumor patients were treated locally with neodymium/yttrium-aluminum-garnet laser or electrocautery and are in complete remission or have stable residual disease" Order ALL the reference details at left...
2.	Electrocoagulation (Electrocautery) 09/01/2003 - "Four bronchial granular cell tumor patients were treated locally with neodymium/yttrium-aluminum-garnet laser or electrocautery and are in complete remission or have stable residual disease" Order ALL the reference details at left...
3.	Mohs Surgery (Mohs' Micrographic Surgery) 05/01/2007 - "Review of the English language literature revealed four previously reported granular cell tumors treated with Mohs micrographic surgery, none of which was in a child." 05/01/2007 - "We report a granular cell tumor on the distal toe of a 5-year-old child, removed with Mohs surgery" 11/01/2002 - "Mohs micrographic surgery for granular cell tumor using S-100 immunostain." 08/01/2001 - "Granular cell tumor treated with Mohs micrographic surgery: report of a case and review of the literature." 04/01/1985 - "A patient with a large, rapidly growing, spontaneously ulcerating granular-cell tumor was treated by microscopically controlled (Mohs) surgery" Order ALL the reference details at left...
4.	Solid-State Lasers 09/01/1993 - "We report the first case of bronchial obstruction due to granular cell tumor treated with Nd:YAG laser" 09/01/1993 - "Use of Nd:YAG laser in endobronchial granular cell myoblastoma." 03/01/1990 - "Endoscopic Nd:YAG laser treatment of granular cell tumor of the esophagus." Order ALL the reference details at left...
5.	Esophagectomy 09/01/2007 - "Staged closure of tracheogastrocutaneous fistula after esophagectomy for infiltrative granular cell tumor." 01/01/2001 - "This report describes the case of a man who underwent subtotal esophagectomy for the concomitant presence of a multifocal esophageal squamous carcinoma and a granular cell tumor (GCT); he had been previously affected by another metachronous esophageal GCT excised endoscopically" Order ALL the reference details at left...

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